6 replies to this topic

[nooguyz]

I have seen some topics about people who take Mucuna Pruriens... And they say that it is followed by a low/causes dopamine downregulation?

 

I am wondering if that's true, because in the end I am looking for a way to increase my dopamine constantly, not just for an hour or two, and not to increase it for a day and then feel sluggish the next day even if I take it.

 

I have not tried this herb, but I do not want to spend money on something that doesn't work the way I want it to work.

 

So please comment and let me know your experiences with this herb? And perhaps some suggestions on other herbs that would increase my dopamine, since I have been low on dopamine for over a decade now, except for an occassional random high that lasts for like 20 or 30 hours when I get really excited about something...

 

Thanks! 

[Galaxyshock]

At some point the good effects start fading and I only experience side effects. It is the most powerful herb to increase dopamine but seems to only be good for short courses 3-4 weeks or so.

 

In your situation I would probably take Cordyceps - increases dopamine biosynthesis and steroidogenesis, inhibits MAOB.

[Nate-2004]

EGCG is a better inhibitor of MAO-B, but take it on an empty stomach. It is water soluble. Protein interferes with absorption. People with less COMT tend to absorb EGCG better and EGCG may also inhibit COMT.

 

With less MAO-B and less COMT you're going to have more dopamine.

 

Also as I've stated elsewhere on the board: Lithium Orotate (5mg) daily or every other day can help induce the tyrosine hydroxylase enzyme that converts tyrosine to L-Dopa using vitamin B6 as a substrate. You can use these to optimise the situation.

 

Also Rhodiola is an MAO-B inhibitor but I'd not use it often as it may also inhibit MAO-A.

 

I also found this guide helpful.

Edited by Nate-2004, 12 February 2018 - 03:30 PM.

[nooguyz]

At some point the good effects start fading and I only experience side effects. It is the most powerful herb to increase dopamine but seems to only be good for short courses 3-4 weeks or so.

 

In your situation I would probably take Cordyceps - increases dopamine biosynthesis and steroidogenesis, inhibits MAOB.

Thanks for the tip! I have found some 40% Extract Powder 20:1, how much of that would I have to take daily?

 

And when Mucuna wears off, how long do the side-effects last, and how soon can you start taking it again? 3-4 weeks isn't as bad as I thought, I think...

 

EGCG is a better inhibitor of MAO-B, but take it on an empty stomach. It is water soluble. Protein interferes with absorption. People with less COMT tend to absorb EGCG better and EGCG may also inhibit COMT.

 

With less MAO-B and less COMT you're going to have more dopamine.

 

Also as I've stated elsewhere on the board: Lithium Orotate (5mg) daily or every other day can help induce the tyrosine hydroxylase enzyme that converts tyrosine to L-Dopa using vitamin B6 as a substrate. You can use these to optimise the situation.

 

Also Rhodiola is an MAO-B inhibitor but I'd not use it often as it may also inhibit MAO-A.

 

I also found this guide helpful.

I have looked into EGCG and found some Green Tea Extract Powder 90% Polyphenols 50% - how much of that am I looking to take daily? As I understand the effects would be general and wouldn't be "time-dependent" for this one, they build up like Bacopa?

As for Rhodiola, I was planning to take it daily actually, for memory and congition improvements, but I am still considering various supplements and I have to focus on more important things. What's the point in better memory if I don't have motivation to get up in the morning and sleep for ten or twelve hours on my worse days? :-)

 

Lithium - I actually looked into it before, but I cannot find one without a bunch of additives (silica, magnesium stereate, that kind crap)... :/ B6 I am already supplementing though. 

[Nate-2004]

With EGCG I don't think there's any kind of build up.

 

This is the lithium I got, 120mg orotate with 5mg elemental lithium.

 

https://www.amazon.c...ge?ie=UTF8&th=1

Edited by Nate-2004, 13 February 2018 - 03:19 AM.

[nooguyz]

With EGCG I don't think there's any kind of build up.

 

This is the lithium I got, 120mg orotate with 5mg elemental lithium.

 

https://www.amazon.c...ge?ie=UTF8&th=1

Hmm, but how should EGCG be taken then, and in what form (I'm mostly interested in the timeframe here) will I feel the results?

 

Thank you for the link. :-)

[nooguyz]

EGCG is a better inhibitor of MAO-B, but take it on an empty stomach. It is water soluble. Protein interferes with absorption. People with less COMT tend to absorb EGCG better and EGCG may also inhibit COMT.

 

With less MAO-B and less COMT you're going to have more dopamine.

 

Also as I've stated elsewhere on the board: Lithium Orotate (5mg) daily or every other day can help induce the tyrosine hydroxylase enzyme that converts tyrosine to L-Dopa using vitamin B6 as a substrate. You can use these to optimise the situation.

 

Also Rhodiola is an MAO-B inhibitor but I'd not use it often as it may also inhibit MAO-A.

 

I also found this guide helpful.

I just read up more on the thing and I was wondering - why is it bad that it also inhibits MAO-A? From the info I found, both MAO-A and MAO-B breaks down dopamine and other neurotransmitters (if I'm wording this correctly, please correct me if I'm not).

 

I'm just trying to understand the whole thing here.