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Andy Milonakis Is 33 but looks 14


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#61 TheFountain

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Posted 04 April 2009 - 11:40 PM

This guy has the haircut and clothing of a teenager.

Dude, give me a break. What is the 'haircut and clothing of a teenager'? Plain t-shirt? letting the hair grow a little longer than a centimeter? That's just ridiculous. First it's his body fat making him look like an adolescent, then it's his 'haircut and clothing'. You guys just totally transcend the word denial. We need a new term for you. Because no one who has not previously known his age and then seen him in real life, video, or photo, has thought he was a day older than 15-16 MAX! I am 100% convinced you folks are making things up in your heads to suit some predesigned agenda or some kind.

Here is a video filmed by him 2 weeks ago. If you view many of the negative video comments he obtains from viewers you will note that all of them think he is a wise ass adolescent, hence their misunderstanding and, in some cases, hate toward him.


Edited by TheFountain, 04 April 2009 - 11:44 PM.


#62 Brafarality

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Posted 05 April 2009 - 01:22 AM

The 8 megapixel paparazzi pics of this guy on this thread are misleading and suggest that he looks wizened or like a fat old hag in person, albeit with adolescent fat distribution. In order to better compare him to typical pics posted on this forum, a screen capture from one of the YouTube clips is a better representation:

Posted Image

He could have easily played the raunchy kid in Superbad.
Like it or not, this guy's good.

Edited by paulthekind, 05 April 2009 - 01:22 AM.


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#63 spacetime

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Posted 05 April 2009 - 02:16 AM

Is this phenomena mostly isolated to males? I don't ever recall seeing any females with this condition. Then again I've only seen several males with this condition, Andy, Gary Coleman, Emmanuel Lewis. All of them are quite short which might indicate a GH deficiency. Perhaps they are also afflicted with a 5ar enzyme inhibition or deletion so they don't exhibit secondary sex characteristics. There are a couple people here who look nearly half their age because of lack of facial hair. Perhaps if they had a GH deficiency they too would look 13.


soft skin, low muscle tone, short stature, higher voice. All of these aesthetic definitions of youth can be explained by his condition. Low production of sex hormones can cause a feminine, softer, appearance and higher voice (see eunuch singers such as Alessandro Moreschi, who was castrated before puberty). Testosterone causes a change in texture to skin. Note, low sex hormones do not correlate directly to infertility.

hmm, then why is it that scientists are using sex hormone treatment to treat infertility? Hormones, such as kisspeptin are being used to balance hormone levels in infertile people. That shows there is obviously a correlation between sex hormone and sexuality. And the anecdotal fact that andy has had 5 children with several women pretty much cancels out your presumption on this ground.


That shows there's a correlation between sex hormone and sexuality, in what manner? How are we defining the latter term. The anecdotal fact that he has several kids does not negate the fact that one could have low sex hormones and not be infertile. I've seen 11-12 year old boys who are fathers and they have all the appearances of low sex hormones, yet admitttedly, without bloodwork we won't really know.

#64 Skötkonung

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Posted 06 April 2009 - 02:26 AM

has it really been 'identified' as this, or has it been dismissed as this?

Andy has self identified his condition as a congenital growth hormone disorder. Do some research before making assumptions:
His youthful appearance is neither an act nor a miracle of makeup. It'sthe result of a "growth hormone problem," as he told the New YorkObserver a couple years ago, when "Super Bowl" went national.

No, to identify him as young looking we need only look at him.

Forgive me, I misspoke. \What I meant to say was "To identify Andy as being truly young we need to first define which of his characteristics we are associating with youth." Correlation is not always causation. One can look old without being old or look young without being young. By dissecting which of Andy's physical qualities we are specifically attributing to "his youth," we can determine if the various symptoms of his disorder are actually causing him to be young or just have side effects that can be mistaken as youth (such as texture of skin, stature, voice, etc).

hmm, then why is it that scientists are using sex hormone treatment to treat infertility? Hormones, such as kisspeptin are being used to balance hormone levels in infertile people. That shows there is obviously a correlation between sex hormone and sexuality. And the anecdotal fact that andy has had 5 children with several women pretty much cancels out your presumption on this ground.

The circumstances that cause infertility likely vary from person to person. To say that all individuals that have low sex hormones are incapable of reproducing is a gross generalization. If you bothered to read any of my previous post you would have seen my above source discussing that causation of gh deficiency and sex hormones. You would have also seen that many people afflicted with gh deficiency go on to have children (such as Charles Sherwood Stratton also referenced above).

Unless we equate aging with a bio-linear phenomenon, as most people tend to do. It could be that systemic metabolic failure due to protein farnesyltransferase contributes to the 'appearance' of aging in these people. Or it could be that there are other, as yet unknown variables we have yet to observe. Either way, something is leading to the 'effects' of aging in these children. Despite whether or not they are aging in the bio-linear sense we often describe. And it is distinctly separate from Andy Milonakis condition.

Progeria is not considered a model of human aging because not all organs are affected. There is, for example, no evidence of senility or of aging in the central nervous system. I was using progeria as an example of a condition that causes visible signs of aging but is not actually considered by the contemporary medical community as being related to aging itself. In this respect, it is similar to Andy's condition in that both conditions cause what appears to be the slowing (hastening) of aging, even though they are doing no such thing.

Your point of this was to somehow show that if we 'look deeper' we can actually see a 33 year old man under there somewhere. Hence..

And andy still looks like a 14 year old kid. But the disillusionment continues below with...

Yea, he might actually look a whole 16 years of age then! Wow!

Wow, a lot of attitude in this response. It is almost hard for me to dissect your arguments from the thick condescending attitude. For someone who is making such an extraordinary claim and is clearly carrying the burden of proof, I have seen you bring no evidence to this discussion to support your claims. On the contrary, you have failed even to do even basic research on Andy's condition -- having admittedly stated that you were unsure if he had officially commented on actually having a congenital growth hormone deficiency (Google quickly provided an answer here).

#65 alexd

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Posted 07 April 2009 - 11:43 PM

I live to be misunderstood. The point I was making about the photo was simply context. I knew a woman who was fairly ordinay looking most of the time but when she dressed to kill she was stunning. Same person but my perception had been changed by the different input. I was stating that his hair cut and t shirt caused me to be biased! The second point of where is the science is based on the idea that we need something we can rely on that is out side of simple visual information.

If he is younger than his years I want proof or at least an opinion of someone who is qualified to make the call, so that the why aspect can be looked into. I certainly am not that person.

#66 Ben Simon

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Posted 08 April 2009 - 12:23 AM

Now, I feel to post some information to make things clear here. There seems to be a lot of misconceptions.

If you suffer from deficiencies in hormones in the pituitary gland(hypopituitarism) and do not go through puberty, yes you will look boyish and young,but you will not become healthier and get an extended lifespan.

So let's for the umpteenth time conclude that delayed maturation doesn't mean better health and extended lifespan,


I don't recall anyone in this thread even suggesting otherwise. I certainly haven't. I've simply asked why his skin appears not to have aged. I'm not talking about his development. I'm talking about the fact that his skin appears not to have undergone any senescence. I'm really surprised I must say by the rationalizations and dodges going on here - it reminds me of the pro aging trance. So many straw men are being thrown around the place when all we want to know is this: Why does he have young looking skin?

#67 struct

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Posted 08 April 2009 - 02:57 AM

Yes, he looks like a teenager. It's not just the skin, but also the voice, his movements, smile, etc (looking at some of his videos)



#68 nowayout

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Posted 08 April 2009 - 11:10 AM

I don't recall anyone in this thread even suggesting otherwise. I certainly haven't. I've simply asked why his skin appears not to have aged. I'm not talking about his development. I'm talking about the fact that his skin appears not to have undergone any senescence.


I think you are confusing the hormonally driven changes in skin texture in a male's 20s with senescence. They are not senescence. (I am referring to the many 30 year olds who have firm wrinkle-free skin.) It would be just as silly to call a ten-year old's skin senescent because its texture is different from a newborn's.

#69 Ben Simon

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Posted 08 April 2009 - 01:09 PM

I don't recall anyone in this thread even suggesting otherwise. I certainly haven't. I've simply asked why his skin appears not to have aged. I'm not talking about his development. I'm talking about the fact that his skin appears not to have undergone any senescence.


I think you are confusing the hormonally driven changes in skin texture in a male's 20s with senescence. They are not senescence. (I am referring to the many 30 year olds who have firm wrinkle-free skin.) It would be just as silly to call a ten-year old's skin senescent because its texture is different from a newborn's.


Well if thats the case someone should get onto patenting a hormonal skin cosmetic. Could be bigger than hula hoops.

#70 nowayout

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Posted 08 April 2009 - 01:41 PM

Well if thats the case someone should get onto patenting a hormonal skin cosmetic. Could be bigger than hula hoops.


If you could get one that didn't penetrate systemically, which seems to be the main problem. Something like that could be great for hair loss.

#71 kismet

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Posted 08 April 2009 - 02:10 PM

It's strange how surprised some of you are, just seeing someone who apparently has a cogenital growth hormone disorder.
When in fact it wouldn't be surprising at all to see such a person age slower, as it is in agreement with all our animal models. Unfortunately, we can't tell if it really affects maximum life span (he is too young and we have no biomarkers of aging) and it certainly is not the first such case. Zvi Laron has documented many cases and speculated they might live longer, but his cohorts at least are old enough to show some meaningful results. Aubrey mentioned this very fact years ago. It's nice to see that a public figure could further our knowledge about GH-signalling & longevity but this ain't an exceptional or novel case.

Either way growth hormone manipulation is a very blunt and weak tool to increase lifespan (as you can see it reduces quality of life quite a bit). Only recently ourboros reported that FOXO3A polymorphisms (probably involved in IGF signalling) are associated with exceptional longevity in humans. It's definitely not enough to reach even the most modest goals of healthy life extension, though.

Edited by kismet, 08 April 2009 - 04:23 PM.


#72 maxwatt

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Posted 08 April 2009 - 03:53 PM

There are many possible types of "growth hormone defficiency" http://emedicine.med...923688-overview

Some may possibly be associated with increased life-span.

Pituitary growth hormone secretion is stimulated by growth hormone–releasing hormone (GHRH) from the hypothalamus and possibly by another signal, which may be stimulated by certain growth hormone–releasing peptides (GHRPs). Receptors for the GHRPs have been identified, and the natural ligand for these receptors has been determined to be ghrelin. Somatostatin secreted by the hypothalamus inhibits growth hormone secretion. When growth hormone pulses are secreted into the systemic circulation, insulinlike growth factor 1 (IGF-1) is released, either locally or at the site of growing bone. Growth hormone binds to a specific growth hormone–binding protein (GHBP) and circulates. This GHBP is the extracellular portion of the growth hormone receptor. IGF-1 binds to one of several IGF-binding proteins (IGFBPs) and circulates almost entirely (>99%) in the bound state. IGFBP-3 accounts for most of the IGF-I binding and this binding protein directly depends on growth hormone.

Growth hormone deficiency may result from disruption of the growth hormone axis in the higher brain, hypothalamus, or pituitary. This dysfunction can be congenital or acquired.

In 1992, a patient was described with a mutation in a transcription factor (POUF-1, also known as PIT-1), which resulted in familial growth hormone deficiency.2 As many as 14 different mutations have been described. In addition to growth hormone deficiency, affected individuals have had prolactin deficiencies and variable thyroid-stimulating hormone (TSH) deficiencies. Imaging of the pituitary gland usually reveals a hypoplastic or ectopic posterior pituitary.

Growth hormone deficiency with other hypopituitarism associated with inactivating mutations of the PROP1 (Prophet of PIT-1) transcription factor gene have been documented in reports. Patients with this mutation usually do not produce luteinizing hormone (LH) or follicle-stimulating hormone (FSH), and thus, do not spontaneously progress into puberty. They may also have TSH deficiency. Imaging of the pituitary gland of patients with PROP1 mutations may show either a small anterior pituitary or an intrapituitary mass.

Congenital growth hormone deficiency may be associated with an abnormal pituitary gland (seen on MRI) or may be part of a syndrome such as septooptic dysplasia (SOD) (de Morsier syndrome), which may include other pituitary deficiencies, optic nerve hypoplasia, and absence of the septum pellucidum; it occurs with an incidence of about 1 in 50,000 births. SOD may be associated with a mutation in the gene for another transcription factor, HESX1.

Acquired growth hormone deficiency may result from trauma, infections (eg, encephalitis, meningitis), cranial irradiation (somatotrophs appear to be the most radiation-sensitive cells in the pituitary), and other systemic diseases (particularly histiocytosis). Although most instances of isolated growth hormone deficiency are idiopathic, specific etiologies cause most growth hormone deficiency associated with other pituitary deficiencies. A reported 12-86% of children with apparent isolated growth hormone deficiency have sellar developmental defects.



#73 nowayout

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Posted 08 April 2009 - 05:17 PM

Some [types of growth hormone deficiencies] may possibly be associated with increased life-span.


Is there data available on the lifespan association?

#74 crayfish

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Posted 19 April 2009 - 10:35 PM

His skin is visibly photodamaged (unsurprising, difficult to avoid at his age). Look at the areas around his eyes, nose and mouth. There are also some pigmentary changes on his cheeks, some of which may be actinic lentigines. His skin looks okay for his age, but I have seen better and it certainly doesn't look like the skin of a teenager. Bear in mind also that his youthful looks underpin his career and he may use skin creams.

As for the youtube shots, webcams give everyone smooth skin.

It'd be interesting to know what mutation caused this condition. I wonder if he has problems with thermostasis.

Attached Files


Edited by crayfish, 19 April 2009 - 10:39 PM.


#75 mdma

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Posted 28 May 2009 - 08:19 PM

So what happens if he gets with a 14yo girl?


LOL he probably is
What happens if a 33 yo woman is seen dating him?

Some persons look really younger by nature, but that guy is pushing it tough

Im 25 and i get ID everywhere - legal age is 18 where i live - , so at 33 il look around early 20's i guess.

#76 Luna

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Posted 10 June 2009 - 05:25 AM

grr my long reply of speculations died due to the refresh button :(

I give up! but I wanted to also link to this article:

http://www.womensene...context/archive

It won't explain his voice due! unless he had been castrated or something.. it is possible he had an hormone disorder or an anti-depression medicine which rose estrogen at young age, fusing the bone's growth plate.

Again, not accounting for the voice!

But I was thinking, his voice isn't that high! children voice averages at 300HZ, Females at 200HZ and men at about 100-120 HZ
He could have his voice on the upper spectrum of man's voice because of his voicebox being developed but due to his sinus and mouth cavity it would rise and sound a bit childish still.
I am not sure! but he doesn't sound like a normal child and doesn't sound like a girl either..

Lack of growth hormone could probably explain both lack of bone growth and lack of sex features.. but! if it was that severe it would cause many other health problems.. I think!
And if it was lack of growth hormones, he'd probably be on treatment.. then again his parents might have not called to a doctor 20 years ago.. but they would if it would cause more problems due to growth hormone..

I was supposed to give up when the post got deleted.. :)

Edit: he is definitely aging! he is just not "growing".. still interesting.. but a lot less as there are plenty of known ways why a person would stop developing.. it's just a question of which label he gets!

Edited by Winterbreeze, 10 June 2009 - 05:27 AM.


#77 Proconsul

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Posted 14 June 2009 - 12:28 PM

The reality is that we don't know enough about this guy. He should definitevely be studied. Apparently he looks 14, but from a clip you can't exactly judge the real conditions of his skin. Nor whe know other physiological parameters of his that are related to aging. The absence of wrinkles by itself doesn't prove much. I'm 44, and I still can't see any wrinkles around my eyes or other area of my face, except the wrinkles over my eyebrows that I have always had since I was in my late teens. I have checked my wrinkles for years and I can't see any visible change. Still, my skin doesn't look as fresh as when I was 25 or even 30. Skin aging may be influenced by several factors. I have a thick, rather oily skin, which is good for slowing the formations of wrinkles. That doesn't mean that, for instance, my subcutaneous connective tissue isn't aging and that the proteins in the extracellular matrix aren't accumulating cross-links, as it happens when one gets older.

#78 TheFountain

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Posted 28 November 2009 - 12:31 PM

34 year old Andy Milonakis reveals the real reason why he looks 15.


Edited by TheFountain, 28 November 2009 - 12:33 PM.


#79 forever freedom

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Posted 28 November 2009 - 01:49 PM

lol

#80 immortali457

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Posted 28 November 2009 - 10:15 PM

WTF??????? LOL

#81 OneScrewLoose

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Posted 26 January 2010 - 11:19 AM

WTF??????? LOL



#82 Ben

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Posted 26 January 2010 - 02:39 PM

I love his "TEMPORARY" tattoo ><

#83 Dorho

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Posted 28 January 2010 - 05:58 PM

I don't think there's any reason to watch this guy in awe. His facial proportions and other characteristics look like that of a young boy because he has the congenital growth-hormone condition and his skin is in great condition probably because A) he's from Greece and greeks have typically thick skin like African and Indian people B) he probably doesn't spend too much time in the sun and C) the fat under his skin evens out wrinkles that would be otherwise visible.

Now if you compare this guy to someone other with thick skin like Samuel L Jackson (who is 61 years old) who has been a lot in the sun and who is not overweight, then you don't probably think the Milonakis case is so special after all:
Posted Image

#84 numbered

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Posted 28 January 2010 - 06:14 PM

I don't think there's any reason to watch this guy in awe. His facial proportions and other characteristics look like that of a young boy because he has the congenital growth-hormone condition and his skin is in great condition probably because A) he's from Greece and greeks have typically thick skin like African and Indian people B) he probably doesn't spend too much time in the sun and C) the fat under his skin evens out wrinkles that would be otherwise visible.

Now if you compare this guy to someone other with thick skin like Samuel L Jackson (who is 61 years old) who has been a lot in the sun and who is not overweight, then you don't probably think the Milonakis case is so special after all:
Posted Image


well im Greek and i can tell you that most greeks at 33 are wrinkled .Some less but some so much you would be surprized , probably sundamage and genes , so thick skin or not it depends on where you live and how much sun you are exposed to.Seeing that andy has some sort of a condition with growth hormone and his skin looks like that one can deduce that growth hormone plays significant role in skin aging. Samuels photo looks unreal. I like him.

#85 TheFountain

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Posted 28 January 2010 - 06:20 PM

hmm except that samuel L jackson doesn't look and sound like a 15 year old. Obviously growth and aging (or the outward appearance of such) are interrelated. Notice how men who take female hormones (thus preventing male growth patterns) look younger than many men in their age groups. I don't see how outward appearances do not indicate internal processes. It makes no sense to me.

Edited by TheFountain, 28 January 2010 - 06:21 PM.


#86 VidX

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Posted 07 February 2010 - 07:55 PM

Damn. Samuel looks great. I allways thought he's about 40..

#87 Matt

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Posted 07 February 2010 - 09:05 PM

Samuel does look great for his age....

andy still looks 15. practically every 30+ year old does not look or sound as young as andy.

#88 JohnD60

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Posted 16 February 2010 - 06:24 AM

I enjoyed this thread. Thank you for starting it. Would I want to trade places with Andy?...No. I am 15 years older than him but will probably out live him, as he will probably die of a heart attack in 10 years. But IMO his appearance is far outside the ordinary, and his bio-chemistry is worthy of study.

#89 Luna

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Posted 16 February 2010 - 07:07 AM

wow, Samuel L Jackson looks neat.

Umm.. Andy looks... like a very over-weight kid O_o
I really wonder what causes to have a good skin because the rest is just lack of development.

#90 pycnogenol

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Posted 27 February 2010 - 12:43 AM

I've seen Andy on TMZ after a rousing night of drink and debauchery and he no look 14! :-D

Edited by pycnogenol, 27 February 2010 - 12:43 AM.





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