https://academic.oup.../mcy118/5049820 1. Introduction
Coffee is one of the most frequently consumed beverages worldwide, and has gained special attention in relation to its beneficial effects on several chronic diseases, specially type 2 diabetes mellitus (T2DM).1 Coffee is a complex beverage composed of numerous bioactive substances, such as caffeine, phenolic compounds, including chlorogenic acids (CGA), and nutrients (minerals and vitamins). Collectively, coffee exerts functional and beneficial effects on human health.2 Epidemiological studies link moderate consumption of coffee with a reduced risk of developing T2DM. This association has been shown in several studies with different populations showing a consistent dose-response effect.3, 4, 5, 6, 7, 8, 9
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