How do you take it?
What's your dosage?
What brand do you use?
Posted 29 September 2021 - 12:43 AM
How do you take it?
What's your dosage?
What brand do you use?
Posted 29 September 2021 - 05:47 PM
Posted 29 September 2021 - 10:15 PM
I am not using NMN. I use liposomal quercetin, it lowers CD38, and thus saves NAD +. I don't need to level it up much at the moment. I'm 39 years old.
I'm 39 also. Is that the standard consensus here for people our age? To use liposomal quercetin?
Posted 30 September 2021 - 12:10 PM
Neither NMN nor senolytics increase life in long-lived mouse models more than diet.
I use liposomal quercetin to improve my quality of life a little.
Edited by Kentavr, 30 September 2021 - 12:14 PM.
Posted 30 September 2021 - 12:23 PM
Posted 30 September 2021 - 05:13 PM
If I want to help my whole body, I need to take either NMN in liposome form or a higher dosage, which is expensive.In addition, NMN does not cross the blood-brain barrier, and for this reason, you still have to take NAD + (NAD + crosses the blood-brain barrier).I'm saving.
with a molecular weight of 663 I doubt NAD is crossing the BBB, do you have a source for that claim?
NAM has a Molecular weight of 122 and readily crosses the BBB. As most of us know, a m. weight below 500 is considered necessary for crossing the BBB
Posted 30 September 2021 - 05:22 PM
with a molecular weight of 663 I doubt NAD is crossing the BBB, do you have a source for that claim?
NAM has a Molecular weight of 122 and readily crosses the BBB. As most of us know, a m. weight below 500 is considered necessary for crossing the BBB
Yes, I have proof:
https://alivebyscien...-brain-barrier/
https://alivebyscien...-cell-membrane/
Posted 30 September 2021 - 05:26 PM
Those are mice studies. They may or may not apply to humans. Its proof of nothing, unfortunately.
Posted 30 September 2021 - 05:35 PM
Those are mice studies. They may or may not apply to humans. Its proof of nothing, unfortunately.
However, it does not refute either. Do you have more reliable evidence?
Posted 30 September 2021 - 06:30 PM
actually you made the claim so burden of proof is on you
I mean NAD+ may cross the BBB, but I need more evidence than mice studies
Posted 30 September 2021 - 07:10 PM
actually you made the claim so burden of proof is on you
I mean NAD+ may cross the BBB, but I need more evidence than mice studies
I have no direct evidence that NAD + crosses the human blood-brain barrier.
Bruzzone et al. (21) have shown that connexin 43 (Cx43) channels are permeable to extracellular NAD
Сonnexin 43 is also available in humans: https://en.wikipedia.org/wiki/GJA1
Therefore, it is very likely that the mechanism of action is the same.
Consider this study as an example:
https://pubmed.ncbi....h.gov/29366904/
Posted 03 October 2021 - 02:57 AM
Both of these studies are for injected NAD+.
Posted 03 October 2021 - 07:20 PM
An additional benefit of inhibiting CD38 is this: if I suddenly stop taking liposomal quercetin, the CD38 count will not rise quickly. This gives me a "safety margin" in case of unforeseen circumstances.This is the second reason why at 39 I use liposomal quercetin and not NMN.
Liposomal Quercetin for lowering inflammation does make sense to me. I didn't realize it also inhibits CD38. Maybe not as much as Apigenin though?
Alivebyscience posted an article comparing them, fisetin and others.
https://alivebyscience.com/lower-inflammation-to-increase-nad/
Almost seems like they are saying take some of these anti-inflammatories to decrease NAD+ consumption and you don't need to take NMN or NR - is that what you are thinking Kentavr?
Posted 04 October 2021 - 06:27 AM
Both of these studies are for injected NAD+.
Here we consider the possibility of NAD + crossing the blood-brain barrier. In this context, it is not particularly important how the supplement entered the bloodstream.
Liposomal Quercetin for lowering inflammation does make sense to me. I didn't realize it also inhibits CD38. Maybe not as much as Apigenin though?
Alivebyscience posted an article comparing them, fisetin and others.
https://alivebyscience.com/lower-inflammation-to-increase-nad/
Almost seems like they are saying take some of these anti-inflammatories to decrease NAD+ consumption and you don't need to take NMN or NR - is that what you are thinking Kentavr?
Posted 10 October 2021 - 02:52 AM
But, since my quercetin is in liposomes, and apigenin is still too expensive, it is much more profitable for me to take liposomal quercetin.
I agree it does seem things like quercetin and apigenin to fight inflammation make a lot of sense, which is what ABS is saying.
I see they have a liposomal apigenin now, which isn't expensive imo.
Edited by able, 10 October 2021 - 02:58 AM.
Posted 15 October 2021 - 11:48 PM
Instead of expensive supplements, consider dried parsley - a very rough figure of 45mg of Apigenin can be found per g. A heaped teaspoon of this with lunch is a cheap and convenient way to increase. I never actually weigh it, however dump in a heaped teaspoon which comes to around 1.6g of dried parsley.
https://www.ncbi.nlm...les/PMC5791748/
I also use LEX triple action cruciferous morning and night for a bit of extra apigenin and DIM/I3C which should be handy for cancer prevention.
I understand Luteolin should be a superior CD38 inhibitor, however definitely a bit harder to come across, and not particularly bio available.
Posted 03 November 2021 - 04:47 AM
Edited by Paravani, 03 November 2021 - 04:50 AM.
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