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Nicotinamide riboside, a form of vitamin B3, protects against excitotoxicity-induced axonal degeneration.

niagen nicotinamide riboside

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#1 stefan_001

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Posted 10 December 2017 - 09:18 PM


https://www.ncbi.nlm...pubmed/28842432

"NAD+ depletion is a common phenomenon in neurodegenerative pathologies. Excitotoxicity occurs in multiple neurologic disorders and NAD+ was shown to prevent neuronal degeneration in this process through mechanisms that remained to be determined. The activity of nicotinamide riboside (NR) in neuroprotective models and the recent description of extracellular conversion of NAD+ to NR prompted us to probe the effects of NAD+ and NR in protection against excitotoxicity. Here, we show that intracortical administration of NR but not NAD+ reduces brain damage induced by NMDA injection"

#2 Mind

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Posted 10 December 2017 - 09:27 PM

In mice? In vitro?



#3 stefan_001

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Posted 10 December 2017 - 09:40 PM

Experiments were done both in vitro and in vivo (mice). More support for NRs potential usefullness against Alzheimer's

#4 able

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Posted 11 December 2017 - 01:42 AM

Haven't read it yet, but I do find this part quite interesting:

 

"intracortical administration of NR but not NAD+ reduces brain damage"

 

Is that because the NR more readily enters cells than NAD+?

 

If so, it could indicate greater effectiveness for NR than NAD+.

 

Or, it could be unrelated to usage of an oral supplement where the NR doesn't reach the same areas in significant quantity to have that effect.

 

It does seem to indicate that in this experiment, increased NAD+ in bloodstream has no impact on NAD+, and no benefit on the brain.

 

Anyone  think something like an osmotic pump to regularly deliver NR direct to the bloodstream might be very effective?

 

 


Edited by able, 11 December 2017 - 02:08 AM.


#5 blind12

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Posted 09 March 2018 - 03:00 PM

I have noticed that I quite suck at intracortical self-administration, unfortunately.


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