Hi - I'm wondering if anyone here has MTHFR C677T++ and COMT V158M++, and if you're "treating" these mutations successfully with different B vitamins and other things? I've always known I was very bad at detoxing, and now I have proof after getting my 23andme results the other day. I'm also COMT H62H++ and MTRR A66G++. I was going to start off with folinic acid and hydroxo B12, see if they do anything.
My health issues:
I've always struggled with my weight, can't tolerate caffeine or alcohol, have to be careful with diet (I eat low-carb), and have soo much trouble with medications (am not on anything right now). I have depersonalization and have had it 24/7 for the last several years, though for some reason, sometimes I feel a bit better when I'm on my period (when I'm detoxing), like I'll have more energy, feel less anxious, head will be more "clear," and just, my entire body will seem to work better. I'm not sure if it's from dumping estrogen (which would improve thyroid function), and/or from detoxing something else like neurotransmitters (serotonin drops on your period) or heavy metals...could be many things. My depersonalization started when I tried prozac several years ago, and it always felt to me like I had been put on too high of a dose and my body wasn't able to detox the extra serotonin properly, or like it had permanently changed the way my brain metabolizes serotonin. I'm not sure if that makes any sense or not - this is just how it feels.
The only times my depersonalization has completely lifted were 3 times last year while I was going through a (very very long) withdrawal from klonopin: each time I came out of the DP was on the first day of my period - I woke up on that first day and was completely back (world was 3D again, colors were bright, internal monologue had switched back on, could recognize my reflection, had access to the full range of emotions, could "feel" music again, etc). I swear I could feel my entire brain lighting up. The rest of my body was also working better - it seemed like my metabolism had improved, I didn't have cravings for caffeine, my palms were sweaty (made me realize my skin is always super dry), muscles were stronger, etc. Then the next day I woke up and was gone again, or at least I was starting to drift back into the fog (and a day or two later I would be fully "dissociated" again). My DP certainly FEELS like a very physical problem, and seems related to detox - I just don't know how the hell to treat.
Edited by anhedonic56, 05 December 2017 - 09:02 PM.