https://www.scienced...924977X16320120
These subtle effects were found at a 1:1 CBD:THC dose ratio but were not accentuated by a 5:1 dose ratio. CBD did not alter the trajectory of enduring THC-induced anxiety nor tolerance to the pharmacological effects of THC. There was no evidence of CBD potentiating the behavioural effects of THC. However we demonstrated for the first time that repeated co-administration of CBD and THC increased histone 3 acetylation (H3K9/14ac) in the VTA and ΔFosB expression in the nucleus accumbens. These changes suggest that while CBD may have protective effects acutely, its long-term molecular actions on the brain are more complex and may be supradditive.
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"We thus hypothesized that the administration of HAT (histone acetyltransferase) inhibitors could
be beneficial for MDS/AML pa- tients with reduced Gfi1 expression as it could reverse the
increased acetylation of H3K9. Curcumin is a HAT inhibitor which is used as a spice "
https://www.exphem.o...0439-9/abstract