Sartans - perhaps the most powerful geroprotector
sartans:
- prevent and treat type 2 diabetes mellitus;
- reduce pressure;
- protect the kidneys and liver;
- suppression of glycation of proteins;
- protect the muscles from aging;
- increase endurance during work;
- inhibit the development of atherosclerosis;
- protect the brain from aging, stroke and Alzheimer's disease;
- protect bones from osteoporosis;
- protect from stress;
- prevent many cancers;
- improve the sexual function of men;
- slow the development of prostatic adenoma and uterine fibroids;
- suppress inflammation;
- prolong the maximum life expectancy of hypertensive rats by half (!) and, possibly (what you need to prove) and wild healthy mice to 26% (after all, genetically modified mice with detached AT1 receptor lived 26% longer);
- significantly reduce the mortality from all causes in people with high blood pressure.
Graph of the mortality curve of rats suffering from hypertension. The graph shows that such rats receiving treatment with Sartans live twice as long.
Note that classical drugs for prolonging life, such as metformin, etc., reach 36% of the maximum life span of mice genetically predisposed to various diseases, and healthy mice of wild mice - no more than 5% (more women).
And the genetic blockade of the angiotensin II receptor (AT1a receptors), as shown in the graph below, allows such transgenic mice to live 26% more (and the maximum and average lifespan grows by 26%) than wild "healthy" mice. It's very, very strong.
Scientist Alexander Fedintsev (coordinator of research at the Scientific Research Institute of Antimicrobial Chemotherapy) is actively studying the Sartans and their impact on life expectancy:
source: http://nestarenie.ru...protektor.html (Full article in Russian)
Outstanding results were obtained with the use of Telmisartan: https://en.wikipedia...ki/Telmisartan
Telmisartan from all Sartans is the most lipophilic and therefore best penetrates deep into the tissue, providing both local (tissue) and systemic blockade of angiotensin II receptors (AT1 receptors). Telmisartan has the longest half-life among the Sartans - more than 20 hours. This provides reliable and round-the-clock blocking (AT1 receptors).
Edited by Kentavr, 17 February 2018 - 09:24 PM.