PUBLIC RELEASE:
20-FEB-2019 Young bone marrow rejuvenates aging mouse brains, study findsTransplanting marrow from young lab mice to old mice preserves memory and learning skills
CEDARS-SINAI MEDICAL CENTER
IMAGE: MICROGLIA IN BRAINS OF OLD MICE HAVE LARGER CELL BODIES WITH FEWER AND SHORTER BRANCHES THAN THOSE IN YOUNG MICE. BUT MICROGLIA OF OLD MICE WHO RECEIVED BONE MARROW TRANSPLANTS... view more
CREDIT: CEDARS-SINAI / COMMUNICATIONS BIOLOGY
LOS ANGELES (EMBARGOED UNTIL 5:00 A.M. EST ON FEB. 20, 2019) -- A new study has found that transplanting the bone marrow of young laboratory mice into old mice prevented cognitive decline in the old mice, preserving their memory and learning abilities. The findings support an emerging model that attributes cognitive decline, in part, to aging of blood cells, which are produced in bone marrow.
"While prior studies have shown that introducing blood from young mice can reverse cognitive decline in old mice, it is not well understood how this happens," said Helen Goodridge, PhD, associate professor of Medicine and Biomedical Sciences at Cedars-Sinai and co-senior author of the study. "Our research suggests one answer lies in specific properties of youthful blood cells."
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