A just released study on the effects of metformin on aged populations:
Late life metformin treatment limits cell survival and shortens lifespan by triggering an aging-associated failure of energy metabolism
A free full link to the study: https://www.biorxiv....1/863357v1.full
Summary
Stabilization of cellular ATP levels alleviates late life metformin toxicity in vitro and in vivo.
Late life metformin treatment limits cell survival and shortens lifespan.
Metformin exacerbates aging-associated mitochondrial dysfunction causing fatal ATP exhaustion.
Old cells fail to upregulate glycolysis as a compensatory response to metformin.
The dietary restriction (DR) mimetic response to metformin is abrogated in old animals.
PKA and not AMPK pathway instigates the early life DR response to metformin.
Except
Degradation of fatal ATP exhaustion may be counteracted by simultaneous use of rapamycin.