More on direct NAD+ IV being convenient or not yet given the NAD+ testing level reached so far, alternatives such as niacin and some others.
Edited by Engadin, 22 April 2019 - 01:12 PM.
Posted 22 April 2019 - 01:10 PM
More on direct NAD+ IV being convenient or not yet given the NAD+ testing level reached so far, alternatives such as niacin and some others.
Edited by Engadin, 22 April 2019 - 01:12 PM.
Posted 22 April 2019 - 07:41 PM
A good cautionary video. His main point is that we don't know enough about NAD+ signalling outside the cell in order to be injecting it. He argues that the safer way to increase NAD+ (right now) is through oral supplements.
Posted 23 April 2019 - 11:23 AM
A good cautionary video. His main point is that we don't know enough about NAD+ signalling outside the cell in order to be injecting it. He argues that the safer way to increase NAD+ (right now) is through oral supplements.
Yep, and at ABN they have post a quick response to Dr. Masterjohn vid:
Yes, Chris Masterjohn, increased NAD+ in the bloodstream IS a good thing.
This title might seem obvious to anyone who has spent an hour or more reading about NAD+ and what it means for our health.
We know that NAD+ levels fall as we age, which correlates with decreased health and increased disease.
The reason for taking NAD+ precursors such as NR or NMN is to restore NAD+ levels in cells throughout the body.
NAD+ not supplied to the blood by liver
In this short podcast, Dr Chris Masterjohn speaks as though blood levels of NAD+ are not important.
Dr Masterjohn relies upon the March 2018 research by Ling Lui that says NAD+ precursors such as NR or NMN do not reach the bloodstream.
They are metabolized in the liver, which excretes only Nicotinamide (NAM) to the bloodstream for other tissues to use in the salvage pathway to create the NAD+ they need.
It does seem that the main pathway for NAD+ creation outside the liver may be from NAM excreted from the liver.
What IS the main source of NAD+ in the blood?Dr Masterjohn is right that we don’t currently know the source of NAD+ in the blood.
He assumes the source is mostly from recycling of dead cells, and that increased NAD+ in the blood is not a normal pathway used by the body to distribute NAD+.
5:40 – He says the source of NAD + in blood are dead cells
Dr Masterjohn says he believes supplying the liver with NAD+ precursors and letting it “drip feed” NAM into the bloodstream is the safer, more natural method to help restore NAD levels and that supplying NAD+ directly to the bloodstream may be unsafe.
Dr Masterjohn agrees that:5:00. Dr Masterjohn agrees that NAD+ is clearly taken up by some cells
Where we think he is mistaken
This bias against increased NAD+ in the bloodstream does not explain why:
– NAD+ levels are less that 1/2 in old animals, and lower NAD+ correlate with poor health.
– Virtually every study using NR, NAM, NMN, or NAD+ oral supplements or injection that showed some health benefit also shows elevated levels of NAD+ in the bloodstream.
– Chromadex and Elysium Health tout the ability of their products to elevated blood NAD+ levels as a primary endpoint in their research to show effectiveness of their products
The research below very clearly show that NAD+ in the blood is definately used by the body.
Higher levels of NAD+ in mothers blood benefits nursing pupsPerhaps the strongest proof that the body does in fact utilize blood NAD+ levels to benefit other tissues is Dr Brenner’s latest research with nursing mice were he asserts that the sole mechanism for the greatly improved health of babies whose mothers received NR was the increased NAD+ in blood of the mothers.
This study fed lactating mice Nicotinamide Riboside (NR) in chow for 21 days after birth of offspring to measure the effect on the health of their pups who did not receive any NR.
After 21 days, the pups were removed from the mothers and fed normal chow.
Surprisingly, the offspring whose mothers received NR exhibited:
These improvements in health and behavior persisted for the length of the study, which was 90 days after birth.
Researchers found NR was not present in the bloodstream or mothers milk.
Dr Brenner says the increased NAD+ in bloodstream induced higher NAD+ in the milk, which was the sole reason for the benefit to the pups.
Nursing mother have lower levels of NAD+ in liver and higher levels in blood
Comparing Non-lactating and Lactating females without supplementation shows the nursing mothers sacrifice NAD+ from their liver to keep levels higher in the blood, making more NAD+ available for their pups.
Researchers don’t know the mechanism for HOW this happens, but that clearly demonstrates that increased levels of NAD+ is beneficial.
When given NR, nursing mother have higher levels of NAD+ in liver and bloodComparing the blood NAD+ levels of lactating mothers, you clearly see that they are able to increase blood NAD+ levels even more with supplementation of NR. The result is higher NAD+ in the mothers milk, and healthier offspring from drinking this milk.
Increased levels of NAD+ IN THE BLOOD is useful.
We think this latest research by Dr Brenner clearly prove that:
Nursing mothers sacrifice their health temporarily to enable them to supply MORE NAD+ IN THE BLOOD.
Supplying NAD+ direct to the bloodstream should not be feared.
Source: https://alivebynatur...s-a-good-thing/
Science & Health →
Supplements →
Resveratrol →
Why Niacinamide Outshines ResveratrolStarted by osris , 23 Mar 2024 niacinamide, resveratrol, nad+ and 1 more... |
|
|
||
Science & Health →
Supplements →
NAD+ →
Best NMN/NAD+ cofactor?Started by Gal220 , 14 Mar 2024 cofactor, nad+, nucleotides |
|
|
||
Science & Health →
Supplements →
NAD+ →
Boosting NAD+ can fuel cancer - article. Is this scare-mongering?Started by osris , 07 Feb 2024 nad+, cance |
|
|
||
Science & Health →
Supplements →
NAD+ →
New Double Blind RCT - High D0se NR Supplementation Induces Potent Nad + Response and Improvement In Parkinson'sStarted by joesixpack , 02 Dec 2023 nad+ |
|
|
||
Science & Health →
Supplements →
NAD+ →
New Long Term Study - NR Improves Coordination and eye movementStarted by joesixpack , 20 Nov 2023 nad+ |
|
|
0 members, 1 guests, 0 anonymous users