It's been quite a while since I've looked into R. Back then (10+ years ago? perhaps on this forum or the one it was spawned from) it was generally agreed that taking R in the morning on an empty stomach was the best way to take it. The belief was that you wanted a high and quick spike to activate genes and it didn't really matter how long it stayed in your system once the spike was achieved ... as opposed to taking it with food which would slowly release it into the bloodstream over a longer time. The goal of course being life extension.
1) Is this still the case? I recently saw an interview with Dr. Sinclair and he said he takes it with yogurt (ie- not on an empty stomach) in the morning. I've also read others saying it's better absorbed with food, take it before you sleep since it synergizes with melatonin, etc etc. Got me wondering if taking it in the morning on an empty stomach was still regarded as the best way?
2) What are your thoughts on taking R with piperine? I've read that it increases absorption and also reduces the amount of R metabolite seen in the blood (which was said as a good thing) ... but the thing is, I always thought R's metabolite was also good and exerted a positive effect?
I'm pretty out of the loop on R as the last I seriously looked into it was like 10+ years ago back when it had big hype behind it. Thanks for any advice.