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Why not to bother with 23andme/Ancestry limited DNA tests

23andme dna test wgs wes dantelabs

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#1 world33

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Posted 20 November 2018 - 11:42 AM


I initially posted this in a Facebook post and I think it is worth to re-post it here in Longecity for the community benefit.
 
I recently analyzed my 23andme raw data with the Enlis Genome Personal Tool and discovered the sad truth about how limited is the 23andme genetic test.
 
Basically the 23andme genetic test represents only:
1) the 0.031% of the full genome
2) the 0.078% of the full exome 
3) the 0.111% of the protein coding genome (a sub-segment of the exome).
[See attached screenshot]
Considering you can now buy a full genome sequencing test for $499 (currently on special for 199$ on black friday week) from Dantelabs (worldwide shipping) or Genos.co (US only) what is the point to bother with 23andme.com or ancestry.com genetic tests if your goal is to find out significant diagnostic information?!
Considering that what counts for diagnostic purposes is the protein coding of the genome, 23andme.com is able to provide me with only 0.111% of that data let alone who knows how reliable and accurate is their variant calling for that extremely limited genome sample.
On the subject of DTC DNA tests accuracy ...
 
"Analysis Questions Accuracy of Direct-To-Consumer Genetic Test Results
 
Quote: " About 40 percent of variants reported in raw data from direct-to-consumer genetic tests may be wrong, according to a new analysis"
 
If that is true, and not just scaremongering spread by other DNA testing services looking for business, that means that about 40% of the 0.111% of the protein coding genome taken into consideration by direct-to-consumers (DTC) genetic tests like 23andme.com could be inaccurate and/or give false positives. Again, If that is true, why even bother with DTC genetic tests and their interpretation.
 
It also arises the question on how accurate and comprehensive tools devoted to decode/interpret that extremely limited sample, including selfdecode, could they be for diagnostic purposes.
If anyone knows other software or tools that are able to analyze whole genome sequencing (WGS) or whole exome sequencing (WES) raw data (not just 23andme) in addition to the Enlis Genome Personal or Promethease I would appreciate if you could please share it here.

Attached Files


Edited by world33, 20 November 2018 - 11:43 AM.

  • Informative x 3
  • Agree x 2

#2 chrisv

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Posted 06 September 2019 - 05:31 PM

I would do Veritas

https://www.cnbc.com...f-your-dna.html

If $600 is too much wait for the price to come down. They report on the full genome (all 4 million+ SNPs.)



Click HERE to rent this GENETICS advertising spot to support LongeCity (this will replace the google ad above).

#3 aribadabar

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Posted 04 October 2019 - 03:35 AM

Have you checked this out? https://dna.land/



#4 kurdishfella

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Posted 23 January 2022 - 12:18 AM

Theres one use of it ive found which is : I have an idea really smart people should do the 23andme and ancestry test and find their 'lost' blood related 'family' and start a company in tech, science etc. As smart people usually have smart families so those blood cousins are more likely to be smart as well.

Edited by kurdishfella, 23 January 2022 - 12:20 AM.


Click HERE to rent this GENETICS advertising spot to support LongeCity (this will replace the google ad above).

#5 Mind

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Posted 07 February 2024 - 09:55 PM

Another reason to be cautious with your selection of DNA testing services - you never know who will end up owning your genetic data. After all the hype of how 23andMe was going to revolutionize medicine, it is now bankrupt and who knows where all the data will end up.







Also tagged with one or more of these keywords: 23andme, dna, test, wgs, wes, dantelabs

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