World J Biol Psychiatry. 2017 Feb;18(1):54-62.
#1
Posted 14 March 2020 - 06:49 AM
#2
Posted 13 April 2020 - 04:35 AM
The mean dose is not reported here for individuals with BD (bipolar disorder). It can be rather high (link).
Usual Adult Dose for Mania Acute Control: 1800 mg/day
-Regular release formulations: 600 mg orally 2 to 3 times a day
-Extended release formulations: 900 mg orally 2 times a day
Long-term Control: 900 to 1200 mg/day
-Regular release formulations: 300 to 600 mg orally 2 to 3 times a day
-Extended release formulations: 600 mg orally 2 times a day
#3
Posted 14 April 2020 - 12:37 PM
The depletion may be the result of long-term overstimulation of asymmetric division, as it is known from previous work that lithium stimulates SCs.
sponsored ad
#4
Posted 15 April 2020 - 07:11 AM
The depletion may be the result of long-term overstimulation of asymmetric division, as it is known from previous work that lithium stimulates SCs.
According to my reading of the abstract, BD patients without lithium treatment actually had more VSELs than non-BD controls and this increased with disease duration. Lithium reduced numbers back to normal. So perhaps there is something about the damage done by BD that is stimulating VSEL release. Lithium may just be restoring homeostasis.
#5
Posted 15 April 2020 - 09:53 AM
The paper actually admits to both possibilities--
The second finding of the study is that the number of CD34+ VSELs, CD34+ HSCs,MSCs and EPCs was at similar levels in the lithium-treated patients to those in the controlsubjects. In the lithium-treated patients, the number of VSELs inversely correlated with theduration of lithium treatment and serum lithium concentration. In the light of the increasingnumber of these cells circulating in the PB of BD patients not receiving lithium, thisobservation may suggest that long-term treatment with lithium may result in a normalizationof the number of these cells in PB to the levels observed in healthy control subjects. It mightalso be a result of time- and/ or age-related depletion of these cells as a result of the lithiumtreatment.
#6
Posted 21 April 2020 - 07:32 AM
How do you detect a VSEL, anyway? CD34+ and CD133+ surface markers, both mentioned in the study, are not unique to VSELs.
I assume you select the right markers and then filter by size? I couldn't find an explanation in the study.
Also tagged with one or more of these keywords: lithuum, stem cells
Science & Health →
AgingResearch →
William Shatner and stem cell therapyStarted by osris , 08 Jan 2024 stem cells |
|
|
||
Science & Health →
AgingResearch →
Aging Theories →
The (new) telomere theory of agingStarted by hplus , 29 Apr 2023 telomeres, senescent cells and 1 more... |
|
|
||
Science & Health →
Supplements →
C60Oil →
What to make of C60 fullerenes in olive oil for life extension?Started by QuestforLife , 17 Oct 2022 c60, fullerene, oil oil, keto and 2 more... |
|
|
||
Community →
LongeCity →
Projects →
Seeking advice, validation, collaboration with exp lab techStarted by Uncle Frank , 29 May 2021 connect, experiment, collaborate and 2 more... |
|
|
||
Science & Health →
Medicine & Diseases →
Stem Cells →
Pericytes as adult stem cellsStarted by timedilation , 12 Jan 2021 stem cells |
|
|
1 user(s) are reading this topic
0 members, 1 guests, 0 anonymous users