Do you have any sources for this? Also, that is useful information, but telomere/telomerase therapies will only get you so far. Telomere length is not the only factor in the age (and epigenetic age) of a cell, and afaik you can't just keep increasing it to divide endlessly. Out of curiosity, how have telomerase therapies fared at "prolonging the life of long-lived mice"?
I never said the Stem Cell Expansion Protocol was a "senolytic protocol." I said Turnbuckle had a stem cell/age reversal protocol with a senolytic component to it, and that the combination of stem cell rejuvenation and senolytics is a promising avenue of life extension. Even if you think the stem cell part is much more useful (which I would agree with), the senolytics are still playing an important role.
I appreciate this discussion, but I should say that you probably are not going to convince me that the original question isn't worth answering.
Your message definitely deserves a reply.
However, I want to tell you about several ways that may help your cardiovascular system without using senolytics.
Method 1:
It was recently discovered that senescent cells of the immune system are potentially some of the most damaging of all senescent cells, as they spread tissue damage and rapid aging to other organs and systems in the body:
Further:
an increase in SASP
an increase in CD38 on macrophages M1
degradation of NAD +,
a decrease in SIRT 1-7 activity,
acceleration of telomere shortening due to a decrease in SIRT 1 activity (namely, the RATE OF SHORTING OF telomeres correlates with mortality, not their length),
etc.
Now it becomes clear to me why people who have completed several courses of epitalon become outwardly younger over time. Apparently, Epitalon activates the immune system, which returns to a younger state. Perhaps it stops harming the body and again removes only aging cells from the body.
I believe that this is the more correct way, since a correctly functioning immune system removes only aging cells without affecting healthy ones. Additionally, a healthier immune system can better protect against cancer, which is also a definite plus.
After this news, many scientists are probably shocked. Because this is a more correct way to destroy aging cells.
I take the drug Endoluten, which, according to the manufacturer of the drug, has an efficiency of about 80% of the effectiveness of an injection of Epitalon. I have no evidence for this statement, but the drug is really powerful, I can feel it.
My wife says that in appearance I look 34 years old, although I am 39 years old (everything can change for the worse even tomorrow, I'm talking about the impression of my wife as of today).
Method 2:
You Can Take Coenzyme Q10 + Selenium:
https://www.nutraing...rsist-for-years
And for this it is not necessary to remove senescent cells. Which coenzyme to choose so that it works, I wrote in this thread (so that later it would not be excruciatingly painful from the thought that you wasted money):
https://www.longecit...mn-in-20212022/
This thread also explains why I am not currently using NMN.
Method 3:
Reduce the thickness of intimate media (taking statins + sartans + diet + exercise):
https://nestarenie.r...st-sosudov.html
https://nestarenie.r...tima-media.html
https://nestarenie.r...yi-molozhe.html
Method 4:
Turnbucle Mitochondrial Dynamics Protocol (especially its February 17, 2021 protocol):
https://www.longecit...ndpost&p=903440
Method 5:
You can increase NAD + with liposomal quercetin, which will also improve endothelial function without resorting to senolytics. Quercetin alone will not be able to kill senescent cells, as it needs help in the form of dasatinib. I wrote from this thread:
https://www.longecit...mn-in-20212022/
Etc. There are many of these ways, and it is not necessary to take such risky means as senolytics.
Edited by Kentavr, 05 October 2021 - 08:43 AM.