Question About GABA & CRH

This study: https://www.ncbi.nlm...pubmed/10723009
''mRNAs for the alpha1 and beta2 subunits of the GABA(A) receptor were detected within 53.3% and 65.7% of PVN CRH neurons, respectively.''

Then this study: https://www.ncbi.nlm...pubmed/12480126
''Self-inhibition of GABA cannot stop all transport into the brain, and the highest recorded value of inhibition has been 80%''

If someone takes say an GABA-A agonist like Xanax, how much CRH inhibition will there be? 53,3%, 65%,7 or 80%?
Like how much inhibition can GABA on its own have? Is there a limit or can GABA inhibit 100% of the CRH?
Lets say GABA inhibits 80% and I take a supplement called St John's wort which has been shown to reduce CRH by 20% ( https://www.ncbi.nlm...pubmed/11526469 ), would that mean taken together it would be 100% inhibition?
At the moment im looking at a hormone called 5a-dhp that is a precursor to allopregnanolone which is an GABA-A modulator, im curious how much it will help with blocking CRH, (cortisol releasing hormone) if it is only 80% since that is only as much as your BBB (blood brain barrier) allows? And if so would combining it with St John's wort increase it from 80% to 100% so you are at a constant normal CRH base.
Also make it clear it is the hypericin content not Hyperforin that decreases CRH:https://www.ncbi.nlm...pubmed/12865894

I hope this made sense... im not looking for medical advice im just curious how much CRH GABA can be allowed to block.

nobody knows what im talking about?