There's a fairly recent interview on Stemtalk with Dr. Tommy Wood:
https://www.ihmc.us/...alk/episode-48/
The whole thing was good, but there was one idea in particular he mentioned that I transcribed below.
At 0:45:10 they asked the question:
Do you have any thoughts on the supposedly lifespan or healthspan enhancing supplements, for example NAD or Nicotinamide Riboside to improve NAD+ levels?
[..earlier portion of answer elided..]
0:46:50
There's going to be a potential issue where people are trying to drive the fasting physiologies (that's higher levels of NAD+) in the chronically fed state (which is most sick people). And there's a similar... people will have heard of resveratrol... which was supposed to be this life enhancing or life-extending supplement. And it's activated, or activates the pathways associated with fasting. They recently showed in a clinical trial with type 2 diabetics, that high doses of resveratrol seem to make it worse. I think that's because you've taken people who are chronically fed, or over-fed (that's part of the disease process) and you try to drive fasting physiology at the same time, and you get a negative interaction. So to get the most benefit out of those supplements you also need to do the stuff that's associated with those processes which would involve sleep, occasional fasting and carbohydrate restriction.
I've had similar thoughts, and have been attempting to divide any supplements into at least two categories: those for anabolism/feasting, and those for catabolism/fasting. And how these two phases map onto, say, Turnbuckle's fission/fusion protocol.