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N Methyl D Aspartic Acid (NDMA) as a nootropic?

ndma

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#1 Peak Noots

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Posted 29 May 2013 - 01:55 PM


We have been looking into this compound. N Methyl D Aspartic Acid converts into the neurotransmitter that triggers the NDMA glutmate receptors. We found loads of research on it triggering GH, LH and Test production but nothing on it as an actual nootropic. Would be interested to hear peoples opinions.

N Methyl D Aspartic Acid seems to be non neurotoxic in lower dosages. Has anyone tried this amino acid derivative?

Thanks,
Peak Nootropics

#2 JohnnyP

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Posted 29 May 2013 - 02:34 PM

I have only used regular DAA before does NDMA have the same potential for affecting prolactin levels?

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#3 Ultravioletbllc

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Posted 30 May 2013 - 03:25 PM

I have used high dosage daa for lh and free test and used a mix of low dose (750 mg) daa 125 mg glutamic acid 2-6 grams glycine and huperazine (50-125mcg)in conjunction too activate nmda, since some Daa converts into nmda( one company already uses it as a free test booster however it caused me unreal anxiety at any dosage) I would assume it is nootropic in nature except I'm gonna assume high dose nmda too be overly excitory and therefore not a true nootropic

#4 kurdishfella

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Posted 12 November 2019 - 06:39 PM

bump, has anyone tried this?

 

https://www.amazon.c...d/dp/B014OML6WK

 

https://en.wikipedia...D-aspartic_acid

 

Doesn't BDNF,NGF, ACTH/stress etc and perhaps adrenaline/noradrenaline ,dopamine , serotonin and many others activate NMDA receptors?

 

Does taking Pure NMDA even work orally? half life?


Edited by farshad, 12 November 2019 - 06:41 PM.


#5 Targz

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Posted 25 July 2020 - 09:10 AM

PLEASE DO NOT TAKE NMDA AS A NOOTROPIC. NMDA is a known neurotoxin. Tonically activating NMDA receptors will create so many problems in the brain. Phasic activation of these receptors, at least the synaptic population, is what is responsible for LTP. Tonic activation will disrupt this. Taking NMDA will also mimic excitotoxicity and LTD, and could trigger seizures and neurodegeneration, or at the very least make you anxious and depressed. DO NOT, under ANY circumstances, INGEST NMDA FOR ANY REASON. NMDA is used merely as a research tool to study ion channel dynamics. Read some studies about what happens when rats were administered NMDA. If you want to enhance NMDA function there's plenty of nootropics to do so, such as piracetam, which increases several NMDA receptor subunits in specific, beneficial areas of the brain, or even more obscure ones like D-cycloserine, a much stronger drug and PAM of the NMDA receptor with quite a few side effects. Hell, you could even ingest glycine or d-serine or both, or more preferably FGL, just NOT NMDA. Please.


Edited by Targz, 25 July 2020 - 09:10 AM.

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#6 kurdishfella

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Posted 26 July 2020 - 10:27 PM

PLEASE DO NOT TAKE NMDA AS A NOOTROPIC. NMDA is a known neurotoxin. Tonically activating NMDA receptors will create so many problems in the brain. Phasic activation of these receptors, at least the synaptic population, is what is responsible for LTP. Tonic activation will disrupt this. Taking NMDA will also mimic excitotoxicity and LTD, and could trigger seizures and neurodegeneration, or at the very least make you anxious and depressed. DO NOT, under ANY circumstances, INGEST NMDA FOR ANY REASON. NMDA is used merely as a research tool to study ion channel dynamics. Read some studies about what happens when rats were administered NMDA. If you want to enhance NMDA function there's plenty of nootropics to do so, such as piracetam, which increases several NMDA receptor subunits in specific, beneficial areas of the brain, or even more obscure ones like D-cycloserine, a much stronger drug and PAM of the NMDA receptor with quite a few side effects. Hell, you could even ingest glycine or d-serine or both, or more preferably FGL, just NOT NMDA. Please.

I already did and nothing happened, overreaction on your part.



#7 Targz

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Posted 27 July 2020 - 01:35 AM

I already did and nothing happened, overreaction on your part.

 

 

Perhaps the absorption was sub-par. Regardless, I'd look into NMDA PAMs before you mess with pure NMDA. It will not give you what you seek. Perhaps your neurochemistry can tolerate it but for many it could be potentially toxic. We're talking about a known neurotoxin here with no known therapeutic benefits, no reason to not be cautious.



#8 kurdishfella

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Posted 27 July 2020 - 02:07 AM

Perhaps the absorption was sub-par. Regardless, I'd look into NMDA PAMs before you mess with pure NMDA. It will not give you what you seek. Perhaps your neurochemistry can tolerate it but for many it could be potentially toxic. We're talking about a known neurotoxin here with no known therapeutic benefits, no reason to not be cautious.

dopamine and glutamate are neurotoxin aswell I don't see people dropping dead.



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#9 Targz

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Posted 27 July 2020 - 02:51 AM

dopamine and glutamate are neurotoxin aswell I don't see people dropping dead.

 

You can't get those across the BBB. Plus, even if you could, there's mechanisms in place to prevent toxicity, such as mGluRs, astrocyte reuptake, and the DAT/NET. With pure NMDA, there's none. It's not just, 'more NMDA = more better memory,' we're talking about distinct effects relating to tonic vs phasic signalling, with synaptic phasic signalling mediating LTP and extrasynaptic tonic signalling mediating excitotoxicity.







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