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Resveratrol brand and formulation differences

resveratrol blood sugar piperine

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#1 Kimer Med

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Posted 20 January 2019 - 10:24 PM


Although the probable anti-aging aspects of Resveratrol are great, my main motivation for taking it is actually for blood sugar (BG) management (I'm pre-diabetic / Syndrome X). I've been using it for about 10 years now.

 

I take 500 mg Biotivia Transmax, Trans-Resveratrol, once/day with food. This formulation also includes Polydatin extract (5 mg) (a Resveratrol precursor) and Piperine (5 mg).
 
Over the years, I've tried a few different brands, and have also taken periodic breaks.
 
One aspect of using it for BG management is that effectiveness is easy to measure with a blood glucose meter. 
 
There can be a significant difference from one brand to another. For example, I've tried Bluebonnet and a Now Foods mix with Pterostilbene for a few months each, and both had almost no effect on my BG. Returning to Biotivia immediately re-established lower and more stable BG measurements.
 
If effectiveness varies on the BG side, it will certainly vary for anti-aging effects, as well.
 
I'm not sure if the differences are due to the purity of the trans-Resveratrol itself, or if it's related to the additives. Piperine, in particular, has been reported to significantly aid absorption.
 
I would be interested in hearing from others who may have tracked their Resveratrol supplementation in similar ways, and whether there are other brands / formulations / suppliers I should consider. Biotivia has been great for me, but it's also expensive.
 
I also wonder if some of the adverse effects reported by R users may be due to ignoring or not understanding the BG effects. If your BG is already on the low side, it's possible that taking R could make you feel pretty lousy, especially with a high dose. Taking it before bed could be particularly annoying, since low BG can cause an adrenaline spike, which can then wake you up (this even happens with a glass of red wine, which contains R).

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#2 Oakman

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Posted 21 January 2019 - 04:34 PM

I've been following Dr Sinclair's R recommendations recently. But I got tired of spending too much money expensive pill versions of R, like your Transmax. Finally found a good, 100% pure, no filler, 100% trans-R powder product from a small supplier, CurEase, and their 60 gram powder packet for as low as $30 in qty, $37 single packet, vs (and I'm not just picking on your Transmax - just an example) which is $40 for 30 grams on Amazon. I also have reservations about taking piperine, as it affects overall supplement absorption and breakdown in the liver. Not so important if you take one supp, but if you take others, do you want them ALL to be affected? Likely not.

 

Glad your BG is under control and R helps. If you really like your R with extras, perhaps consider making your own from its components. Should save considerable $


Edited by Oakman, 21 January 2019 - 04:36 PM.

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#3 Kimer Med

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Posted 21 January 2019 - 07:15 PM

Good point about piperine.

 

I'm not 100% sold on the "extras." All I know is that several brands without the extras don't work very well. However, that could be from low purity or various other things, and may not have anything to do with the extras. I guess that's one of the things I'm trying to figure out.

 

I suppose one way to do it would be to use tested, known-high quality R powder, and compare results against what's available from capsule suppliers.

 

Shipping to New Zealand for CurEase (direct or through Amazon) is on the high side ($25), but I'll keep them in mind. Are there other reputable suppliers I should consider?

 



#4 The Beauty of Peace

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Posted 25 March 2019 - 05:24 PM

Have you tried trans-resveratrol sold on Amazon? 

 

Biotivia Transmax is unaffordable  :|o



#5 Chrys

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Posted 31 March 2019 - 02:06 PM

Has anyone used Terraternal's R?

 

They say their product is of the highest purity...price also high.

 

https://www.terrater...l-50/557/3.aspx



#6 brosci

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Posted 28 September 2019 - 06:32 AM

How do Reserveage / Nutrabio compare to these options? Or LEF Optimized Resveratrol?

 

I also saw Pure Encapsulations has an emulsified version.



#7 Oakman

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Posted 28 September 2019 - 02:05 PM

How do Reserveage / Nutrabio compare to these options? Or LEF Optimized Resveratrol?

 

I also saw Pure Encapsulations has an emulsified version.

 

From Amazon...

 

Nutrabio - From the label, 500 mg (from 800 mg/capsule) trans-R. So in the 60 capsule size you get 30 grams trans-R for $62.95 or $2.10/gram

Reserveage - From the label, 250 mg trans-R (from 500 mg/capsule). In the 150 capsule size you get 37.5 grams trans-R, or $ .93/gram

LEF Optimized Resveratrol - From the label, 250 mg/capsule (plus several other ingredients). In the 60 capsule size you get 15 grams trans-Resveratrol or $1.76/gram

 

Here's a good (bad) example of what to be suspicious of...

 

aSquared -  This is suspect for a couple reasons and a good example of a brand that doesn't seem to want to say exactly what's in the capsule. 1) they do not say trans-R, at all. It could be, but unlikely because.... They mention all the various 'names' for R, but again never mention the one we want, trans-R. The ad is full of superlatives, 100%, extra strength, high potency, etc. BUT - one of their images shows what's inside the capsule and it is dark brown. Pure trans-R is a white crystal. Oops!

 

And my personal fav...

 

Curease - From the label, 100% trans-resveratrol. For 60 grams powder $ .67/gram

 

If you (just) want capsuled trans-R it looks like about $1/gram is reasonable, if you don't mind powder, or make your own capsules, well, you can get good product cheaper.

 

Pure Encapsulations VESIsorb - This is different and interesting, but at only 100 mg/capsule, the 90 capsules size will get you R at $14.60/gram. Pretty rich, but...


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#8 sedentary

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Posted 05 October 2019 - 12:04 AM

i get my resveratrol from wine but im trying to switch to caps because wine becomes expensive over time and also it contains alcohol. not sure if its the resveratrol content or what exactly, but after a night of drinking wine, i end up next morning with super low blood sugar and feel like passing out. could it be that perhaps its overloading yourself on sugar all night (wine being high on sugars) and you kind of burn out by morning seeking more sugar? or is it some of its contents resveratrol (as it is too low) + other polyphenols causing this?


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#9 brosci

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Posted 15 October 2019 - 08:18 PM

i get my resveratrol from wine but im trying to switch to caps because wine becomes expensive over time and also it contains alcohol. not sure if its the resveratrol content or what exactly, but after a night of drinking wine, i end up next morning with super low blood sugar and feel like passing out. could it be that perhaps its overloading yourself on sugar all night (wine being high on sugars) and you kind of burn out by morning seeking more sugar? or is it some of its contents resveratrol (as it is too low) + other polyphenols causing this?

 

Red wine is a pretty poor source of resveratrol.

 

From https://www.ncbi.nlm...les/PMC4942868/ -- "The average red wine can be expected to contain ∼1.9 ± 1.7 mg trans-resveratrol/L."

 

One capsule of resveratrol by contrast provides 250mg - 500mg. Sinclair goes through a gram a day -- that's 100+ gallons worth.



#10 sedentary

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Posted 16 October 2019 - 02:28 AM

who is this sinclair guy everyone keeps mentioning. i checked wikipedia and it comes up with two musicians.

anyway, not sure if i want to take such high dose resveratrol as it is toxin protecting plants from fungi and other detriments. there is a good reason human body doesnt absorb much of it and it doesnt allow it to stay in your system for too long. its benefits are obviously indirect by your body re-adjusting to its toxicity and raising its defenses. such situation its likely the association with life extension.

but ill stick with wine. who is the person who disliked my intake of wine and why? im still trying to figure out what is it in wine that lowers my blood sugar levels so severely. if its not the resveratrol which is minute amounts, what else is it??


Edited by sedentary, 16 October 2019 - 02:29 AM.

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#11 Castiel

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Posted 18 November 2019 - 10:46 PM

who is this sinclair guy everyone keeps mentioning. i checked wikipedia and it comes up with two musicians.

anyway, not sure if i want to take such high dose resveratrol as it is toxin protecting plants from fungi and other detriments. there is a good reason human body doesnt absorb much of it and it doesnt allow it to stay in your system for too long. its benefits are obviously indirect by your body re-adjusting to its toxicity and raising its defenses. such situation its likely the association with life extension.

but ill stick with wine. who is the person who disliked my intake of wine and why? im still trying to figure out what is it in wine that lowers my blood sugar levels so severely. if its not the resveratrol which is minute amounts, what else is it??

 

Sinclair is David Sinclair, a harvard researcher who discovered that resveratrol was a calorie restriction mimetic and activated a sirtuin in yeast.

 

As for the body processing it, some have said the liver is not eliminating it but making it more accessible to the rest of the body, and that it is converted back into resveratrol in cells and tissues.

 

Fat appears to make it significantly more soluble.

Optimal dosing remains to be seen, but it appears to have benefits even at moderate to high doses.


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#12 sedentary

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Posted 19 November 2019 - 11:48 PM

ok i see. thanks for giving this information. i suppose in a world where people are obese and eat so excessively all the time it sounds like a good candidate for good health. but would resveratrol be any positive for human race in the beginning of evolution when we barely survived with little to no food? man, that stuff would have been a major poison. im pretty sure even now its probably not too good for you and i stand by the belief that the reason the body doesnt absorb and keep it well inside IS exactly that its a toxin! im really not a supporter of it. i noticed when i was drinking tons of wine how it made me turn into skeleton. and yes, i was overeating having bad lifestyle and wine completely stripped me naked. i always assume its the resveratrol. it burned all my fat stores. to this day i cannot see that as positive.


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#13 Bocca

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Posted 29 November 2019 - 05:36 AM

Did anyone find a white powder version of Resveratrol?  I've tried a few and they have all been brown (aSquared being one)

 

I read that brown resveratrol is basically oxidised (by light) and it should be white for maximum bioavailability

 

 

 

 

 



#14 Oakman

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Posted 29 November 2019 - 05:43 PM

Did anyone find a white powder version of Resveratrol?  I've tried a few and they have all been brown (aSquared being one)

 

I read that brown resveratrol is basically oxidised (by light) and it should be white for maximum bioavailability

 

See post #7 above, for example, Curease is a white fluffy powder, ostensibly 100% pure trans-R. Better to pay and get what you need, rather than get scammed by vendors like aSquared, who is selling ground plant root material and calling is R, when in fact it contains an unknown % of trans-R or perhaps none, they don't specify. 

 

https://megaresverat...ealth-benefits/

 

Remember, if the Supplement Facts label does not clearly indicate the amount (or percentage) of trans-resveratrol content, then there is no way of knowing the product purity content, or if it offers any health benefits.
 
A classic example is a “resveratrol” product sold on Amazon that claims to be “100% Pure Resveratrol – 1000 mg Per Serving – Max Strength,” at an extremely low price. Despite its “purity” claim, the “Supplement Facts” label does not indicate trans-resveratrol content, and thus, there is no way to know the actual purity of this product. Although the seller claims the product “has been third-party tested,” neither the testing certification nor a COA (Certificate of Analysis) is posted or available. The price is too good to be true.
 
Every Supplements Facts label should indicate both the “total product” content AND the “trans-resveratrol” content. By providing both values, we can calculate the actual purity of the product in question. For example, a 50% pure product should be indicated on the label as “Resveratrol (Polygonum Cuspidatum Root): 500 mg Yielding 250 mg Trans-Resveratrol.” Or, “Standardized to 50% Trans-Resveratrol.”



#15 brosci

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Posted 29 November 2019 - 07:48 PM

See post #7 above, for example, Curease is a white fluffy powder, ostensibly 100% pure trans-R. Better to pay and get what you need, rather than get scammed by vendors like aSquared, who is selling ground plant root material and calling is R, when in fact it contains an unknown % of trans-R or perhaps none, they don't specify. 

 

https://megaresverat...ealth-benefits/

 

Remember, if the Supplement Facts label does not clearly indicate the amount (or percentage) of trans-resveratrol content, then there is no way of knowing the product purity content, or if it offers any health benefits.
 
A classic example is a “resveratrol” product sold on Amazon that claims to be “100% Pure Resveratrol – 1000 mg Per Serving – Max Strength,” at an extremely low price. Despite its “purity” claim, the “Supplement Facts” label does not indicate trans-resveratrol content, and thus, there is no way to know the actual purity of this product. Although the seller claims the product “has been third-party tested,” neither the testing certification nor a COA (Certificate of Analysis) is posted or available. The price is too good to be true.
 
Every Supplements Facts label should indicate both the “total product” content AND the “trans-resveratrol” content. By providing both values, we can calculate the actual purity of the product in question. For example, a 50% pure product should be indicated on the label as “Resveratrol (Polygonum Cuspidatum Root): 500 mg Yielding 250 mg Trans-Resveratrol.” Or, “Standardized to 50% Trans-Resveratrol.”

 

Are you recommending MegaResveratrol? Recently, David Sinclair spoke about RSV needing to be kept refrigerated, dry, and out of light to prevent degradation -- is that a real concern?



#16 Oakman

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Posted 30 November 2019 - 12:41 AM

^ not at all, don't know anything of them, except they have good advice about buying R. As for refrigeration, have to check that out.


Edited by Oakman, 30 November 2019 - 12:42 AM.


#17 brosci

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Posted 30 November 2019 - 03:02 AM

^ not at all, don't know anything of them, except they have good advice about buying R. As for refrigeration, have to check that out.

 

Fwiw, their story seems like they're trying to sell a decent product:

 

"Here is an enormous difference between our company and most other companies, and it’s not only found in the unmatched quality of the product. It’s in the story behind Mega Resveratrol and its beginning. In 2003, I was lucky enough to walk out of a hospital alive after surviving a heart attack, yet I felt like a helpless “walking time bomb.” I knew it wasn’t a question of if but when my next heart attack would happen. I thought I had two choices – I could rely on miracles or on doctors and statins. Unfortunately, neither prevented my first heart attack. For about a year, I searched for something better than statins or aspirin. I was looking for a natural product that would keep my blood flowing, regardless of my cholesterol levels, a product that would prevent further heart attacks. I tried different products, and in 2004, I found resveratrol—a natural anti-inflammatory and blood-thinner that would “work” perfectly with a cardiovascular disease I inherited from my father. The condition is known as Lipoprotein (a). It means I have a small LDL (bad) cholesterol particle size. These particles stick to each other, cause inflammation, clog the arteries and lead to heart attacks. About 70 million individuals in the United States suffer from LP(a). Since a particle size cannot be changed or treated, the only option is to keep the blood flowing by reducing inflammation and thinning the blood, which is what resveratrol does well. Back in 2003, the available purity of resveratrol was only 10%-20%. That meant that only 10%-20% of each capsule’s contents was the beneficial trans-resveratrol. The rest was filler and impurities. With such low purity levels, to achieve a dosage of 1000 mg of trans-resveratrol, I had to take 20, 30, or even 40 capsules a day (and deal with the gastrointestinal side effects of low purity resveratrol). Even today in 2018, most resveratrol sold in the market is of low purity (20%-50%). As you can imagine, I wanted a highly pure resveratrol product. With my business background, I knew I could produce it. In 2007, we started offering pure trans-resveratrol capsules. I founded Mega Resveratrol because I couldn’t resist offering a high-quality product that can prevent thousands of heart attacks and strokes. Mega Resveratrol is nothing less than what I would take myself."

 

I don't quite buy RSV as a way to statistically improve cardiovascular disease risk by some huge margin, but this company does seem to have an interest in not selling poor quality supplements.


Edited by brosci, 30 November 2019 - 03:05 AM.


#18 StevenL

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Posted 10 December 2019 - 03:31 AM

Interestingly, while I am very aware of Dr. Sinclair and follow what he says and does,  I got into Resveratrol initially years ago as part of a Lyme disease protocol from a highly scientific (as well as intuitive) Herbalist, Stephen Buhner.   Buhner likes to recommend the whole (or powdered but not refined)  plant root of Japanese Knotweed.   He feels that thealing plants carry a set of molecules acting in synergy and which may counterbalance undesirable effects.  So extracting Trans-resveratrol alone - just because it's the isolate that has been tested-  is to lose the full and safest effects of the rest of the molecules left behind in processing.

 

I have been taking TransR supplements myself most recently but looking over his recommendation again, I don't know what to think.  I am now considering just buying powdered knotweed as he recommends.  It will tend to be 50% transresveratrol.   So if you want 1000 mg of that, you need 2000 of knotweed.   Another issue.  I would probably just go with maybe 1200 mg knotweed and figure I'm getting at least 600 mg of the main ingredient plus supposed synergistic factor.   

 

Interesting ideas from an alternative world: http://buhnerhealing...ns-resveratrol/

http://lymeaware.fre...sage/index.html

 

No opinion, just throwing out some data points!    

 

Ah, and would the Trans-R in unrefined Knotweed be more stable?   Thus easier to be sure you are not taking a refined powder that has actually lost potency in comparison to the unrefined?



#19 Oakman

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Posted 10 December 2019 - 03:21 PM

There's a lot of controversy around whole herb vs standardized herbs vs pure extracts with herbal supplements. It seems to me that studies are mostly done with extract because you want to eliminate variables, and whole herbs/standardized herbs contain a plethora of compounds and so render scientific results moot or at least very ambiguous. 

 

I can see the reasoning of both sides of the argument. And the traditionalist are adamant that the whole herbs are the way to go as they have proven themselves over time. Pure extracts results give definitive results, and as far as those results they go, this is good. But would the results be better or worse using an alternative form? That's typically not part of a study's protocol, unfortunately. And if it was different, what caused the difference? That would be hard to determine, because it might be synergy of compounds including an extract or entirely a result of a different compound(s).

 

I find myself going around this logistic circle again and again with no real answers, even with passionate arguments from both sides. Personally, I don't 100% believe what I read, and certainly not articles on the internet. But in a world of limited answers, searching for n=1 results myself through experimentation, while imperfect and flawed scientifically, is often illuminating. Just try the available options for yourself. 


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#20 StevenL

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Posted 10 December 2019 - 04:30 PM

... in a world of limited answers, searching for n=1 results myself through experimentation, while imperfect and flawed scientifically, is often illuminating. Just try the available options for yourself. 

 

Yep.  Wisely stated.  I'm probably gonna decide based on convenience for living/traveling etc,  perhaps alternating a year of 100% Trans and then a year of knotweed.   

 

I was doing the cheaper one like that probably are just capsuled Knotweed (50% Trans is a good clue) but then moved to Dr. Best pure 600 mg.  Expensive though.   https://www.amazon.c...e?ie=UTF8&psc=1

 

Probably go with bulk though.  100% Trans or knotweed complete...hmmm



#21 NaHanyate

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Posted 05 January 2020 - 03:24 AM

Hello everybody,

I have a question. I recently started taking resveratrol (brand Mega Resveratrol). But I am getting an upset stomach almost immediately. Three to four trips to the bathroom, the first one within fifteen minutes.
Anyone else have this problem?

#22 aaaaaaal

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Posted 28 January 2020 - 12:06 PM

Hello everybody,

I have a question. I recently started taking resveratrol (brand Mega Resveratrol). But I am getting an upset stomach almost immediately. Three to four trips to the bathroom, the first one within fifteen minutes.
Anyone else have this problem?

 

I think it's normal for that to happen in the first few days.



#23 Gal220

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Posted 26 August 2020 - 01:56 PM

Revgenetics has a micronized product at a decent price, IF you buy 3 ! 

 

I would be interested in your sugar anylsis if you try it, must be nice having a solid way of verifying its effectiveness..



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#24 zorba990

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Posted 26 August 2020 - 03:06 PM

Megaresveratrol has a micronized version that works well for me.





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