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Chris Linnell's Longevity Review Newsletter



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March 2024 Longevity Review

Posted by Chris Pollyanna , 14 April 2024 - - - - - - · 123 views
supplements, young blood and 6 more...
March 2024 Longevity Review As winter enters the rearview mirror, March’s highlights included three lifespan extending studies involving young blood plasma, a two drug synergistic combo and the main bioactive molecule found in mushrooms, and the Canadian content section returns with a groundbreaking study leveraging the powers of AI for drug development.  In addition to the...



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February 2024 Longevity Review

Posted by Chris Pollyanna , 24 March 2024 - - - - - - · 192 views
supplements, rapamycin, fasting and 6 more...
February 2024 Longevity Review As we get past the heart of winter, this month we will take a look at how partial reprogramming extends the remaining lifespan of old naturally aged mice; how the Fasting Mimicking Diet reduces biological age; a comparison of intermittent versus continuous dosing of rapamycin in mice; and, a human senolytic trial which raises some concerning questions....



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January 2024 Longevity Review

Posted by Chris Pollyanna , 27 February 2024 - - - - - - · 351 views
supplements, longevity, senolytic and 4 more...
January 2024 Longevity Review Kicking off the new year with a bevy of interesting longevity research including the intriguing possibility of lifelong protection against senescent cells, harnessing the immune system’s pathogen response to treat ageing, using rapamycin to encourage hair growth, and, in a new addition focusing on Canadian researchers working on longevity, a novel compoun...



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November 2023 Longevity Review

Posted by Chris Pollyanna , 26 February 2024 - - - - - - · 171 views
supplements, longevity, rapamycin and 4 more...
November 2023 Longevity Review This review was a few sentences and an intro away from being finished a few weeks ago before the drama of needing to get a last minute passport derailed my ambitions. I also then used the festive period visiting family in Germany to do a social media/digital/longevity detox for the first time in a number of years. Mea culpa aside, this month’s review is b...



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December 2023 Longevity Review

Posted by Chris Pollyanna , 30 January 2024 - - - - - - · 342 views
longevity, supplements, exercise and 4 more...
December 2023 Longevity Review As we wrapped up the year and took a well deserved holiday break, the longevity studies kept on coming. This month we will take a look at the latest results from the ITP, the gold standard of longevity studies; how CD38 is a prime culprit for ovarian ageing and lung fibrosis, and how it can be counteracted; how high consumption of fruits and vegetables in...



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October 2023 Longevity Review

Posted by Chris Pollyanna , 25 November 2023 - - - - - - · 1,183 views
supplements, nad+, nmn, fasting and 4 more...
October 2023 Longevity Review Hello and welcome again to this month’s longevity review. The big news this month is that exosomes (small packets of chemical information cells use to communicate with each other) from young pig plasma were able to cross the species barrier and rejuvenate certain biomarkers in old rats. In addition, a small molecule was found to help repair older tendon i...



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September 2023 Longevity Review

Posted by Chris Pollyanna , 01 November 2023 - - - - - - · 558 views
supplements, lifestyle, nad+, nmn and 5 more...
September 2023 Longevity Review Welcome to another Longevity Review. The highlights this month include gene therapy for memory enhancement, exosomes for osteoarthritis, senolytics to regenerate the small intestine, NMN for blood pressure, and how it is never too late to start exercising.
In the supplemental section, there was another human trial result for senolytics, this time in A...



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August 2023 Longevity Review

Posted by Chris Pollyanna , 26 September 2023 - - - - - - · 1,356 views
supplements, nmn, nad+, fasting and 2 more...
August 2023 Longevity Review The dog days of summer might not have been conducive for productivity, but that didn’t stop plenty of longevity studies being published. A trio of papers showcased the potential of a platelet factor to mimic the benefits of exercise, while combining Metformin & Galantamine might be the solution for muscle wasting. A universal ageing clock for mammals...



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July 2023 Longevity Review

Posted by Chris Pollyanna , 17 August 2023 - - - - - - · 824 views
supplements, longevity, nad+, nmn and 4 more...
As you hopefully relax and idle away the sultry summer season, the publishing of longevity studies continues unabated. July saw the first use of the longevity factor klotho in older primates, and the first time lifespan extension has been shown in heterochronic parabiosis (the co-joining of young & old mice), not to mention similar lifespan extension...



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June 2023 Longevity Review

Posted by Chris Pollyanna , 10 July 2023 - - - - - - · 785 views
supplements, lifestyle, fasting and 6 more...
As we round off the first half of the year, the big story from June was that taurine was shown to potentially boost both lifespan in mice and healthspan in monkeys. In addition, there was more progress in translating senolytics to humans with a long term monkey study, as well as using AI to discover additional senolytic molecules. To get an idea why senol...



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