GABA-a Receptor Damage and Repair

Stole this from ScienceGuy's "TREATING ANXIETY SAFELY & EFFECTIVELY" thread: http://www.longecity...ly-effectively/

BACOPA MONNIERI:

BACOPA MONNIERI in fact might prove very helpful, since this has been shown in studies firstly to NOT be a GABA RECEPTOR AGONIST, but has in fact be shown to upregulate down-regulated GABA receptors, which means it could prove highly useful in helping to treat recovery from GABA RECEPTOR AGONIST ADDICTION:

Epilepsy Behav. 2010 Apr;17(4):441-7. Epub 2010 Feb 11.

Behavioral deficit and decreased GABA receptor functional regulation in the cerebellum of epileptic rats: effect of Bacopa monnieri and bacoside A.

Mathew J, Peeyush Kumar T, Khan RS, Paulose CS.

Source
Department of Biotechnology, Molecular Neurobiology and Cell Biology Unit, Centre for Neuroscience, Cochin University of Science and Technology, Kerala, India.

Abstract
In the present study, the effects of Bacopa monnieri and its active component, bacoside A, on motor deficit and alterations of GABA receptor functional regulation in the cerebellum of epileptic rats were investigated. Scatchard analysis of [(3)H]GABA and [(3)H]bicuculline in the cerebellum of epileptic rats revealed a significant decrease in B(max) compared with control. Real-time polymerase chain reaction amplification of GABA(A) receptor subunits-GABA(Aalpha1), GABA(Aalpha5,) and GABA(Adelta)-was downregulated (P<0.001) in the cerebellum of epileptic rats compared with control rats. Epileptic rats exhibit deficits in radial arm and Y-maze performance. Treatment with B. monnieri and bacoside A reversed these changes to near-control levels. Our results suggest that changes in GABAergic activity, motor learning, and memory deficit are induced by the occurrence of repetitive seizures. Treatment with B. monnieri and bacoside A prevents the occurrence of seizures thereby reducing the impairment of GABAergic activity, motor learning, and memory deficit.

PMID: 20153260

thanks for the quote, I'll check it out.

Bacopa upregulation of GABA receptors is definitely a very long process. Been already 2 weeks fully on bacopa (500mg/Himalaya) and still hasn't really acted on my GABA system knowing that latter was screwed up due to alcohol/GHB/phenibut use.

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How long gaba antagoinst will up-regulate gaba receptor and is it safe to take with alcohol ?

Maybe a GABA antagonist such as tiocolchicoside can help. At low doses (4 mg) for 1 week!

Maybe a GABA antagonist such as tiocolchicoside can help. At low doses (4 mg) for 1 week!

Do it cause more glutamate toxicity while treatment ? .

I take some antibiotic drug and have gaba antagonist effect ,result to damaged my brain after few dose of it .

so question is how to protect from glutamate while taking gaba antagonist drug ?

Edited by Nootropix, 23 April 2013 - 12:50 PM.

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dear sir,

Please make sure you get at least 9-10 hours of sleep each night.
Also you should reduce masterbation, if you try to stop masterbation for a total of [6] weeks. Also avoid all sugar foods (sweets) for [6] weeks. avoid caffeine I think also.

get the diet sleep and exercise into grouping it up

ok? so is it a DEAL?