Apparently there have been some adverse reactions to some FAAH inhibitors (up to and including brain death).
FAAH inhibitors in the limelight, but regrettably
n January 2016, we were informed of the exceptional occurrence of serious adverse events (SAEs) in a phase I clinical trial conducted by the Biotrial Pharmacology Center (Rennes, France) on behalf of Bial-Portela & Ca. SA (São Mamede do Coronado, Portugal). The trial involved the compound BIA 10-2474, a drug designed to inhibit fatty acid amide hydrolase (FAAH). After two initial phases (single escalating doses up to 100 mg, and kinetics-food interaction studies) without any untoward SAE, the phase in question, which intended to examine the effect of multiple doses (5 or 6 daily doses), resulted in SAEs in 6 participants, who had all been administered the highest tested dose (50 mg). This was a threshold effect, since no SAE had been reported with the lower dose of 20 mg given to the volunteers previously. The most serious symptoms had central neurological features, the worst being those associated with a single case of coma which rapidly lead to brain death. Of the other 5 hospitalized participants, 2 had serious neurological damage (with clinical improvement apparently occurring within a few days). Because of these events, the trial was immediately suspended.
Edited by Daniel Cooper, 24 October 2019 - 08:37 PM.