Why look at worms when we can look at people taking metformin vs those that don´t? Metformin seems to decrease mortality and morbidity in humans.
"In a November 2014 observational study published in Diabetes, Obesity and Metabolism, Christian A. Bannister, PhD, MSc, a data scientist with the Cochrane Institute of Primary Care and Public Health at Cardiff University, U.K., studied the progression to all-cause mortality among 78,241 patients with type 2 diabetes treated with metformin, 12,222 treated with sulfonylureas and 90,463 controls without diabetes, using data from the U.K. Clinical Practice Research Datalink.
Researchers found that patients treated with metformin monotherapy had longer survival vs. matched controls without diabetes (unadjusted mortality rates of 14.4 and 15.2, respectively, per 1,000 person-years), whereas those treated with sulfonylureas had reduced survival vs. matched controls (unadjusted mortality rates of 50.9 and 28.7 deaths per 1,000 person-years, respectively).
“This supports the position of metformin as first-line therapy and implies that metformin may confer benefit in nondiabetes,” the researchers wrote."
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