Hello,
i am not a doctor and i have a very nooby question.
I know that David Sinclair takes both NMN and also Metformin. Now i stumbled across this paper
https://www.ncbi.nlm...les/PMC5102768/
where it says:
"We find that complex I supports proliferation by regenerating NAD+, and metformin’s anti-proliferative effect is due to loss of NAD+/NADH homeostasis and inhibition of aspartate biosynthesis. "
Does this indicate that the positive effects of Metformin are because less Nad+ is created in the cells?
Could any biochemist give me some advice here? Thanks a lot!