I'd like to share my perspective on COVID-19 management after spending countless hours researching. Part of the problem is many are looking for that silver bullet. But a number of leading treatments have failed in providing the desired results [1], which leads me to believe much of the recovery comes down to our own immune function and reducing the inflammatory immune response which follows. Also vaccines ... several are on pause as vaccine researchers investigate adverse reactions observed in their clinical trials. Evaluating individual treatments is helpful, however important to note that COVID-19 is a complex disease that must be met with an equally sophisticated treatment plan. Such a plan needs to be laid out with absolute clarity among the science and medical communities. I feel the optimal situation is treating in the most proactive, natural way possible while aiming to minimize side effects from the virus, the treatments, and avoiding the long hauler symptoms which may arise. The situation gets a lot more dire in the moderate to severe cases, so researching treatments with a focus on those stages is not where we as biohackers want to invest as much of our time if we're looking to beat this virus in a meaningful way. Surely, if you're in that position, get to a hospital right away!
One of the most comprehensive treatment plans out there is MATH+. [2] It promotes a phased approach which is important, and so I take some elements from it. There are also some points that are worth adding, and this is what I follow for myself (disclaimer: educational purposes only).
PREVENTION:
- Minimize exposure
- Address nutritional deficiencies with sensitivity to Covid-19; immune support supplements
==> Test for Covid if experiencing symptoms, but only as a loose gauge due to limited accuracy
PHASE 1 (VIRAL REPLICATION):
- Increase T cells to prevent CD8 exhaustion, not NK which is assoc. w/ cytokine storm [3]
- Antivirals especially with specificity to CoV2 and CoV that target spike protein, TMPRSS2, and furin; other protein targets may be effective also. This step is critical in reducing viral load and significant immune response viral debris. Reduce viral load both systemically and in upper respiratory.
* Influenza shares the characteristic of being an enveloped RNA virus, and some treatments may have relevance. Must take it on a case by case basis.
==> Test for Covid, but only as a loose gauge due to limited accuracy
PHASE 2 (HYPER-INFLAMMATION):
- Stop immune enhancing treatments
- Promote Treg function
- Aggressively inhibit bradykinin to prevent Bradykinin Storm. [4]
- Promote ACE expression to help regulate Bradykinin
- Reduce inflammation (with anti-oxidants, anti-inflammatories, etc.)
I have a very detailed regimen around the above, and I can get into it more if folks are interested. Fortunately I haven't had to put it to the test yet. But I feel it includes all the latest science and leaves less gaps.
[1] https://www.who.int/...d-19-treatments
[2] https://www.evms.edu...19_Protocol.pdf
[3] https://science.scie...science.abc8511
[4] https://elifescience.../articles/59177
Edited by 9lives, 19 October 2020 - 04:14 AM.