3 replies to this topic

[stefan_001]

Nicotinamide Riboside Preserves Cardiac Function in a Mouse Model of Dilated Cardiomyopathy.

https://www.ncbi.nlm...2/?i=3&from=nad

 

"Accordingly, we show that NR supplementation in food attenuates the development of HF in mice, more robustly in DCM, and partially after TAC, by stabilizing myocardial NAD+ levels in the failing heart. NR treatment also robustly increases the myocardial levels of three metabolites, nicotinic acid adenine dinucleotide, methyl-NAM and N1-Methyl-4-pyridone-5-carboxamide, which can be used as validation biomarkers for the treatment"

 

 

 

 

[bluemoon]

IRVINE, Calif., Dec. 14, 2017 (GLOBE NEWSWIRE) -- ChromaDex Corp. (NASDAQ:CDXC), a fully integrated, science-based, nutraceutical company devoted to improving the way people age, announced important cardiac research by Dr. Mathias Mericksay and colleagues at the l’Université Paris-Sud, and Dr. Charles Brenner and colleagues at the University of Iowa, published in the journal Circulation.  This research revealed that in a mouse model of heart failure, a loss of NAD levels is accompanied by activation of the nicotinamide riboside (NR) kinase pathway; administration of NIAGEN® in this model stabilizes NAD levels and leads to protective effects on cardiac function that may someday lead to a new therapeutic option for heart failure patients.

 

....In this new research, Drs. Mericksay, Brenner and colleagues discovered that in heart failure, activation of the NR kinase pathway, which occurs as a result of energy stress and NAD depletion is common to humans and mice.  Because of activation of the NR kinase pathway, NR restores but nicotinamide fails to restore NAD levels. Measures of cardiac function are improved with oral administration of NR in this mouse model of heart failure.

 

Because the depression in NAD and the activation of the NR kinase pathway are common between humans and mice, the research strongly suggests that NIAGEN® may be capable of protecting against human heart failure....

 

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I heard Brenner give a talk last December, and he mentioned positive results from a mouse study that showed NR proteced against heart failure and improved heart function in mice with heart failure. I'm not sure if this is the stufy he mentioned or if this is an additional one. Probably the same one he discussed but without quantifying results at the time.   

 

 

https://globenewswir...rt-Failure.html

 

Circulation

http://circ.ahajourn...UzV&keytype=ref

[Mind]

"...in mice, with heart failure". Need to see a similar human study.

[bluemoon]

"...in mice, with heart failure". Need to see a similar human study.

Ye of little faith!

 

I'm optimistic there will be good results in humans since as the article notes  "...the depression in NAD and the activation of the NR kinase pathway are common between humans and mice...." I thought there was a human NR/heart failure trial under way at the U of Washington but can't find any indication that it began.