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Depression - no solid cure?

depression shizsucks anhedonia ssri/snri/maoi/tryciclic/atypical

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#1 vader

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Posted 22 May 2020 - 06:33 PM


I think that medicating depression is futile. I have tried now many numerous anti-deps - they all suck for protracted depression / dysthymia / ptsd / anhedonia, whatever You want to call it. If it's sickness behavior, then we should treat the sickness - but how (then again, many people even on their death-bed seem to be perfectly fine hedonists with no evident depression)? Even new treatments like ketamine or psilocybin give short-lived results at best. 



#2 experimenting

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Posted 23 May 2020 - 12:28 AM

Man, I’ve dealt with depression like symptoms for years. You’ll see my post history, I have been fighting the fog forever. I’m still not getting anywhere yet, and I’m considering giving up the fight.

But you shouldn’t give up yet. Have you done all bloodwork? Literally everything? Tried every vitamin, amino acid to start with? Dietary modifications? Hormone modifications?

Antidepressants were useless for me too-because I have so many physical symptoms, my problem isn’t solved by adjusting my neurotransmitter ratios.

But that doesn’t mean there isn’t a cure for you. You just have to get creative. Carefully list your mental AND physical symptoms. Labwork. Etc etc.

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#3 experimenting

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Posted 23 May 2020 - 12:30 AM

I think that medicating depression is futile. I have tried now many numerous anti-deps - they all suck for protracted depression / dysthymia / ptsd / anhedonia, whatever You want to call it. If it's sickness behavior, then we should treat the sickness - but how (then again, many people even on their death-bed seem to be perfectly fine hedonists with no evident depression)? Even new treatments like ketamine or psilocybin give short-lived results at best.


Look at your family members too. What symptoms do you share with them?

#4 gamesguru

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Posted 23 May 2020 - 01:08 PM

A lot of treatment resistant depression has anhedonic traits, and a probable dopamine or glutamate component.

 

It's a matter of finding something that works for you.  For me it's tea, magnesium, turmeric.  Commercial antidepressants don't directly work by serotonin, it's a lever mechanism which controls BDNF and hippocampal neurogenesis with some secondary rewiring down the serotonin pathways.  This effect, and the bulk of the benefits, can be obtained by myriads of other approaches.  Exercise and flaxseed with a more balanced diet would have significant benefits alone.



#5 experimenting

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Posted 23 May 2020 - 06:31 PM

A lot of treatment resistant depression has anhedonic traits, and a probable dopamine or glutamate component.

It's a matter of finding something that works for you. For me it's tea, magnesium, turmeric. Commercial antidepressants don't directly work by serotonin, it's a lever mechanism which controls BDNF and hippocampal neurogenesis with some secondary rewiring down the serotonin pathways. This effect, and the bulk of the benefits, can be obtained by myriads of other approaches. Exercise and flaxseed with a more balanced diet would have significant benefits alone.


Hey mate-

Did you manage to look at my thread in Brain Health?

Have I gone completely insane?

#6 Rorororo

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Posted 23 May 2020 - 11:43 PM

Depression is hard because it is such a generic disease.  It just means something is depressed.  You can treat it if you eliminate any possibilities, this will take time and money.  You can also use process of elimination (a good pysch. should be able to do this) by using attributes of your lifestyle, personality to pinpoint on what exactly is low. 

 

Its like asking is there a treatment for people that are high.  It depends, what exactly is high? Which level is high?

 

Don't keep your hopes down, there is MANY ways to treat some one now a days!



#7 jack black

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Posted 09 June 2020 - 02:58 PM

i had dysthymia all my life and some other comorbid conditions too. the only antidepressant that worked for me was Serzone, but it was pulled from the market many years ago due to ridiculously rare liver complications. it worked so well, i took 1/8 of pill every day with clear benefits and no side effects.

 

over the years, i figured out these were things that helped me to lessen my condition a little bit: vit B complex, NAC, Ashwaganda, carnosine, and lithium orotate. occasional psychodelics work too. i tried tons of other things with no results.

 

eating vegetable based diet (especially beans) helps me, but gluten and simple carbs make it worse. alcohol makes it worse.

 

the biggest help was actually from reading books on CBT, practicing mindfulness, and changing my outlook on life and my mindset. i used to be a perfectionist pessimist asshole and it was killing me slowly. now i forced myself to see glass half full, be spiritual, and engaged with friends and family, and developing strong and meaningful human connections.

 

IMHO, medications are useful to jump start your transformation, but one will not get better long term without hard work on your psychological issues. i'm sure good therapists can help with that, but i was not fortunate to find a good one. it can be done by yourself. the info is free and available on the internet/youtube, etc. 



#8 gamesguru

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Posted 09 June 2020 - 08:21 PM

there are some new breakthroughs on anhedonic depression.  Sometimes lifestyle choices like exercise, diet and attitude, and little things like turmeric/ginger, flaxseed, and magnesium can give a good boost.



#9 poonja

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Posted 09 June 2020 - 08:53 PM

Please check the first post regarding j142.  He reports long standing del depression that was cured four days after be inning use of j147.  I do nor suffer from depression but have found a mind brightening effect.  No known side effects.  well worn checking out imho.



#10 gamesguru

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Posted 09 June 2020 - 09:59 PM

its fake, he never had depression.  And you can't claim remission after 4 days.  Need months follow-up to confirm result.



#11 joee

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Posted 10 June 2021 - 05:51 PM

Turns out depression isnt really a thing.  Let me explain.  Sad feels, 'depressed' feels- are supposed to be temporary, passing things.

Ive been diagnosed with dysthimia at first.  Long lasting moderate to mild depression with bouts of legit heavy depression mixed in.

What Ive learned from a LIFETIME of wrestling with this.

Im not depressed.  I can be... but my issue..   Im BORDERLINE.  I have borderline personality disorder.  And I DISSOCIATE or had a habit of doing it.

I believe depression not to be an actual feeling, but a place along a spectrum between complete dissociation, and vitality.  With depression being close to dissociation.  
I see it as a retreat, a semi constant FREEZE response.

At least this is the picture I have of myself, for this issue.  Because long term depression, aint really a thing.  Feelings are transient.



#12 Dustin Bernhard

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Posted 11 June 2021 - 10:48 PM

I like the new approach they're taking with psilocybin and other previously illegal drugs. I do believe their are a lot of benefits to be had from the psychedelic experience. The problem comes when you reach the integration step as it's often a very spiritual or even religious experience but since most people already have there pre-conceived ideas about spirituality and religion it can be difficult to experience the full benefits. Even with an open mind some people just can't really wrap their heads around spirituality and all the lessons plant teachers have to offer us as they are kind of like solving riddles in a way and can also be quite complex, well psychology in general is complex as well though I guess. Often they'll learn about the neccessary lifestyle changes they need to make. Usually the same things a doctor would tell you but for some even a mystical experience like that isn't enough to really drive the point home unfortunately.
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#13 EvaWhite

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Posted 11 July 2021 - 04:52 PM

Spirituality is one way. I was doing meditation to get out of thing when I had that phase. 







Also tagged with one or more of these keywords: depression, shizsucks, anhedonia, ssri/snri/maoi/tryciclic/atypical

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