Hi, I'd like to know about the desirability of autophagy versus apoptosis. Which is more desirable - and under what conditions and why? What are the pro's and cons of each?
Autophagy seems to be about rebooting and recycling malfunctioning cells, while apoptosis is about killing off malfunctioning cells (and letting fresh ones take their place).
A senolytic would cause apoptosis - is there a counterpart word for a substance which causes autophagy?
Since apoptosis typically triggers replacement by adjacent neighboring cells, then those new daughter cells would have slightly shorted telomeres compared to the pre-apoptosis situation.
Meanwhile, autophagy would not result in any telomere shortening - or would it?
Autophagy is less drastic than apoptosis-&-replacement, but so can it therefore result in a defective cell not being fully cured?
Edited by manofsan, 16 March 2019 - 02:00 AM.