Atleast in part they seem to be critical from the recycling of methionine into SAM-E (methionine adenosyltransferase)?
Pretty much every ATP molecule is magnesium dependent and sulpher donors such as taurine could theoretically profide the body with plenty of a sulfur reservoir to link methionine to adenosine to form SAM-E.
Also this raises another question, when one supplements with exogenous SAM-E, what would happen with methionine adenosyltransferase. Surely the body is incredibly good at maintaing homeostasis.
When you consider that alterations in sam-e/sah/homocysteine/methionine ratios are associated with psychosis and mania. On top of that exogenous SAM-E seems to do an incredibly good job of inducing these symptoms in a large amount of the population. Now methionine alters the kynurenine pathway and therefor could alter ratios between quinolinic acid/kynurenic acid. Now it doesnt end there, since SAM-E is also critical cofactor for spermidine and spermine synthesis you can imagine what drastic changes this could have upon the body.
Thoughts on this?
Edited by MankindRising, 04 January 2019 - 09:53 PM.