There has never been a human study on the pharmacodynamics of oral NMN. So we don't know how it is absorbed or how our body is using it.
Actually there has been. https://www.egaceuti...pleted-studies/
That is not a peer reviewed scientific study. That is a marketing report done by a company selling a supplement with no clinical research in humans to back their claims. In addition the company uses the age old technique of burying doubt in a pile of unrelated claims too large for anyone to refute.
Back on topic for this thread . . .
I would like to add unscientific anecdotal evidence to this thread because I find the opening remarks offensive and ill informed.
I first posted on this website in February: first post
As a recap, I and my family suffer from a late onset incurable and fatal neurodegenerative disorder called Spinocerebellar Ataxia type 1 (SCA1). This type of illness falls into a category know as polyglutamine disorders which includes diseases like Huntingtons, OPMD, and multiple forms of SCA. In these disorders the build up of mutant proteins in the brain causes cellular death which results in the neurodegeneration. Since learning of my affliction I have been researching every mode of possible cure. About a year ago my research led me to 3 supplements of interest: trehalose, niagen, and pterostilbene. Initially I started my father, my aunt and myself on just trehalose, but then I quickly added niagen, and later pterostilbene. My father and my aunt are limited by their age and the damage that has already been done in their bodies so their results were restricted to a cessation of progression and being able to take a few steps with a walker after having only used a wheelchair for more than a year. I initially reported improvements in balance and endurance, but have since recognized other changes that were in fact symptoms of ataxia that are now gone entirely. Those symptoms that are now gone included; balance issues, diminishing hand writing skill, difficulty with alliteration, fatigue, loss of strength in my legs, and sleeplessness. I have also increased my overall regimen to include: diet low in calories and meat, and high in cruciferous vegetables, exercise daily to include 30 mins alternating between weight training, running, and yoga, plus supplements of 40g trehalose in 2 cups of coffee plus sniffing about .3g, niagen 500 mg and pterostilbene 250 mg before bed, plus 2 cups of green tea daily. In addition to my experience, I have been sharing my regimen with other sufferers of Parkinson, HD, and ataxia and am now in email contact with about 1 dozen people who report similar results to my own. Lastly, I am in direct contact with Dr. Brenner of Chromadex and Dr. Jeremy Schmahmann of Harvard Med in establishing an n=1 study of biomarkers in my brain to determine if there is evidence of cellular changes in toxicity levels from the mutant ATXN-1 protein caused by my disorder.
This is anecdotal information and the information is clearly confounded by the multiple aspects of my regimen, but I vehemently disagree with the OPs opening remarks and will simply add: NR is NOT trash.
However, I will also add that for a normal healthy individual NR will likely have little if any noticeable benefit although it may well confer longterm benefits not yet fully understood, but that remains to be shown.
For more detailed information on my regimen and my research you can go to Healthunlocked.com/ataxia and search "sunvox"
Edited by 2Sunny, 14 November 2017 - 01:41 PM.
This topic is locked
