hello let me give you some of my background. I have suffered from social anxiety whole my life and it wasn't until I was around the age of 18 I started researching and looking into why and perhaps drugs that could help me. Anyway it took me a long time to figure things out because I started with zero experience and knowledge, on top of that im not the brightest guy im kinda slow but I have very good reasons for that which I won't get into. Anyway on my journey was I was experimenting with drugs and supplements I just bought whatever without even looking into the science and wasted a lot of money. it was not until I was around age of 19 that I looked into biology and stuff and, anyway to make a long story short I realize my anxiety is caused by excess CRHR1. To make the story even shorter I have found a drug or two that might help (valproic acid, lithium carbonate) in high dosages as they decrease this protein CRHR1 in the brain. but the thing is, when I take any drug or supplements they have zero effect on me, they just pass trough like I took nothing. For example rhodiola rosea used to have an stimulating effect on me, not anymore. Memantine effect was very strong and obvious but now nothing. Im not sure what the cause is but I can tell you, the CRHR1 excess has caused a tremendous stress and anxiety on my mind/body and my health has suffered very much, I have fatigue that you cannot imagine and I dont think many people would survive being in the same place i am. Anyhow(I love this word), what do you guys think could be the cause for this? it's not a tolerance thing because I dont abuse them and i have tried new drugs that i never taken before and yet no effect for example tianeptine should have an obvious effect im certain. My question is simple, given what I have told you so far, stress > health downgrade > fatigue > drugs not working, what could you make of this do any information so far, does it hold any merit? I just want drugs and supplements to work again so I can fix my social anxiety with the two latter drugs i've mentioned. No route of administration have an effect on me and I have tried many (topical,orally,sublingual,rectum,snorting). What I have not tried is injecting which is what I will do if nothing else works or if you guys have no advice for me. But first I wanna heal my body using Ubiquinol (Active COQ10) becuase im taking it orally and it has no effect so I will find a way to inject it directly into my bloodstream. I have ordered some probiotics and l-glutamine because they apparantly help with the GI tract were drugs are absorbed orally but then again wouldn't this be pointless because other ROA have not worked for me which bypass the gastrointestinal tract. https://www.ncbi.nlm...les/PMC3914806/ this study says probiotics when taken with a drug increased the drug by 43%.
Other possibly causes:
-Inflammation
-Low mithochondria (your body needs energy to transport the drugs)
- free radicals (bad bacteria kills the drug before it can have an effect) OR the good bacteria are too busy fighting bad bacteria to use the drug
- Low pottasium or sodium? (energy for ATP)
-
here is a good video maybe give you guys some idea:
more info on my other threads:
https://www.reddit.c...on_with_severe/
https://www.reddit.c...ase_absorption/
https://www.reddit.c...lammatory_drug/
Edited by farshad, 05 May 2019 - 02:38 PM.