I recently heard about a compounded nasal spray called Synapsin that contains the ginsenoside Rg3 (from ginseng) and nicotinamide riboside. The pharmacy I know of that compounds it also includes B-12.
Rg3 helps decrease neuronal inflammation. NR supports mitochondrial energy production.
They're saying the mix is good for conditions ranging from Alzheimer's to dementia, Parkinson's, fibromyalgia, PTSD, concussions, brain fog, adrenal insufficiency, and chronic fatigue. Apparently, chronic inflammatory diseases can also cause inflammation in the brain.
I'm wondering whether it might also help reverse cortical atrophy and what the long-term health and longevity implications might be, especially compared to taking NR alone (and therefore at a much higher dose).
I've tried Rg3 alone orally before, but never noticed much. I've been taking oral NR (Niacel) for many months now (dose recently increased to 500 mg twice a day), as well as oral and now injectable methyl B-12. A nasal spray should reach the brain more effectively, though.
One downside is cost. Here in NZ, it runs about US$225 for a 6 week supply (20cc). However, that puts it in the range of high-dose oral NR alone, so it might be a reasonable alternative.
I haven't found much on the web about it, but here's one link that might be of interest:
https://dcapharmacy....in-nasal-spray/