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Alzheimer drug turns back aging


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#1 beijair

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Posted 10 January 2018 - 01:58 AM

I've been out of town and not able to post much but noticed the below in science news and wanted to share and get see if anyone k iws more about it.

Alzheimer’s drug turns back clock in powerhouse of cell
Researchers identify molecular target of J147, which is nearing clinical trials to treat Alzheimer’s disease
January 9, 2018
Salk Institute for Biological Studies
The experimental drug J147 is something of a modern elixir of life; it's been shown to treat Alzheimer's disease and reverse aging in mice and is almost ready for clinical trials in humans. Now scientists have solved the puzzle of what, exactly, J147 does. They report that the drug binds to a protein found in mitochondria, the energy-generating powerhouses of cells. In turn, they showed, it makes aging cells, mice and flies appear more youthful.

#2 Turnbuckle

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Posted 10 January 2018 - 12:30 PM

Very unlikely. This drug works by jazzing up mitochondria and that can be an advantage short term, but will not give you much in the long run as it does nothing to enhance quality control. And though the researchers studied it in mice, they didn't share any longevity data, and they found no advantage in the chemistry of brain aging--


We performed targeted metabolomics on brain and plasma extracts from 3- and 10-month-old
SAMP8 control or J147-treated mice (Currais et al., 2015). No significant differences in the drift of the brain metabolome were observed
between old and young animals. 



They only reported life extension for flies, but it wasn't much--
Due to its effect on AMPK/mTOR signaling and suppression of
transcriptional/metabolic drift, we then asked whether J147 could
extend lifespan using Drosophila. In these experiments, 100 nM and
2 mM J147 administered in the food starting at 1 week of age
increased longevity, extending median lifespan by 9.5% and 12.8%,



Beyond that, there is a conflict of interest with one of the researchers--a patent application--so you can expect some inflated statements about it.

Edited by Turnbuckle, 10 January 2018 - 12:41 PM.

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