Yes funny that you ask as i am currently using it. Both times yield different results.
I decided to give it a try after thinking that my 5ht1a can possibly be desensitised since the use of buspirone (5th1a agonist) and since valdoxan triggered my anxiety out of nowhere. I was depressed but I didn't have anxiety. Now I am far less depressed with less anhedonia but my anxiety levels have been peaking(before the use of cyproheptadine)
After reading that 5ht1a knock-out in mice exhibit anxiety behaviour and less depression.
I decided to try cyproheptadine again.
https://www.ncbi.nlm...icles/PMC24398/
1st time I used it for 3 days.
2mg
It had knocked me out. Next day I was extremely sedated,dull and cranky, bad mood, heavily depressed and lethargic, aggressive and literally no motivation and brain dead.My apetite was also increased.Similar to mirtazapine.
My state was already depressed at the time so it seemes that it just exacerbated the problem. Medication was still the same the only thing I haven't tried was valdoxan and Ritalin.
This time round I have have used it for the last 3 days to sleep which doesn't work to well.
2 mg or 4 mg at night 3 hours before bed along side my low dose prescription Ritalin in the morning.
It doesn't knock me out, it has reduced my anxiety and it doesn't increase my appetite. I feel good. I dont feel sedated at all.
I know that cyproheptadine can reverse depression post ssri treatment so I was actually expecting to be kinda depressed but No.
I will discontinue it in a few days once I feel I have antagonised enough my 5ht1a and see what happens.
I am also sure that I have downregulated my 5ht2c receptor as mirtazipine and cyproheptadine doesn't make me hungry anymore.
I am also starting to believe 5ht2a antagonist for me cause anhedonia and here is why in very simple words.
Ritalin is a 5ht1a agonist
https://pubmed.ncbi....h.gov/19322953/
At my current state I have no symptoms of anhedonia or depression, just mild anxiety. My 5ht1a gets agonised by the ritalin. Ritalin is a stimulant which suppresses apetite which makes me theorise that it must have some sort of a 5th2c effect as an antagonist through other mechanisms.
My 5ht2c is downregulated as I am never hungry anymore. Blockade by cyproheptadine is causing further downregulation. Therefore there must be more serotonin hitting my 5ht2a receptor which decreased my anhedonia.
Or it could just be ritalin increases my dopamine, cyproheptetine lowers my seratonin, therefore the positive outcomes.
I will update once I discontinue cyproheptadine.
Edited by Aj28, 27 March 2021 - 07:44 AM.