• Log in with Facebook Log in with Twitter Log In with Google      Sign In    
  • Create Account
  LongeCity
              Advocacy & Research for Unlimited Lifespans

Photo
* * * * * 1 votes

Interim Results for Epitalon Study

epitalon

  • Please log in to reply
5 replies to this topic

#1 VP.

  • Guest
  • 498 posts
  • 200

Posted 25 March 2019 - 06:54 PM


Not ready for prime time.

We have intermediate results for the first 6 months of our epitalon mouse lifespan study, which we're presenting here. (Big thanks to our partners Ichor Therapeutics for making this possible.)

While the study is not complete, there does appear to be a difference between the treatment and control groups regarding lifespan thus far, as well as some of the other metrics of motor function.

Since this study is investigator-blinded, the two treatment arms are labeled Lifespan A and Lifespan B. However, the longer-lived lifespan arm (Lifespan B) is comparable to, not superior to, historical survival data for C57BL/6 mice, while the shorter-liived arm (Lifespan B) is shorter than historical survival data, which means that there's reason to be concerned that epitalon shortens, rather than lengthening, lifespan. Moreover, Lifespan B appears to be superior or equal to Lifespan A in all motor tests, so far, which is consistent with the hypothesis that the Lifespan A condition is non-beneficial.

However, this is still a highly preliminary guess.  More than 70% of the mice in both groups are still alive; the identity of each group is still blinded; and thus we'll have to wait for the completion of the study to get conclusive answers.

https://thelri.org/b...epitalon-study/


  • Informative x 5

#2 pone11

  • Guest
  • 654 posts
  • 157
  • Location:Western US
  • NO

Posted 16 November 2019 - 11:17 PM

Can you update us on the mortality data for Lifespan A and B in this preliminary study?



sponsored ad

  • Advert
Click HERE to rent this advertising spot for SUPPLEMENTS (in thread) to support LongeCity (this will replace the google ad above).

#3 Tom Andre F. (ex shinobi)

  • Guest
  • 423 posts
  • 111
  • Location:France

Posted 18 November 2019 - 12:07 AM

sorry but what about the control group ? its not clear or I miss something here



#4 male_1978

  • Guest
  • 109 posts
  • 29

Posted 18 November 2019 - 10:22 AM

sorry but what about the control group ? its not clear or I miss something here

 

The point is that the study is double-blind. We do not know whether the control group is Group A or Group B. 

 

Only thing we know is, that that one group performs similar and one performs worse than what was expected for normal mice.

 

So the wild speculation with preliminary data is that the group which performs "normal" is the placebo group and the group which performs "worse" is the threated group.



#5 ortcloud

  • Guest
  • 329 posts
  • -1
  • Location:in the oortcloud Member 2007

Posted 03 December 2019 - 08:01 PM

@VP.

 

Where can we find the dose amounts and schedule for the mouse study?



sponsored ad

  • Advert
Click HERE to rent this advertising spot for SUPPLEMENTS (in thread) to support LongeCity (this will replace the google ad above).

#6 VP.

  • Topic Starter
  • Guest
  • 498 posts
  • 200

Posted 04 December 2019 - 04:10 PM

https://thelri.org/b...epitalon-study/

We now have 12-month data on our first mouse lifespan experiment, on the pineal-derived peptide Epitalon.  As always, we've uploaded the files to the experiment's OSF project.  Big thanks to our partners at Ichor Therapeutics!

As you can see, we've reached the 50% survival point, and there's no significant difference between the treatment and control groups (which are still labeled A and B; since this is a blinded experiment, we don't know which is which.)

Of course, there could still be an effect on maximal lifespan; we'll have to wait and see if the compound makes a difference there.

In terms of motor performance (a battery of tests for the mice's strength and endurance, which decline with age in mice as well as humans) we see no significant difference on the latest measurements in three out of four tests; the horizontal bar test (which measures coordination) continued to show significantly better mean performance for Group B than Group A.

 

1567714544-screen-shot-2019-09-05-at-1-0
1567714580-screen-shot-2019-09-05-at-1-0
1567714594-screen-shot-2019-09-05-at-1-0
1567714619-screen-shot-2019-09-05-at-1-0






Also tagged with one or more of these keywords: epitalon

1 user(s) are reading this topic

0 members, 1 guests, 0 anonymous users