12 replies to this topic

[brighty]

Are there any additional benefits to take NMN and NR together? Are these two synergetic? I am already taking 333mg of Niagen everyday in the morning and thinking about adding 25 mg of NMN to my stack in the morning.

 

 

[LawrenceW]

Dr. David Sinclair takes two 500 mg doses of NMN daily.  What exactly do you hope to accomplish by taking 25 mg of NMN?

[brighty]

NMN is very expensive and I cannot afford to take 1 gram of NMN everyday. Right now I have an opportunity to purchase some 25 mg NMN capsules from a reputable vendor for a very good deal. I know 25 mg is a very low dose but this is the most I can afford for now. I am wondering whether I should take advantage of this opportunity and hope that it will offer benefits that are not offered by Niagen.

[Harkijn]

Your original questions did not get any response. That is because we simply don't know the answers.

 

The scant data sofar seems to point to a difference in the speed of absorption in the blood stream and though both NMN and NR lead to higher blood NAD+levels, they may both have other healthful characteristics and in diverging parts of the body. So your hunch about taking them both may not be wrong, though I would not know about any synergy.

If you want to read up on NR vs NMN look here:

http://www.longecity...e-3#entry832423

[aribadabar]

NMN is very expensive and I cannot afford to take 1 gram of NMN everyday. Right now I have an opportunity to purchase some 25 mg NMN capsules from a reputable vendor for a very good deal. I know 25 mg is a very low dose but this is the most I can afford for now. I am wondering whether I should take advantage of this opportunity and hope that it will offer benefits that are not offered by Niagen.

 

I think you should start with the question: How much a 250mg dose ( 10x25mg) would cost you from that vendor?

If that sounds acceptable to you as a daily dose, go for it.

Otherwise, if you plan to do 1 or 2x25mg daily you are wasting your time and money IMO as it is unlikely to get any tangible benefit from such a minuscule dose..

[brighty]

250mg is the normal daily dose for Niagen. I guess the other question is whether NMN is equivalent to Niagen on a mg to mg basis. Does NMN require a lower dose than Niagen in order to produce any effect? On top of that I won't be stop taking Niagen completely even if I go with this. I will taking this minuscule dose in addition to my daily dose of Niagen.

 

Why would several vendors out there even bother to produce 25mg capsule if that dose is not useful? Is that because of marketing reasons?

[brighty]

Nevermind about my last post. I have decided to stick with NR only for now. I am going to be a little more conservative now after reading from another thread that taking too much NAD+ precursors can be bad for us. 

[recon]

Nevermind about my last post. I have decided to stick with NR only for now. I am going to be a little more conservative now after reading from another thread that taking too much NAD+ precursors can be bad for us.

Can you link that post?

[brighty]

Can you link that post?

 

http://www.longecity...-52#entry837734

Edited by brighty, 07 January 2018 - 12:13 PM.

[LawrenceW]

Nevermind about my last post. I have decided to stick with NR only for now. I am going to be a little more conservative now after reading from another thread that taking too much NAD+ precursors can be bad for us. 

 

 

Stefan001 theorized that my taking 7,500 mg per day of NMN was too much.

[osris]

Nevermind about my last post. I have decided to stick with NR only for now. I am going to be a little more conservative now after reading from another thread that taking too much NAD+ precursors can be bad for us. 

 

There is a post on the other thread that says this sort of caution has no scientific basis:

 

https://www.longecit...-52#entry837770

 

Brighty wrote:

 

 

Well what we unfortunately know is that ultra high NMN dosing does not trigger any long lasting health benefits. On the contrary there seems to be a risk for accelerated aging after stopping - according your experience the detoriation rate is 34 years / calender year

 

 

Turnbuckle replied:

 

"This is an interesting comment, though I wish stefan had included research to back it up. In any case, taking anything that ups NAD continuously for a long period of time is likely a bad idea. Mitochondria make their own NAD, and if you supply all they need, then mtDNA loops that are defective for producing NAD can build up as they are shielded from quality control. Cells thus become addicted to the exogenous supplement. Take it away and don't be surprised if those cells go into a rapid decline as mito function drops off a cliff."

 

Edited by osris, 25 January 2020 - 07:33 PM.

[SomethingClever]

NMN is very expensive and I cannot afford to take 1 gram of NMN everyday. Right now I have an opportunity to purchase some 25 mg NMN capsules from a reputable vendor for a very good deal. I know 25 mg is a very low dose but this is the most I can afford for now. I am wondering whether I should take advantage of this opportunity and hope that it will offer benefits that are not offered by Niagen.

Can you share your source for the NMN? What is the price?

[SearchHorizon]

I don't know if this has been discussed but NMN's bioavailability is an issue. NMN is probably cleaved at the gut, and NAM is absorbed instead.  Chris Masterjohn mentioned this in Peter Attia's podcast.