Allotopic Expression & the "Mitochondrial Problem"

#91 John Schloendorn

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Posted 21 October 2006 - 08:35 PM

My point was simply that solving the mtDNA mutations problem would not necessarily make the other "deadly things" of SENS much easier.

I agree. This is why we differentiate between seven relevant classes of damage after all.

#92 Mark Hamalainen

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Posted 21 October 2006 - 08:53 PM

Do I suffer from brain blockage or am I right in thinking that this decline cannot be a result of "mitochondriogenic" damage?

You're attacking a straw man. Nobody claims that allotopic expression will eliminate aging of the mitochondria entirely.

However, there is no research that I am aware of that seeks to design an intervention to address the age related depletion of the stem cell niche.

Thats a fairly obvious experiment Prometheus, and I will be happy to see it attempted, especially with some SENS modifications included in the new stem cells. Stem cell research does not lack for funding though, and I imagine this experiment will be attempted soon with or without the MF's help.

#93

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Posted 22 October 2006 - 02:42 AM

SENS modifications included in the new stem cells

Such as?

#94 Mark Hamalainen

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Posted 22 October 2006 - 10:08 PM

Such as?

I'll provide the allotopically expressed mitochondrial genes. John'll hook us up with the genes for some enhanced lysosomal enzymes. Just give us 3-4 years.

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