https://www.ncbi.nlm...les/PMC5694488/
Based on differential NAD+ utilization during glucose- vs. ketone body-based acetyl-CoA generation for entry into the tricarboxylic cycle, we propose that a KD will increase the NAD+/NADH ratio. When rats were fed ad libitum KD, significant increases in hippocampal NAD+/NADH ratio and blood ketone bodies were detected already at 2 days and remained elevated at 3 weeks, indicating an early and persistent metabolic shift. Based on diverse published literature and these initial data we suggest that increased NAD during ketolytic metabolism may be a primary mechanism behind the beneficial effects of this metabolic therapy in a variety of brain disorders and in promoting health and longevity.
https://www.ncbi.nlm...les/PMC6125375/
we established that the increase in ratio was solely due to an increase in the oxidized form of NAD (Figure Figure1B).
As shown in Figure Figure1C, a rapid, robust increase in sirtuins’ activity was detected at 2d of KD treatment compared to control, and remained elevated at 3w, albeit reduced.
Edited by HaplogroupW, 17 September 2018 - 05:31 AM.