Anyone considering supplementing with Urolithin A?

i dunno. what are your qualifications to make one and to be a trusted source?

I can make ellagic acid cyclodextrin complex available to you guys probably.
I believe urolithin a is a metabolite.

I'm trying to think of a reason we'd want to encapsulate ellagic acid in cyclodextrin.

We don't want ellagic acid per se, we want urolithin A.  We want bacteria in the gut to metabolize the ellagic acid into urolithin.  If anything, complexing it with cyclodextrin might interfere with or prevent that process.  Typically you complex things with cyclodextrin when you're trying to protect them to get them through the digestive tract.  That's not what we want at all there. 

I think I partially agree. I do agree that it may prevent conversion but I disagree that we use cyclodextrins to protect from the gut. Generally we would use a cyclodextrin complex to improve aqueous solubility.
This improves bioavailability not just orally but frequently also intranasal, sublingual, rectal, occular, transdermal etc.

I do think your right though, probably not the best option. I just happened to have some handy.

2 other options then.

A high percentage standardized ellagic acid extract

Synthetic Urolithin a. We can definitely make this but I dont know the costs involved. Might be that unless we wanted a significant volume price would be unreasonable.

Edited by Brundel, 01 November 2019 - 04:55 PM.

I think I partially agree. I do agree that it may prevent conversion but I disagree that we use cyclodextrins to protect from the gut. Generally we would use a cyclodextrin complex to improve aqueous solubility.
This improves bioavailability not just orally but frequently also intranasal, sublingual, rectal, occular, transdermal etc.

I do think your right though, probably not the best option. I just happened to have some handy.

2 other options then.

A high percentage standardized ellagic acid extract

Synthetic Urolithin a. We can definitely make this but I dont know the costs involved. Might be that unless we wanted a significant volume price would be unreasonable.

The things I would be most interested in are:

1.) Pure Urolithin A.  Either a refined naturally produced product or a synthetic version.

2.) A probiotic containing gordonibacter urolithinfaciens which will convert ellagic acid into Urolithin A.

At the right price, I'd be more interested in the first option.  But, since this is a supplement you'd want to take more or less continually cost is important.  If I couldn't get Urolithin A at an affordable cost, then option 2 looks better.

Hmm, Im not super familiar with gordonibacter urolithinfaciens.

Perhaps we could make both though and create a single product.

If you guys are willing to put the work in Ill see about making it happen. Maybe we can setup a google drive folder and start dumping studies into it.

2 Folders Uro a and Gordon.

We would need to make a significant batch of both probably so maybe we can discuss how many people are actually interested.

And Finally, maybe Admin or a Mod could contact me so we can discuss the rules and regulations of this forum. I dont want to step on anyones toes or break any forum rules.

When I say both I mean a single product with Ellagic and Gord.

Or synthetic UroA

what brand are you selling online?

i appreciate your enthusiasm to get this going as supplement. it will be quiet novel out there as nothing like this exists yet. but i dont see any profit from this. seriously, its not like people out there are waiting for something like this to show up and run and buy it. i would think maybe if you add curcumin, vitamin d, fish oil, cbd and whatever else thats a huge seller as supplement to the mix and viola. we might have something going on here.

Oh I know. I should not have used the term product. Habit.

This isnt for product development but just to give you guys access.

I already own an anti aging company that has over a dozen patents including senolytics.

The first will likely be available within 6 months. We are running a bunch of trials to ensure efficacy is where we want it to be.

Within 18 months I suspect we will have 3 to 5 of these products with the goal of 8 for a complete anti aging therapy.

This is the product that has ellagic acid in it. Again if there is an issue with me posting things like this let me know and Ill delete and refrain.

The goal isnt to promote the products.

https://www.blacklio...ct-page/rebirth

dont worry about promoting here. this place is mostly children playing with the rating system involving emojis. but, anyway, you still havent shared what company or product you work for? im curious to know now even more because i asked you two times already without much avail :/

dont worry about promoting here. this place is mostly children playing with the rating system involving emojis. but, anyway, you still havent shared what company or product you work for? im curious to know now even more because i asked you two times already without much avail :/

His company and the product is in the link. And I don't believe promotion is allowed here, esp. with all the children playing around here  . He needs to ask the mods, at a minimum.

I'm very interested in your Urolithin A product.  

Anything you can tell us about dose and price?

I can make ellagic acid cyclodextrin complex available to you guys probably.
I believe urolithin a is a metabolite.

Urolithin is a product of gut bacteria digesting ellagic acid, if and only if you have the right gut bacteria.

Hence the desire to get Urolithin A directly or at least obtain a probiotic with something that will properly digest the ellagic acid, i.e. gordonibacter urolithinfaciens.

Oh I know. I should not have used the term product. Habit.

This isnt for product development but just to give you guys access.

 

I already own an anti aging company that has over a dozen patents including senolytics.

The first will likely be available within 6 months. We are running a bunch of trials to ensure efficacy is where we want it to be.

Within 18 months I suspect we will have 3 to 5 of these products with the goal of 8 for a complete anti aging therapy.

 

This is the product that has ellagic acid in it. Again if there is an issue with me posting things like this let me know and Ill delete and refrain.

The goal isnt to promote the products.

https://www.blacklio...ct-page/rebirth

Did you ever introduce your urolithin A product?

Looks like Amazentis decided to make a supplement.

"After a decade of research and development, Amazentis is now ready to introduce Timeline. The revolutionary nutrition product is based on the company’s lead ingredient Mitopure which helps to curb age-associated cellular and muscular decline. Timeline will be available in the United States in the first half of 2020."

Supposed to be launching in a couple of months

https://www.timelinenutrition.com/

Good info. Let's hope they keep to their schedule.

Did you ever introduce your urolithin A product?

No sir, current interest doesnt validate the production volume costs.

If you guys are interested I can make available or currently have-

Quercetin niacin co crystals

Tyrosol

BF7

11% salidroside

60% Forskolin

25% chloorogenic acid.

Have all of these presently. Most interesting for you guys would likely be the co crystals of quercetin, tyrosol and BF7

Will list on site if you guys can get at least 5x people interested.
 

Just gonna put this out there as well.

Within a year there will be a viable set of legit longevity and healthspan solutions available.

If you are on this forum you likely believe lifespan can be increased. We are there.

I wont market or advertise or speak about brands. You will see it happen Im sure but I can tell you for certain that its worth getting excited about. No more trying to patch together solutions from non existing or dubious sources.

No more underdosed products

No more products without efficacy or validity.

Legit patented solutions.

Just gonna put this out there as well.

Within a year there will be a viable set of legit longevity and healthspan solutions available.

If you are on this forum you likely believe lifespan can be increased. We are there.

I wont market or advertise or speak about brands. You will see it happen Im sure but I can tell you for certain that its worth getting excited about. No more trying to patch together solutions from non existing or dubious sources.

No more underdosed products

No more products without efficacy or validity.

Legit patented solutions.

That will be interesting assuming there is data to back up the claims.

No sir, current interest doesnt validate the production volume costs.
If you guys are interested I can make available or currently have-
Quercetin niacin co crystals
Tyrosol
BF7
11% salidroside
60% Forskolin
25% chloorogenic acid.

Have all of these presently. Most interesting for you guys would likely be the co crystals of quercetin, tyrosol and BF7
Will list on site if you guys can get at least 5x people interested.

BF7 as in Brain Factor 7? I am very interested in that.

Yup.

Have about 50kg here.

Solo or mixed with

centella

tyrosol

salidroside 11%

caff50mg/cap

If for some reason this is against the rules please let me know.

That will be interesting assuming there is data to back up the claims.

Indeed.

I think we have the science available today to at least begin combating old age.

My guess is for every 10 years moving forward we should be able to add 10 years to our lifespan.

For now its about cleanup and repair.

maintenance.

Disclosure: I'm an employee of Amazentis. I've joined the forum to answer questions and facilitate the conversation where we feel we have something helpful to contribute. 

Is Mitopure Urolithin A an extract? Is it made from pomegranates or berries? No. Pomegranates and other foods including select nuts and berries do not contain Urolithin A. These foods contain precursor compounds known as ellagitannins. When you eat these foods your gut may or may not be able to convert the ellagitannins into the Urolithin A bioactive depending on whether you have the right composition of bacteria. Even those who are able to naturally metabolize into Urolithin A do so to greatly varying degrees. That's why we created an isolated form of Urolithin A, called Mitopure. It is synthetic but molecularly and functionally identical to natural Urolithin A and is the first commercial product to offer precise doses independent of diet and microbiome diversity and complexity. In a recent clinical study we showed that even for those people who are able to naturally produce Urolithin A from dietary sources, 500mg of Mitopure delivers >6X Urolithin A when compared to 8 ounces of 100% pomegranate juice (with 16X less sugar) over 24 hours. The Timeline powder product includes 500mg of Mitopure in each daily dose. The berries and pomegranate whole fruit are there purely to offer a great tasting food product that you can enjoy with your daily breakfast - mix into a yogurt, smoothie, cereal, oats and much more.  

What is the right dose to take? We recognize that price is an important factor but after over 10 years of research and development our priority is to commercialize products and doses that have real clinical evidence. In our first in human clinical study we tested 250mg, 500mg and 1000mg doses over 4 weeks (ref below). The primary endpoint of that study was safety but we also looked at pharmakinetics (absorption, distribution, excretion etc..) and the impact on biomarkers of mitochondrial and muscular health. Based on that first human study we took the 500mg and 1000mg and administered them to participants in a double-blind placebo-controlled trial over 4 months. We recently shared topline data that shows that 500mg/day of Mitopure can significantly improve leg muscle strength in overweight 40-65 year olds when compared to placebo. 

What is the pre-clinical and clinical evidence? According to PubMed there have been over 100 studies since 2012 exploring the potential benefits of Urolithin A across areas including brain health, muscle health, inflammatory bowel disease and other conditions. 

Amazentis is the first to run clinical trials in humans. Here is the list of our pre-clinical and clinical research to date:

Value of our product: A 2019 study by the AARP found that "Supplements for brain health appear to be a huge waste of money for the 25 percent of adults over 50 who take them". We chose to take a different path - one where we've we pioneered a new mechanism of action (mitophagy) and developed a novel nutrient that has rigorous science and clinical evidence. We sell a daily 500mg dose for as low as $2.83 if you sign up for a 12 month plan or $3.33 for a 4 month plan. Why a 4 month minimum? Because our clinical studies show that impacting muscle function takes time and regular daily use - we recommend 500mg/day for a minimum of 4 months. We've introduced a $10 sample so you can try the product (for taste and experience) before you decide to commit and we credit back the $10 if you decide to purchase a plan. 

Edited by Mind, 25 November 2020 - 03:12 PM.

If I had the means I'd find some way to isolate this bacteria and synthesize Urolithin A and find some way to isolate it. I don't know what kind of equipment that takes. Probably more than I can afford.

MicrobiologyResearch.org

"We isolated a strain capable of transforming EA to urolithins from the faeces of a healthy female, and its metabolic characteristics were analysed (data not shown) in Spain. The sample was processed for isolation of bacteria within 2 h. The sample was diluted 1/10 (w/v) in nutrient broth (Oxoid) supplemented with 0.05 % l-cysteine hydrochloride and homogenized by stomacher in a filter bag. The filtered suspension was diluted further in the same broth medium, and aliquots were plated on DRCM agar (Merck). The isolation procedure and incubation of plates were carried out under anaerobic conditions in an anaerobic chamber (Don Whitley Scientific) with an atmosphere of N2/H2/CO2 (80 : 10 : 10) at 37 °C. "

This was done back in 2014, maybe not enough hype surrounding it yet.  Seems like it is imminently doable.

Edited by Gal220, 06 September 2020 - 07:20 AM.

"UA significantly increased ATP and NAD⁺ levels in mice skeletal muscle (...) Angiogenic markers such as VEGFA and CDH5 which were blunted in skeletal muscles of 28 week old mice were found to be upregulated upon UA supplementation. Such augmentation of skeletal muscle vascularization was found to be bolstered via Silent information regulator 1 (SIRT1) and peroxisome proliferator-activated receptor-gamma coactivator-1-alpha (PGC-1α) pathway. Inhibition of SIRT1 by selisistat EX527 blunted UA-induced angiogenic markers in C2C12 cells. Thus this work provides maiden evidence demonstrating that UA supplementation bolsters skeletal muscle ATP and NAD⁺ levels causing upregulated angiogenic pathways via a SIRT1-PGC-1α pathway (...)

Such increased levels of NAD⁺ upon UA supplementation was comparable to the effect obtained by supplementing nicotinamide riboside, precursor of NAD⁺, at a five-fold higher dose"