• Log in with Facebook Log in with Twitter Log In with Google      Sign In    
  • Create Account
  LongeCity
              Advocacy & Research for Unlimited Lifespans

Photo
- - - - -

How to do Fisetin skin cream

fisetin skin cream

  • Please log in to reply
9 replies to this topic

#1 ryukenden

  • Guest
  • 232 posts
  • 19
  • Location:Uk
  • NO

Posted 10 October 2018 - 04:24 AM


I understand Fisetin goes through extensive hepatic metabolism.

I am thinking of how to make Fisetin skin cream as there are so many senescent cells in our skin,

What do you think of making a Fisetin skin cream? How to make such cream?
  • like x 1

#2 able

  • Guest
  • 851 posts
  • 406
  • Location:austin texas
  • NO

Posted 10 October 2018 - 06:57 AM

Stir it in some DMSO and roll on?

 

Worked well for me with NMN.  

 

Not a cream, but it likely would do the job of carrying it into the skin, which is what you are after, isn't it?


Edited by able, 10 October 2018 - 06:59 AM.


sponsored ad

  • Advert
Click HERE to rent this advertising spot for SUPPLEMENTS (in thread) to support LongeCity (this will replace the google ad above).

#3 ryukenden

  • Topic Starter
  • Guest
  • 232 posts
  • 19
  • Location:Uk
  • NO

Posted 11 October 2018 - 07:28 AM

Stir it in some DMSO and roll on?

Worked well for me with NMN.

Not a cream, but it likely would do the job of carrying it into the skin, which is what you are after, isn't it?


Thank you

#4 QuestforLife

  • Location:UK
  • NO

Posted 11 October 2018 - 12:23 PM

Very good idea!

 

There seems to be disagreement on exactly how soluble Fisetin is in DMSO; I've seen a range from 10-57mg/ml quoted. Nevertheless even at only 10mg/ml, you could dissolve a gram of fisetin in 100ml of DMSO.

 

Of course it might just go straight into the blood stream rather than remain in the skin for long enough to exert it's effects there. But either way you'd have avoided liver first pass metabolism. If you wanted to specifically hit the senescent cells in the skin maybe you'd need to reapply this multiple times a day to make sure the dermis is getting the benefit.



#5 ryukenden

  • Topic Starter
  • Guest
  • 232 posts
  • 19
  • Location:Uk
  • NO

Posted 15 October 2018 - 02:12 PM

Very good idea!

There seems to be disagreement on exactly how soluble Fisetin is in DMSO; I've seen a range from 10-57mg/ml quoted. Nevertheless even at only 10mg/ml, you could dissolve a gram of fisetin in 100ml of DMSO.

Of course it might just go straight into the blood stream rather than remain in the skin for long enough to exert it's effects there. But either way you'd have avoided liver first pass metabolism. If you wanted to specifically hit the senescent cells in the skin maybe you'd need to reapply this multiple times a day to make sure the dermis is getting the benefit.

Thank you. I have ordered both Fisetin and DSMO and will try to dissolve 1 gram in 100 ml.

#6 XRT doc

  • Guest
  • 15 posts
  • 5
  • Location:miami usa

Posted 15 October 2018 - 03:06 PM

Does anyone know if it would better to use dmso liquid vs gel. Also, can adding edta increase absorption?


Edited by XRT doc, 15 October 2018 - 03:06 PM.


#7 ryukenden

  • Topic Starter
  • Guest
  • 232 posts
  • 19
  • Location:Uk
  • NO

Posted 15 November 2018 - 09:42 PM

I found the following study using topical Fisetin on mice.

https://www.ncbi.nlm...00/#!po=23.2143

#8 Daniel Cooper

  • Member, Moderator
  • 2,634 posts
  • 631
  • Location:USA

Posted 15 November 2018 - 09:56 PM

I found the following study using topical Fisetin on mice.

https://www.ncbi.nlm...00/#!po=23.2143

 

 

In that study they used polyethylene glycol (PEG) 400 as the vehicle.  I think I'd use that instead of DMSO since we have no test data on that combination.


  • Enjoying the show x 1

#9 ambivalent

  • Guest
  • 744 posts
  • 167
  • Location:uk
  • NO

Posted 16 November 2018 - 04:51 PM

Anyone know of the excipient in Swanson's Fisetin and associated risk-profile?



sponsored ad

  • Advert
Click HERE to rent this advertising spot for SUPPLEMENTS (in thread) to support LongeCity (this will replace the google ad above).

#10 ryukenden

  • Topic Starter
  • Guest
  • 232 posts
  • 19
  • Location:Uk
  • NO

Posted 16 November 2018 - 05:03 PM

In that study they used polyethylene glycol (PEG) 400 as the vehicle. I think I'd use that instead of DMSO since we have no test data on that combination.


Good point, thank you.




1 user(s) are reading this topic

0 members, 1 guests, 0 anonymous users