Does anyone here supplement L-Glutathione by itself or along with NAC? I'm already taking NAC, and I also thinking about incorporating L-Glutathione into my regimen. What do you all think?
Thanks!
Posted 07 June 2007 - 07:48 PM
Posted 07 June 2007 - 10:27 PM
Posted 08 June 2007 - 12:08 AM
Glutathione is not orally bioavailable.
Posted 08 June 2007 - 01:10 AM
Posted 08 June 2007 - 01:17 AM
or why they sell glutathione as a supplement? Well, the majority of supplements on the market aren't effective.
Posted 08 June 2007 - 01:26 AM
What do you think about pomegranate in enhancing glutathione shepard?
Posted 08 June 2007 - 05:13 AM
Posted 08 June 2007 - 03:31 PM
Posted 08 June 2007 - 04:10 PM
can someone post a study that documents the effectiveness of either NAC or whey protein in increasing glutathione?
Posted 08 June 2007 - 07:22 PM
Art De Vany is not the most credible source of information. Some of his stuff is worthwhile, some of it isn't. Of course glutathione is important, it's essential for life. Now, glutathione as a supplement isn't.
Considering the lack of impressiveness of that site (slight understatement) and the fact that I find no evidence to consider Dr. Demopoulos an authority of glutathione:
1. Why should I assume his supplement works?
2. Even if it does, why should I use it over other (cheaper) alternatives?
So, why take a chance on something that is more expensive and has extremely questionable effectiveness?can someone post a study that documents the effectiveness of either NAC or whey protein in increasing glutathione?
Instead of this, I would recommend getting a stronger grasp of glutathione in general. For example, start with understanding glutathione synthesis, what is the rate-limiting step, etc. etc.
Posted 08 June 2007 - 07:36 PM
Posted 08 June 2007 - 07:50 PM
can someone post a study that documents the effectiveness of either NAC or whey protein in increasing glutathione?
Posted 08 June 2007 - 07:59 PM
Posted 08 June 2007 - 08:01 PM
Posted 08 June 2007 - 08:07 PM
PHARMACOKINETICS
The pharmacokinetics of oral glutathionine in humans are not well understood. It appears that in some animals (mice, rats, guinea pigs), serum glutathione levels do increase following its oral administration. Most human studies of glutathione have not found this to be the case. It appears that oral glutathione is hydrolyzed in the intestine via the intestinal gamma-glutamyl transferase enzyme. A small amount of orally administered glutathione may reach the portal circulation, but apparently this is also rapidly metabolized by hepatic gamma-glutamyltransferase. Thus, most studies have not observed a significant increase in circulating glutathione following its oral administration. However, there is an occasional study that does show an increase in circulating glutathione after oral administration. Further, there is some evidence that glutathione may be absorbed into the enterocytes following ingestion, but may not be released by these cells into the circulation. Research is needed to resolve the issue of glutathione absorption.
Posted 08 June 2007 - 08:10 PM
Posted 08 June 2007 - 08:11 PM
Like I posted, you may be able to absorb Glutatione sublingually.
Posted 08 June 2007 - 08:38 PM
Like I posted, you may be able to absorb Glutatione sublingually.
Let's assume sublingual glutathione is effective. So if we attempt this directly, we've got sublingual, IV, and/or nebulous treatments.
What is your argument for this method instead of precursor supplementation?
There is no argument, I have been using everyway possible to increase my Glutathione levels as high as possible.
I might go subcutaneously too.
Alex Kalman
Posted 08 June 2007 - 08:52 PM
Is it possible to have too much of a good thing such as glutathione?
Posted 08 June 2007 - 09:01 PM
Like I posted, you may be able to absorb Glutatione sublingually.
Let's assume sublingual glutathione is effective. So if we attempt this directly, we've got sublingual, IV, and/or nebulous treatments.
What is your argument for this method instead of precursor supplementation?
There is no argument, I have been using everyway possible to increase my Glutathione levels as high as possible.
I might go subcutaneously too.
Alex Kalman
Do you use NAC also? Is it possible to have too much of a good thing such as glutathione?
Posted 08 June 2007 - 09:08 PM
Is it possible to have too much of a good thing such as glutathione?
I would lean between very likely to absolutely.
Posted 08 June 2007 - 09:45 PM
Do you have any references?
Posted 09 June 2007 - 05:49 AM
Do you have any references?
The topic is vast. I don't pretend to be all-knowing about it, but if you'll begin to look into what role hydrogen peroxide plays in the body you'll probably understand where I'm coming from.
If you're seriously interested, I'd recommend trying to find a copy of this book: http://www.amazon.co...81338904&sr=8-1
Posted 09 June 2007 - 07:23 AM
Because of hydrolysis of glutathione by intestinal and hepatic gamma-glutamyltransferase, dietary glutathione is not a major determinant of circulating glutathione, and it is not possible to increase circulating glutathione to a clinically beneficial extent by the oral administration of a single dose of 3 g of glutathione.
I have been dosing myself with various products that might raise my Glutathione levels for a couple of years.
I could explain to you why, but you probably would not be interested.
You are looking for longevity and I am looking for cell protection.
Posted 09 June 2007 - 03:12 PM
A scientific study published in a peer reviewed and reliable medical journal was quoted at the very start of this thread. This study concluded....
hence oral supplementation with glutathione is not advised. Now Alex, you use glutathione sublingually. This may or may not work. There is currently no published studies out there to demonstrate this. At least none that I have seen. Glutathione is a very important thiol and if it's bioavailability was increased by using sublingual glutathione then I'm betting that someone would have published something.
Instead though it has been shown on many occasions that increasing cysteine levels is a very effective method by which you can increase inracellular glutathione. Dietary cysteine comes from NAC and cysteine rich whey protein powders.
For some reason it seems as though you believe that sublingual glutathione works. That's fine of course but research shows that you are wasting your money and could be using cheaper alternatives.I have been dosing myself with various products that might raise my Glutathione levels for a couple of years.
I could explain to you why, but you probably would not be interested.
Please tell us Alex because
are essentially the same thing.
Posted 09 June 2007 - 10:37 PM
Posted 10 June 2007 - 02:17 AM
A scientific study published in a peer reviewed and reliable medical journal was quoted at the very start of this thread. This study concluded....
hence oral supplementation with glutathione is not advised. Now Alex, you use glutathione sublingually. This may or may not work. There is currently no published studies out there to demonstrate this. At least none that I have seen. Glutathione is a very important thiol and if it's bioavailability was increased by using sublingual glutathione then I'm betting that someone would have published something.
Instead though it has been shown on many occasions that increasing cysteine levels is a very effective method by which you can increase inracellular glutathione. Dietary cysteine comes from NAC and cysteine rich whey protein powders.
For some reason it seems as though you believe that sublingual glutathione works. That's fine of course but research shows that you are wasting your money and could be using cheaper alternatives.I have been dosing myself with various products that might raise my Glutathione levels for a couple of years.
I could explain to you why, but you probably would not be interested.
Please tell us Alex because
are essentially the same thing.
First of all, I am afraid to post this to you.
If I reveal this tidbit of info, shall I receive any credit or references for my knowledge?
Alex Kalman
Posted 10 June 2007 - 03:53 AM
Posted 10 June 2007 - 04:21 AM
Posted 10 June 2007 - 05:34 AM
Shep, agreed. The oxidized glutathione (GSSG) is the by product the reaction and not the catalyst. Your supplementing with the wrong end my friend.
Reduced glutathione (GSH) acts as the substrate in the reaction and is used to neutralize hydrogen peroxide via glutathione peroxidase (GPx) or catalase.
I can tell you from first hand experience because I have measured changes in plasma cysteine and intracellular reduced, oxidized and Total Glutathione in aged male that whey protein supplementation is sufficient enough to increase one's GSH level and hence change the redox status of the cell minimizing oxidative stress.
To increase GSH levels you can also supplement with alpha-lipoic acid
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