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How to decrease Excitatory Amino Acid Transporter 2 (EAAT2 aka GLT-1 & SLC1A2)?

eaat2 slc1a2 glt-1

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#1 dk2011

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Posted 07 January 2018 - 12:40 AM

Glutamate transporter


Glutamate transporters are a family of neurotransmitter transporter proteins that move glutamate – the principal excitatory neurotransmitter – across a membrane. The family of glutamate transporters is composed of two primary subclasses: the excitatory amino acid transporter (EAAT) family and vesicular glutamate transporter (VGLUT) family. In the brain, EAATs remove glutamate from the synaptic cleft and extrasynaptic sites via glutamate reuptake into glial cells and neurons, while VGLUTs move glutamate from the cell cytoplasm into synaptic vesicles.



Delayed post-ischemic administration of CDP-choline increases EAAT2 association to lipid rafts and affords neuroprotection in experimental stroke


Glutamate transport is the only mechanism for maintaining extracellular glutamate concentrations below excitotoxic levels. Among glutamate transporters, EAAT2 is responsible for up to 90% of all glutamate transport and has been reported to be associated to lipid rafts. In this context, we have recently shown that CDP-choline induces EAAT2 translocation to the membrane. Since CDP-choline preserves membrane stability by recovering levels of sphingomyelin, a glycosphingolipid present in lipid rafts, we have decided to investigate whether CDP-choline increases association of EAAT2 transporter to lipid rafts.


...In summary, we have demonstrated that CDP-choline redistributes EAAT2 to lipid raft microdomains and improves glutamate uptake...






How would one go about LOWERING EAAT2 or decreasing it's association of EAAT2 transporter to lipid rafts?

#2 Believer

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Posted 07 January 2018 - 10:35 PM

Several things decrease glutamate transport (uptake) like creatine (which is quite effective, by the way) but be careful as lowering glutamate is a good way to induce cognitive dysfunction and psychosis.

A ketogenic diet definitely also lowers glutamate levels.


As for neuroprotection, the niacins (nicotinic acid and niacinamide) are effective.

Edited by Believer, 07 January 2018 - 10:35 PM.

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#3 monowav

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Posted 24 February 2018 - 12:43 AM

I wrote about this last year https://mybiohack.co...porter-activity

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