I'm surprised overmineralization & Ferrotoxic Disease doesn't get more attention. The evidence is compelling, and certainly is piling up. I've got a collection on this here:
https://www.longecit...isease-omnibus/
Bill Sardi's thesis on: "A Unifying Theory of Aging" has a lot of interesting angles on overmineralization.
It would be very hard to argue any condition (overmineralization) that promotes high level hydroxyl radical formation might not be something we all want to avoid.
What I like most about practicing iron homeostasis for longevity is that it is so easy to do, and there really is no downside provided you don't get carried away and become briefly anemic.
Blood donation is remarkably save and effective, & Curcumin, Quercetin & IP6 are all quite benign chelators.
More isn't always better, but if you can remember this caution, it difficult to imagine how tweaking transition metals (iron & copper) lower as we age would not provide a substantial benefit; no Spartan diets, calorie restricting, or grueling exercise required. It's been my fountain of youth for over 30 years (donated over six gallons of blood).
Edited by Dorian Grey, 22 February 2019 - 02:46 AM.