https://www.frontier...2020.00354/full
"It has been previously reported that selective removal of senescent cells was sufficient to maintain trabecular bone mass in aged mice (Farr et al., 2017). Surprisingly, 2 weeks of in vivo administration of navitoclax did not improve, and instead significantly decreased trabecular bone volume fraction in aged female and male mice (−60.1% females, −45.6% males)....."