Honestly, not a very helpful reply. I would say I'm obviously asking the question of whether, within the ranges of the extremely potent curcumin now available, what's going on, are we seeing higher levels of adverse responses or whatever. If you don't know, that's cool.
I don't think anyone here can give an informed answer to your question. There likely has been no testing of that formulation at that dose. And the "277x potency" claim is a near meaningless marketing statement that I can't really translate to any real dose of a curcumin that has actually been tested.
I think you're approaching the question from the wrong end. The approach should not be "is this arbitrarily high dose ok?" but rather, what evidence of an effective dose exists for whatever benefit you're trying to achieve.
So, what you should do is look at animal and human testing to see what doses they used (translating any animal studies to Human Equivalent Doses) that pertain to whatever benefit they were able to elicit.
You asked an ill defined question and I gave you an ill defined answer. If you'll look however at my second answer you'll see that I suggest you should try to pick a dose based on a clinical or animal study and that certainly if you're getting reproducible adverse reactions like diarrhea you should probably not continue with that dose (which I would think would be rather self obvious).