19 replies to this topic

[ppp]

This is a somewhat surprising and very worrying development (given that my son is on resveratrol and docetaxel - a chemo drug related to pacitaxel):

Eur J Cancer. 2010 Mar 9.
Resveratrol attenuates the anticancer efficacy of paclitaxel in human breast cancer cells invitro and in vivo.

Fukui M, Yamabe N, Zhu BT.

Department of Pharmacology, Toxicology and Therapeutics, School of Medicine, University of Kansas Medical Center, Kansas City, KS 66160, USA.

It was reported recently that resveratrol could sensitise a number of cancer cell lines to the anticancer actions of several other cancer drugs, including paclitaxel. In the present study, we further investigated whether resveratrol could sensitise human breast cancer cells to paclitaxel-induced cell death. Unexpectedly, we found that resveratrol strongly diminished the susceptibility of MDA-MB-435s, MDA-MB-231 and SKBR-3 cells to paclitaxel-induced cell death in culture, although this effect was not observed in MCF-7 cells. Using MDA-MB-435s cells as a representative model, a similar observation was made in athymic nude mice. Mechanistically, the modulating effect of resveratrol was partially attributable to its inhibition of paclitaxel-induced G(2)/M cell cycle arrest, together with an accumulation of cells in the S-phase. In addition, resveratrol could suppress paclitaxel-induced accumulation of reactive oxygen species (ROS) and subsequently the inactivation of anti-apoptotic Bcl-2 family proteins. These observations suggest that the strategy of concomitant use of resveratrol with paclitaxel is detrimental in certain types of human cancers. Given the widespread use of resveratrol among cancer patients, this study calls for more preclinical and clinical testing of the potential benefits and harms of using resveratrol as a dietary adjuvant in cancer patients.

Comments, anyone?

[browser]

This is a somewhat surprising and very worrying development (given that my son is on resveratrol and docetaxel - a chemo drug related to pacitaxel):

Eur J Cancer. 2010 Mar 9.
Resveratrol attenuates the anticancer efficacy of paclitaxel in human breast cancer cells invitro and in vivo.

Fukui M, Yamabe N, Zhu BT.

Department of Pharmacology, Toxicology and Therapeutics, School of Medicine, University of Kansas Medical Center, Kansas City, KS 66160, USA.

It was reported recently that resveratrol could sensitise a number of cancer cell lines to the anticancer actions of several other cancer drugs, including paclitaxel. In the present study, we further investigated whether resveratrol could sensitise human breast cancer cells to paclitaxel-induced cell death. Unexpectedly, we found that resveratrol strongly diminished the susceptibility of MDA-MB-435s, MDA-MB-231 and SKBR-3 cells to paclitaxel-induced cell death in culture, although this effect was not observed in MCF-7 cells. Using MDA-MB-435s cells as a representative model, a similar observation was made in athymic nude mice. Mechanistically, the modulating effect of resveratrol was partially attributable to its inhibition of paclitaxel-induced G(2)/M cell cycle arrest, together with an accumulation of cells in the S-phase. In addition, resveratrol could suppress paclitaxel-induced accumulation of reactive oxygen species (ROS) and subsequently the inactivation of anti-apoptotic Bcl-2 family proteins. These observations suggest that the strategy of concomitant use of resveratrol with paclitaxel is detrimental in certain types of human cancers. Given the widespread use of resveratrol among cancer patients, this study calls for more preclinical and clinical testing of the potential benefits and harms of using resveratrol as a dietary adjuvant in cancer patients.

Comments, anyone?

I have prostate cancer. I'm getting Vitamin C IVs to stimulate my immune system and also create ROS to kill cancer cells. I'm also taking at least 3 grams of Resveratrol a day in the form of Nitro 250 plus buccal Resveratrol powder. Bill Sardi of Longev* started me off on Resveratrol. Bill told me the mechanism by which Resveratrol at higher doses would kill cancer is oxidation, i.e. ROS. The literature shows Bill's statement was wrong. Bill told me to take 10 grams of fish oil daily to aid in the oxidation and that the IVC would help in the oxidation. Well, it looks as though Resveratrol is actually preventing the IVC from killing cancer cells with ROS. Dr. Snuffy Myers, the prostate cancer survivor and expert prostate cancer prostate cancer oncologist tells his patients to take 500-1000 mg. each of Resveratrol and Quercetin in the form of Nitro 250 and MCT Quercetin but that prostate cancer patients should only take Resveratrol while under the care of a physician who knows all the medical implications of Resveratrol. This is better said than done since use of Resveratrol is very new and scarcely researched.

Thanks for the very helpful post. More things to ponder.

[ppp]

This is a somewhat surprising and very worrying development (given that my son is on resveratrol and docetaxel - a chemo drug related to pacitaxel):

Eur J Cancer. 2010 Mar 9.
Resveratrol attenuates the anticancer efficacy of paclitaxel in human breast cancer cells invitro and in vivo.

Fukui M, Yamabe N, Zhu BT.

Department of Pharmacology, Toxicology and Therapeutics, School of Medicine, University of Kansas Medical Center, Kansas City, KS 66160, USA.

It was reported recently that resveratrol could sensitise a number of cancer cell lines to the anticancer actions of several other cancer drugs, including paclitaxel. In the present study, we further investigated whether resveratrol could sensitise human breast cancer cells to paclitaxel-induced cell death. Unexpectedly, we found that resveratrol strongly diminished the susceptibility of MDA-MB-435s, MDA-MB-231 and SKBR-3 cells to paclitaxel-induced cell death in culture, although this effect was not observed in MCF-7 cells. Using MDA-MB-435s cells as a representative model, a similar observation was made in athymic nude mice. Mechanistically, the modulating effect of resveratrol was partially attributable to its inhibition of paclitaxel-induced G(2)/M cell cycle arrest, together with an accumulation of cells in the S-phase. In addition, resveratrol could suppress paclitaxel-induced accumulation of reactive oxygen species (ROS) and subsequently the inactivation of anti-apoptotic Bcl-2 family proteins. These observations suggest that the strategy of concomitant use of resveratrol with paclitaxel is detrimental in certain types of human cancers. Given the widespread use of resveratrol among cancer patients, this study calls for more preclinical and clinical testing of the potential benefits and harms of using resveratrol as a dietary adjuvant in cancer patients.

Comments, anyone?

I have prostate cancer. I'm getting Vitamin C IVs to stimulate my immune system and also create ROS to kill cancer cells. I'm also taking at least 3 grams of Resveratrol a day in the form of Nitro 250 plus buccal Resveratrol powder. Bill Sardi of Longev* started me off on Resveratrol. Bill told me the mechanism by which Resveratrol at higher doses would kill cancer is oxidation, i.e. ROS. The literature shows Bill's statement was wrong. Bill told me to take 10 grams of fish oil daily to aid in the oxidation and that the IVC would help in the oxidation. Well, it looks as though Resveratrol is actually preventing the IVC from killing cancer cells with ROS. Dr. Snuffy Myers, the prostate cancer survivor and expert prostate cancer prostate cancer oncologist tells his patients to take 500-1000 mg. each of Resveratrol and Quercetin in the form of Nitro 250 and MCT Quercetin but that prostate cancer patients should only take Resveratrol while under the care of a physician who knows all the medical implications of Resveratrol. This is better said than done since use of Resveratrol is very new and scarcely researched.

Thanks for the very helpful post. More things to ponder.

The thing about Quercetin is that it's a very strong inducer of Nrf2 - which drives the anti-oxidant response that protects the cell from oxidative damage...

[browser]

This is a somewhat surprising and very worrying development (given that my son is on resveratrol and docetaxel - a chemo drug related to pacitaxel):

Eur J Cancer. 2010 Mar 9.
Resveratrol attenuates the anticancer efficacy of paclitaxel in human breast cancer cells invitro and in vivo.

Fukui M, Yamabe N, Zhu BT.

Department of Pharmacology, Toxicology and Therapeutics, School of Medicine, University of Kansas Medical Center, Kansas City, KS 66160, USA.

It was reported recently that resveratrol could sensitise a number of cancer cell lines to the anticancer actions of several other cancer drugs, including paclitaxel. In the present study, we further investigated whether resveratrol could sensitise human breast cancer cells to paclitaxel-induced cell death. Unexpectedly, we found that resveratrol strongly diminished the susceptibility of MDA-MB-435s, MDA-MB-231 and SKBR-3 cells to paclitaxel-induced cell death in culture, although this effect was not observed in MCF-7 cells. Using MDA-MB-435s cells as a representative model, a similar observation was made in athymic nude mice. Mechanistically, the modulating effect of resveratrol was partially attributable to its inhibition of paclitaxel-induced G(2)/M cell cycle arrest, together with an accumulation of cells in the S-phase. In addition, resveratrol could suppress paclitaxel-induced accumulation of reactive oxygen species (ROS) and subsequently the inactivation of anti-apoptotic Bcl-2 family proteins. These observations suggest that the strategy of concomitant use of resveratrol with paclitaxel is detrimental in certain types of human cancers. Given the widespread use of resveratrol among cancer patients, this study calls for more preclinical and clinical testing of the potential benefits and harms of using resveratrol as a dietary adjuvant in cancer patients.

Comments, anyone?

I have prostate cancer. I'm getting Vitamin C IVs to stimulate my immune system and also create ROS to kill cancer cells. I'm also taking at least 3 grams of Resveratrol a day in the form of Nitro 250 plus buccal Resveratrol powder. Bill Sardi of Longev* started me off on Resveratrol. Bill told me the mechanism by which Resveratrol at higher doses would kill cancer is oxidation, i.e. ROS. The literature shows Bill's statement was wrong. Bill told me to take 10 grams of fish oil daily to aid in the oxidation and that the IVC would help in the oxidation. Well, it looks as though Resveratrol is actually preventing the IVC from killing cancer cells with ROS. Dr. Snuffy Myers, the prostate cancer survivor and expert prostate cancer prostate cancer oncologist tells his patients to take 500-1000 mg. each of Resveratrol and Quercetin in the form of Nitro 250 and MCT Quercetin but that prostate cancer patients should only take Resveratrol while under the care of a physician who knows all the medical implications of Resveratrol. This is better said than done since use of Resveratrol is very new and scarcely researched.

Thanks for the very helpful post. More things to ponder.

The thing about Quercetin is that it's a very strong inducer of Nrf2 - which drives the anti-oxidant response that protects the cell from oxidative damage...

I'm aware of that. I'm taking the high dose of Resvaratrol for its other chemo effects. I'm taking the Quercetin to make sure the potent dose of Resveratrol isn't deactivated during first pass by the liver. I'm looking for info on just how much Resveratrol taken at one time will swamp the liver's action against. Any ideas?

[ppp]

This is a somewhat surprising and very worrying development (given that my son is on resveratrol and docetaxel - a chemo drug related to pacitaxel):

Eur J Cancer. 2010 Mar 9.
Resveratrol attenuates the anticancer efficacy of paclitaxel in human breast cancer cells invitro and in vivo.

Fukui M, Yamabe N, Zhu BT.

Department of Pharmacology, Toxicology and Therapeutics, School of Medicine, University of Kansas Medical Center, Kansas City, KS 66160, USA.

It was reported recently that resveratrol could sensitise a number of cancer cell lines to the anticancer actions of several other cancer drugs, including paclitaxel. In the present study, we further investigated whether resveratrol could sensitise human breast cancer cells to paclitaxel-induced cell death. Unexpectedly, we found that resveratrol strongly diminished the susceptibility of MDA-MB-435s, MDA-MB-231 and SKBR-3 cells to paclitaxel-induced cell death in culture, although this effect was not observed in MCF-7 cells. Using MDA-MB-435s cells as a representative model, a similar observation was made in athymic nude mice. Mechanistically, the modulating effect of resveratrol was partially attributable to its inhibition of paclitaxel-induced G(2)/M cell cycle arrest, together with an accumulation of cells in the S-phase. In addition, resveratrol could suppress paclitaxel-induced accumulation of reactive oxygen species (ROS) and subsequently the inactivation of anti-apoptotic Bcl-2 family proteins. These observations suggest that the strategy of concomitant use of resveratrol with paclitaxel is detrimental in certain types of human cancers. Given the widespread use of resveratrol among cancer patients, this study calls for more preclinical and clinical testing of the potential benefits and harms of using resveratrol as a dietary adjuvant in cancer patients.

Comments, anyone?

I have prostate cancer. I'm getting Vitamin C IVs to stimulate my immune system and also create ROS to kill cancer cells. I'm also taking at least 3 grams of Resveratrol a day in the form of Nitro 250 plus buccal Resveratrol powder. Bill Sardi of Longev* started me off on Resveratrol. Bill told me the mechanism by which Resveratrol at higher doses would kill cancer is oxidation, i.e. ROS. The literature shows Bill's statement was wrong. Bill told me to take 10 grams of fish oil daily to aid in the oxidation and that the IVC would help in the oxidation. Well, it looks as though Resveratrol is actually preventing the IVC from killing cancer cells with ROS. Dr. Snuffy Myers, the prostate cancer survivor and expert prostate cancer prostate cancer oncologist tells his patients to take 500-1000 mg. each of Resveratrol and Quercetin in the form of Nitro 250 and MCT Quercetin but that prostate cancer patients should only take Resveratrol while under the care of a physician who knows all the medical implications of Resveratrol. This is better said than done since use of Resveratrol is very new and scarcely researched.

Thanks for the very helpful post. More things to ponder.

The thing about Quercetin is that it's a very strong inducer of Nrf2 - which drives the anti-oxidant response that protects the cell from oxidative damage...

I'm aware of that. I'm taking the high dose of Resvaratrol for its other chemo effects. I'm taking the Quercetin to make sure the potent dose of Resveratrol isn't deactivated during first pass by the liver. I'm looking for info on just how much Resveratrol taken at one time will swamp the liver's action against. Any ideas?

Nothing concrete. However, it seemed to me that synergism with curcumin is a line of inquiry worth following. Not only does curcumin attack multiple cancer pathways, it also inhibits liver metabolism to some extent. Have you looked at this?

This is a real minefield - the anti-cancer effects of resveratrol vary by cell line even within cancer subtype... I guess that's to be expected given the complex genomic instability of cancer but it makes it hard to make a decision in the absence of well validated clinical trials.

Edited by ppp, 16 March 2010 - 08:41 PM.

[bixbyte]

This is a somewhat surprising and very worrying development (given that my son is on resveratrol and docetaxel - a chemo drug related to pacitaxel):

Eur J Cancer. 2010 Mar 9.
Resveratrol attenuates the anticancer efficacy of paclitaxel in human breast cancer cells invitro and in vivo.

Fukui M, Yamabe N, Zhu BT.

Department of Pharmacology, Toxicology and Therapeutics, School of Medicine, University of Kansas Medical Center, Kansas City, KS 66160, USA.

It was reported recently that resveratrol could sensitise a number of cancer cell lines to the anticancer actions of several other cancer drugs, including paclitaxel. In the present study, we further investigated whether resveratrol could sensitise human breast cancer cells to paclitaxel-induced cell death. Unexpectedly, we found that resveratrol strongly diminished the susceptibility of MDA-MB-435s, MDA-MB-231 and SKBR-3 cells to paclitaxel-induced cell death in culture, although this effect was not observed in MCF-7 cells. Using MDA-MB-435s cells as a representative model, a similar observation was made in athymic nude mice. Mechanistically, the modulating effect of resveratrol was partially attributable to its inhibition of paclitaxel-induced G(2)/M cell cycle arrest, together with an accumulation of cells in the S-phase. In addition, resveratrol could suppress paclitaxel-induced accumulation of reactive oxygen species (ROS) and subsequently the inactivation of anti-apoptotic Bcl-2 family proteins. These observations suggest that the strategy of concomitant use of resveratrol with paclitaxel is detrimental in certain types of human cancers. Given the widespread use of resveratrol among cancer patients, this study calls for more preclinical and clinical testing of the potential benefits and harms of using resveratrol as a dietary adjuvant in cancer patients.

Comments, anyone?

Comment, If you have Cancer throw out your Resveratrol, the study suggests Resveratrol deactivates Taxol chemotherapy efficacy in certain Cell lines.

We might be able to say, AVOID Taking any ANTIOXIDANTS or VITAMINS if we have Cancer.

[maxwatt]

This is a somewhat surprising and very worrying development (given that my son is on resveratrol and docetaxel - a chemo drug related to pacitaxel):

Eur J Cancer. 2010 Mar 9.
Resveratrol attenuates the anticancer efficacy of paclitaxel in human breast cancer cells invitro and in vivo.

Fukui M, Yamabe N, Zhu BT.

Department of Pharmacology, Toxicology and Therapeutics, School of Medicine, University of Kansas Medical Center, Kansas City, KS 66160, USA.

It was reported recently that resveratrol could sensitise a number of cancer cell lines to the anticancer actions of several other cancer drugs, including paclitaxel. In the present study, we further investigated whether resveratrol could sensitise human breast cancer cells to paclitaxel-induced cell death. Unexpectedly, we found that resveratrol strongly diminished the susceptibility of MDA-MB-435s, MDA-MB-231 and SKBR-3 cells to paclitaxel-induced cell death in culture, although this effect was not observed in MCF-7 cells. Using MDA-MB-435s cells as a representative model, a similar observation was made in athymic nude mice. Mechanistically, the modulating effect of resveratrol was partially attributable to its inhibition of paclitaxel-induced G(2)/M cell cycle arrest, together with an accumulation of cells in the S-phase. In addition, resveratrol could suppress paclitaxel-induced accumulation of reactive oxygen species (ROS) and subsequently the inactivation of anti-apoptotic Bcl-2 family proteins. These observations suggest that the strategy of concomitant use of resveratrol with paclitaxel is detrimental in certain types of human cancers. Given the widespread use of resveratrol among cancer patients, this study calls for more preclinical and clinical testing of the potential benefits and harms of using resveratrol as a dietary adjuvant in cancer patients.

Comments, anyone?

Comment, If you have Cancer throw out your Resveratrol, the study suggests Resveratrol deactivates Taxol chemotherapy efficacy in certain Cell lines.

We might be able to say, AVOID Taking any ANTIOXIDANTS or VITAMINS if we have Cancer.

Not so fast. It depends on the strain of cancer. There are many. Most respond. Some do not. It depends on which mutated pathways a particular cell line is vulnerable to, or depends on, and which ones resveratrol activates or blocks. Small cell lung cancer does not respond to resveratrol, though it does not seem to exacerbate it. Many if not all breast cancer cell lines respond, and perhaps prostate cancer does as well -- there seems to be some in vitro evidence. Vitamin C antagonizes the action of some cancer treatments, yet IV vitamin C kills other types of cancer, Perhaps taking a biopsy of the cancer cells, and testing them in the lab, will be the way to go.

[ppp]

Not so fast. It depends on the strain of cancer. There are many. Most respond. Some do not. It depends on which mutated pathways a particular cell line is vulnerable to, or depends on, and which ones resveratrol activates or blocks. Small cell lung cancer does not respond to resveratrol, though it does not seem to exacerbate it. Many if not all breast cancer cell lines respond, and perhaps prostate cancer does as well -- there seems to be some in vitro evidence. Vitamin C antagonizes the action of some cancer treatments, yet IV vitamin C kills other types of cancer, Perhaps taking a biopsy of the cancer cells, and testing them in the lab, will be the way to go.

I agree - but for the moment the state of knowledge is such that we don't know enough about any of this stuff. For instance, in vitro we know that resveratrol causes apoptosis of a range of osteosarcoma cells lines - but the in vivo work in rats hasn't been done yet, which makes it difficult to extrapolate. Very often cancer patients have to make a judgement call - does a result that work for this mean that it will work in my cancer? These aren't easy decisions to make. The value of forums like this one is that it makes a discussion possible because most oncologists will not engage in the conversation at all...

[maxwatt]

I have had a chance to scan the paper, and indeed the interaction with resveratrol is very much dependent on type of cancer and type of drug. And Vitamin E has the same effect vis-a-vis ROS inhibition with paclitaxel. IF possible, one should biops the patients' cancer, culture it, and see what the effect is in vitro.

[browser]

This is a somewhat surprising and very worrying development (given that my son is on resveratrol and docetaxel - a chemo drug related to pacitaxel):

Eur J Cancer. 2010 Mar 9.
Resveratrol attenuates the anticancer efficacy of paclitaxel in human breast cancer cells invitro and in vivo.

Fukui M, Yamabe N, Zhu BT.

Department of Pharmacology, Toxicology and Therapeutics, School of Medicine, University of Kansas Medical Center, Kansas City, KS 66160, USA.

It was reported recently that resveratrol could sensitise a number of cancer cell lines to the anticancer actions of several other cancer drugs, including paclitaxel. In the present study, we further investigated whether resveratrol could sensitise human breast cancer cells to paclitaxel-induced cell death. Unexpectedly, we found that resveratrol strongly diminished the susceptibility of MDA-MB-435s, MDA-MB-231 and SKBR-3 cells to paclitaxel-induced cell death in culture, although this effect was not observed in MCF-7 cells. Using MDA-MB-435s cells as a representative model, a similar observation was made in athymic nude mice. Mechanistically, the modulating effect of resveratrol was partially attributable to its inhibition of paclitaxel-induced G(2)/M cell cycle arrest, together with an accumulation of cells in the S-phase. In addition, resveratrol could suppress paclitaxel-induced accumulation of reactive oxygen species (ROS) and subsequently the inactivation of anti-apoptotic Bcl-2 family proteins. These observations suggest that the strategy of concomitant use of resveratrol with paclitaxel is detrimental in certain types of human cancers. Given the widespread use of resveratrol among cancer patients, this study calls for more preclinical and clinical testing of the potential benefits and harms of using resveratrol as a dietary adjuvant in cancer patients.

Comments, anyone?

Comment, If you have Cancer throw out your Resveratrol, the study suggests Resveratrol deactivates Taxol chemotherapy efficacy in certain Cell lines.

We might be able to say, AVOID Taking any ANTIOXIDANTS or VITAMINS if we have Cancer.

Not so fast. It depends on the strain of cancer. There are many. Most respond. Some do not. It depends on which mutated pathways a particular cell line is vulnerable to, or depends on, and which ones resveratrol activates or blocks. Small cell lung cancer does not respond to resveratrol, though it does not seem to exacerbate it. Many if not all breast cancer cell lines respond, and perhaps prostate cancer does as well -- there seems to be some in vitro evidence. Vitamin C antagonizes the action of some cancer treatments, yet IV vitamin C kills other types of cancer, Perhaps taking a biopsy of the cancer cells, and testing them in the lab, will be the way to go.

I know that prostate cancer is killed by IV Vitamin C. Brightspot.org does this day and night.

The thought occurred to me that this study just might be flawed. It happens. Later reports might prove this one wrong. Then again cancer isn't a single disease nor are the various strains which attack an organ so it's entirely possible Resveratrol use will have to be evaluated for each cell line.

Now one question is would the people in the study be better off taking the Taxol chemo or high doses of Resveratrol?

[browser]

This is a somewhat surprising and very worrying development (given that my son is on resveratrol and docetaxel - a chemo drug related to pacitaxel):

Eur J Cancer. 2010 Mar 9.
Resveratrol attenuates the anticancer efficacy of paclitaxel in human breast cancer cells invitro and in vivo.

Fukui M, Yamabe N, Zhu BT.

Department of Pharmacology, Toxicology and Therapeutics, School of Medicine, University of Kansas Medical Center, Kansas City, KS 66160, USA.

It was reported recently that resveratrol could sensitise a number of cancer cell lines to the anticancer actions of several other cancer drugs, including paclitaxel. In the present study, we further investigated whether resveratrol could sensitise human breast cancer cells to paclitaxel-induced cell death. Unexpectedly, we found that resveratrol strongly diminished the susceptibility of MDA-MB-435s, MDA-MB-231 and SKBR-3 cells to paclitaxel-induced cell death in culture, although this effect was not observed in MCF-7 cells. Using MDA-MB-435s cells as a representative model, a similar observation was made in athymic nude mice. Mechanistically, the modulating effect of resveratrol was partially attributable to its inhibition of paclitaxel-induced G(2)/M cell cycle arrest, together with an accumulation of cells in the S-phase. In addition, resveratrol could suppress paclitaxel-induced accumulation of reactive oxygen species (ROS) and subsequently the inactivation of anti-apoptotic Bcl-2 family proteins. These observations suggest that the strategy of concomitant use of resveratrol with paclitaxel is detrimental in certain types of human cancers. Given the widespread use of resveratrol among cancer patients, this study calls for more preclinical and clinical testing of the potential benefits and harms of using resveratrol as a dietary adjuvant in cancer patients.

Comments, anyone?

Comment, If you have Cancer throw out your Resveratrol, the study suggests Resveratrol deactivates Taxol chemotherapy efficacy in certain Cell lines.

We might be able to say, AVOID Taking any ANTIOXIDANTS or VITAMINS if we have Cancer.

Not so fast. It depends on the strain of cancer. There are many. Most respond. Some do not. It depends on which mutated pathways a particular cell line is vulnerable to, or depends on, and which ones resveratrol activates or blocks. Small cell lung cancer does not respond to resveratrol, though it does not seem to exacerbate it. Many if not all breast cancer cell lines respond, and perhaps prostate cancer does as well -- there seems to be some in vitro evidence. Vitamin C antagonizes the action of some cancer treatments, yet IV vitamin C kills other types of cancer, Perhaps taking a biopsy of the cancer cells, and testing them in the lab, will be the way to go.

I know that prostate cancer is killed by IV Vitamin C. Brightspot.org does this day and night.

The thought occurred to me that this study just might be flawed. It happens. Later reports might prove this one wrong. Then again cancer isn't a single disease nor are the various strains which attack an organ so it's entirely possible Resveratrol use will have to be evaluated for each cell line.

Now one question is would the people in the study be better off taking the Taxol chemo or high doses of Resveratrol?

I just got my labs back. It appears that the 800 mg. a day of RESV in Longev* as suggested by Bill Sard1 was a bad idea. My PSA, which had been declining with the Vitamin C IVs and the IP6+Inositol rose by 27% with the 800 mg. Longev* RESV. I've only been on 3 grams of the Nitro 250 RESV and MCT Quercetin for 11 days but I agree with Maxwatt about the Quercetin being a bad idea.

Maxwatt, can I get enough curcumin into my blood stream to prevent sulphonation of RESV? I'm looking at taking 12 grams of curcumin ??dissolved?? in hot coconut milk then cooled down. I'd switch to just micronized Resveratrol, which I might mix into the coconut milk. Since whole milk and whey protein have been used as dispersal agents for RESV, it seems to me I can kill two birds with one stone and mix, say 5 grams of micronized RESV into the hot coconut milk. Any thoughts? Also, I'm searching for which CYP enzyme sulphonates RESV but I'm coming up dry. Would you know which CYP enzyme it is, Maxwatt?

Any clues on how much RESV taken at a time would swamp the liver's ability to sulphonate it?



Here's a patent application for curcumin and resveratrol I came upon. It specifically mentions prostate cancer and PSA.

Patent application title: PHARMACEUTICAL COMPOSITION COMPRISING CURCUMIN AND RESVERATROL AND USES THEREOF IN MEDICAL FIELD
Inventors: Damiano Turini Stefan Coccoloni
Agents: YOUNG & THOMPSON
Assignees:
Origin: ALEXANDRIA, VA US
IPC8 Class: AA61K3112FI
USPC Class: 424765


Abstract:
The present invention concerns a pharmaceutical composition containing curcumin and resveratrol and its application in the medical field. In particular, the composition according to the invention can be advantageously employed for preventing ageing and vascular diseases, for the treatment and the prophylaxis of cancers as prostate carcinoma, of skin diseases as psoriasis, and of the piliferous system as hair loss.
Claims:
1. Pharmaceutical composition comprising resveratrol and/or the root of polygonum cuspidatum containing resveratrol, and curcumin and/or root of the curcuma longa containing curcumin, as active principles in association with one or more pharmaceutically acceptable adjuvants and/or excipients.

2. Pharmaceutical composition according to claim 1, that further comprises vitamin E and/or wheat germs containing vitamin E.

3. Pharmaceutical composition according to claim 1, that further comprises vitamin C and/or berries of Rosa canina containing vitamin C.

4. Pharmaceutical composition according to claim 1, that further comprises capsaicin and/or the fruit of capsicum annum containing capsaicin.

5. Pharmaceutical composition according to claim 1, wherein the resveratrol content ranges from 3 to 6 mg.

6. Pharmaceutical composition according to claim 1, wherein the curcumin content ranges from 15 to 30 mg.

7. Pharmaceutical composition according to claim 1, wherein the content of vitamin E ranges from 50 to 100 mg.

8. Pharmaceutical composition according to claim 1, wherein the content of vitamin C ranges from 10 to 30 mg.

9. Pharmaceutical composition according to claim 1, wherein the content of capsaicin ranges from 2 to 5 mg.

10. Pharmaceutical composition according to claim 1, wherein the content of powdered wheat germs ranges from 50 to 450 mg.

11. Composition according to claim 10, wherein the content of powdered wheat germs ranges from 100 to 350 mg.

12. Composition according to claim 1, wherein the content of powdered berries of Rosa canina ranges from 50 to 450 mg.

13. Composition according to claim 12, wherein the content of powdered berries of Rosa canina ranges from 100 to 350 mg.

14. Composition according to claim 1, wherein the content of the powdered fruit of capsicum annum ranges from 50 to 450 mg.

15. Composition according to claim 14, wherein the content of powdered fruits of capsicum annum ranges from 100 to 350 mg.

16. Composition according to claim 1, wherein the content of powdered roots of Curcuma longa ranges from 1 to 100 mg.

17. Composition according to claim 16, wherein the content of powdered roots of Curcuma longa ranges from 50 to 100 mg.

18. Composition according to claim 1, wherein the content of powdered roots of polygonum cuspidatum varies from 1 to 100 mg.

19. Composition according to claim 18, wherein the content of powdered roots of ranges from 50 to 100 mg.

20. Pharmaceutical composition according to claim 1, comprising:Rosa canina (titrated dried extracts) 10%; 150.00 mg of natural vitamin C; 15.00 mg of synthetic vitamin C,Curcuma (titrated dried extract) 95%; 20.60 mg of Curcumin, 20.00 mg. of synthetic Curcumin,Poligonum cuspidatum (titrated dried extract) 98%; 5.10 mg of resveratrol; 5.00 mg of synthetic resveratrol,60.00 mg of wheat germ oil,Capsicum, (titrated dry extract) 60% in Capsaicin 5 mg; 3.00 mg of synthetic capsaicin.

21. Composition according to claim 1 presented in the form of capsules, pills, solution or emulsion.

22-29. (canceled)

30. Combination comprising resveratrol and curcumin for the simultaneous, separate or sequential use in the treatment of cancer.

31. Combination according to claim 30, wherein cancer is the prostate cancer.

32. Combination comprising resveratrol and Curcumin for the simultaneous, separate or sequential use in the treatment of skin diseases.

33. Combination according to claim 32, wherein the skin disease is psoriasis.

34. Combination comprising resveratrol and curcumin for the simultaneous, separate or sequential use in the treatment and the prevention of alopecia.

35. A method for treating a patient having cancer, comprising administering to said patient in need thereof an effective amount of the pharmaceutical composition according to claim 1.

36. The method according to claim 35, wherein said patient has prostate carcinoma.

37. A method for treating a patient having a skindisease, comprising administering to said patient in need thereof an effective amount of the pharmaceutical composition according to claim 1.

38. The method according to claim 37, wherein said patient has psoriasis.

39. A method for the treatment and prevention of ageing in a patient, comprising administering to said patient in need thereof an effective amount of the pharmaceutical composition according to claim 1.

40. A method for the treatment and prevention of vascular disease in a patient, comprising administering to said patient in need thereof an effective amount of the pharmaceutical composition according to claim 1.

41. A method for the treatment and prevention of a pilferous system disease in a patient, comprising administering to said patient in need thereof an effective amount of the pharmaceutical composition according to claim 1.

42. The method according to claim 41, wherein said patient has alopecia.
Description:
[0001]The present invention deals with a pharmaceutical composition comprising curcumin and resveratrol and uses thereof in medical field. More specifically, the composition object of the invention can be advantageously employed for retarding ageing, for the prevention of vascular diseases, for the treatment and prevention of cancers as, for example, prostate carcinoma, skin diseases as psoriasis, and diseases of the piliferous system as hair loss.

[0002]Resveratrol is a polyphenol present in grapes, especially in its peel and in its seeds, but also in a plant, the Polygonum Cuspidatum. Numbers of scientific researches have shown the in vitro efficacy of the Resveratrol in reducing the proliferation of human carcinogenic cells (Annals of the New York Academy of Science 957:210-229 (2002); Anticancer Res. 2004 September-October, 24(5A):2783-840; J. Urol. 2002 August 168(2):748-55; Biochem Pharmacol 2004 Sep. 15 68(6):1113-8; Drugs exp clin Res 2003 29(5-6):257-61). Moreover, the regular use of red wine in France could explain the so-called "French Paradox", that is the low incidence of coronary diseases in French population even if its diet has a high fat content.

[0003]The researches carried out by D. Sinclair and others, published on the magazine NATURE ((2789-Sep. 7, 2004-VBCKNELL-111861), aroused great interest by considering the opportunity of a life extension in good conditions. The researches are based on data dated many years ago that showed that a controlled diet prolonged life of the Drosophila Melanogaster, even if as side effect the animal manifested drowsiness. It has been shown that the admixture of resveratrol to diet gives the same results of a controlled diet, but eliminating any negative side effect.

[0004]Moreover Sinclair, who discovered the ability of Resveratrol of prolonging the life of yeasts, tried it on fruit-flies and small worms that have biological processes similar to the human ones. He ascertained an increased activity and fertility, together with a greater egg production.

[0005]Curcumin is an extract of the root of the Curcumea Longa, a plant well known since a long time for its pharmaceutical properties. Nowadays curcumin is well known for its power of reducing cholesterol, its diuretic, choleretic, anti-inflammatory ability and for ameliorating the general conditions of patients treated with chemotherapy for neoplasia.

[0006]Particular feature of Curcumin is to belong to the capsaicinoids family, substances characterized by a pungent taste, similar to the one of pepper. From a point of view of molecular biology, the presence of a vanilloid receptor on the cell membrane and close to the mitochondrial structures can explain the induction of apoptosis or planned death of cells that would have become neoplastic. Moreover, in the Central Nervous System there are various receptors of capsaicinoids and this could explain the enhancement of the anti-aging action of resveratrol by curcumin.

[0007]The authors of the present invention, starting from the recognized anti-inflammable and anti-neoplastic action of resveratrol and curcumin, have tested two mixtures with an antioxidant action. The first one is made of basically resveratrol (called Resverage) and the other one made of resveratrol and curcumin (called Capsures). The mixtures have been packaged in capsules for oral use. At the beginning the compounds have been administered to patients with prostate carcinoma insensible to hormones. The choice of these patients depends of the fact that the evolution of neoplasia can easily be monitored by the prostate-specific antigens (PSA).

[0008]The group of patients that has assumed only resveratrol didn't show any modification on the PSA, while the group treated with resveratrol and curcumin showed with great surprise a reduction, sometimes also relevant, in variable time periods.

[0009]Moreover, during this testing, the patients treated with resveratrol and curcumin surprisingly showed positive improvements in the treatment of psoriasis and the attenuation and even a stop of the hair loss, a reduction of the hair graying and the rebirth of hair in bald areas sometimes even of the original color too. This aspect polarized the attention and the mechanism that ruled the association of the two substances became the object of the studies. The physic and pathologic basis of the action of the association of resveratrol and curcumin can be found in the relationship existing between the congenital hypo-sensitization of the sensory fibers of rats and the skin lesions similar to psoriatic lesions. In that case, the administration of a substance that reactivates the skin tropism would open new ways to the treatment of skin lesions. A possible theory is that it is possible to stimulate the peripheral sensory fibers with tropic function by associating curcumin and resveratrol. Regarding its action on hair growth, even if not yet known, it is probably linked to the release of P substance. The growth and the pigmentation of the hair follicle would depend on mesenchymal-epithelium-neiroderic interactions not very well-known yet, where the P substance would stimulate the hair growth in vivo (Ralf Paus et al Investigation Labs, Vol 71, No 1, p. 135, 1994).

[0010]FIG. 1 shows a scheme of the capsaicin-sensible sensory neuron and the localization of tackykinins (P substance and Neurokinin A) and CGRP with the receptors TRPV 1. The scheme would show the double function, afferent and efferent, of the sensorial fibers with the release of neuropeptides from the terminal like the P substance, Neurokinin A and CGRP (Calcitonin gene related peptides). Researches are progressing about the use of high dosages of Curcumin for the treatment of colon cancer, but it seems like any effect on the hair growth has been shown; Effect that instead has been obtained thanks to the administration of curcumin together with resveratrol.

[0011]Therefore, the object of the present invention is a pharmaceutical composition comprising resveratrol and/or the root of polygonum cuspidatum, containing resveratrol, and curcumin and/or root of the curcuma longa, containing curcumin, as active principles, in association with one or more adjuvant and/or excipients pharmacologically acceptable. The root of powdered polygonum cuspidatum, a plant commonly used in the traditional Chinese and Japanese medicine as circulatory tonic, is particularly rich in resveratrol. Epidemiological and in vitro studies suggest that its use reduces the incidence of cardiovascular diseases and cancers. The powdered root of Curcuma longa, a plant diffused in the oriental medicine, is very rich in active elements as curcuminoids, the elements responsible for the characteristic yellow color and probably for the anti-inflammatory, antiviral and detoxicant effects too.

[0012]According to the invention, the pharmaceutical composition can comprise also vitamin E and/or wheat germs containing vitamin E. In fact, the powdered wheat germs are one of the richest natural resources of vitamin E (or tocopherol) and are one of the most effective antioxidants against free radicals, the aggressive substances that proliferate in our body because of the action of pollution, inaccurate diets, sun or just age.

[0013]Moreover, according to the invention, the pharmaceutical composition can also comprise vitamin C and/or berries of Rosa canina containing vitamin C. In fact the powdered berry of Rosa canina is a natural source of C vitamin, important for the good functioning of the immune system and an excellent antioxidant too. The vitamin C fights any kind of infection and facilitates the repair of the connective tissue. The modern living conditions, the high level of air pollution, smoking and passive smoking, increase our need of vitamin C.

[0014]According to another embodiment of the present invention, the pharmaceutical composition can also comprise Capsaicin and/or the fruit of capsicum annum, which contains capsaicin. Capsicum annum, its powdered fruit in particular, is rich in important nutritional substances as flavonoids, vitamins (C, E, PP, and K), lecithins, mineral salts and capsaicin, an alkaloid responsible for its particular taste and for its activating properties. The extract of capsicum seems to be very effective in stimulating the vitality of the tissues and in activating the venous and capillary circulation.

[0015]In particular, in the composition according to this invention, the content of resveratrol can range from 3 to 6 mg; of Curcumin from 15 to 30 mg; of vitamin E from 50 to 100 mg; of vitamin C from 10 to 30 mg; of capsaicin from 2 to 5 mg; of powdered wheat germs from 50 to 450 mg, preferably from 100 to 350 mg; of powdered berries of Rosa canina from 50 to 450 mg, preferably from 100 to 350 mg; of the powdered fruit of capsicum annum from 50 to 450, preferably from 100 to 350 mg; of the powdered root of curcuma longa from 1 to 100 mg, preferably from 50 to 100 mg; of the powdered root of polygonum cuspidatum from 1 to 100 mg, preferably from 50 to 100 mg.

[0016]The abovementioned quantities are the quantities contained in one dosage unit.

[0017]According to a preferred embodiment of the invention, the composition comprises Rosa canina (titrated dried extract) 10%; natural vitamin C 150.00 mg.; synthetic vitamin C 15.00 mg; Curcuma (titrated dried extract) 95%; Curcumin 20.60 mg; synthetic Curcumin 20.00 mg; Poligonum cuspidatum (titrated dried extract) 98%; resveratrol 5.10 mg; synthetic resveratrol 5.00 mg.; wheat germ oil 60.00 mg.; Capsicum (titrated dried extract) 60% in capsaicin 5.00 mg.; synthetic capsaicin 3.00 mg.

[0018]The composition according to the invention can be presented in capsules, pills, solution and emulsion. If in capsules or pills, the suggested dosage is one or two units, before meals.

[0019]Further object of the present invention is the use of the composition for the cancer treatment, in particular the treatment of prostate carcinoma. Moreover, the composition according to the invention can be advantageously employed for the treatment of skin diseases, in particular of psoriasis, for the treatment and the prevention from ageing, for the treatment and the prophylaxis of diseases of the piliferous system, in particular of alopecia.

[0020]Another object of the present invention is a combination comprising resveratrol and curcumin for the simultaneous, separate or sequential use in the treatment of cancer, as for example, the prostate carcinoma, in the treatment of skin diseases as psoriasis and for the prevention and the treatment of alopecia.

[0021]It is understood that the abovementioned examples are just an exemplification offered to illustrate the practical usages of the invention. The invention in fact can vary in its dosages and in its components, adding other components similar to the one suggested, but without altering the conceptual basis of the invention.

[0022]The present invention will now be described by way of information, not restrictively, in its preferred ways of presentation, with a particular reference to the attached pictures, where:

[0023]FIG. 1 shows a scheme of the capsaicinoids-sensible sensory neuron, and the localization of tackykinins (substance P and Neurokinin A) and CGRP with the receptor TRPV 1.

EXAMPLE 1

Study on the Effect of Resveratrol and the Association of Resveratrol and Curcumin on the Prostate-Specific Antigen (PSA) in Patients Affected by Prostate Carcinoma, on Hair Growth and on Psoriasis.

[0024]A composition has been prepared. It contains RESVERATROL (poligonum cuspidatum) and other antioxidants and it is called "Resverage". Its ingredients are: Rosa canina (titrated dried extract) 10%; natural vitamin C 200.00 mg; synthetic vitamin C 20.00 mg; wheat germ oil 60.00 mg; poligonum cuspidatum (titrated dried extract) 98%; resveratrol 8.20 mg; synthetic resveratrol 8.00 mg. The administration capsules of this composition to 5 patients did not give any positive result. Thus, another composition containing resveratrol and curcumin (Curcuma longa) has been prepared and tested on a bigger group of patients.

[0025]In detail the composition was composed of: [0026]Rosa canina (titrated dried extract) 10%, natural vitamin C 150.00 mg., synthetic vitamin C 15.00; [0027]Curcuma (titrated dried extract) 95%, Curcumin 20.60; synthetic Curcumin 20.00 mg [0028]Poligonum cuspidatum (titrated dried extract) 98%; resveratrol 5.10 mg.; Synthetic resveratrol 5.00 mg [0029]Wheat germ oil 60.00 mg, capsicum (titrated dried extract) 60% in capsaicin 5.00 mg; synthetic capsaicin 3.00 mg. [0030]Ingredients: dicalcic phosphate, fruits of rosa canina (titrated dried extract) maltodextrins 10%; natural vitamin C, wheat germ oil plv titrated 40% (triticum vulgaris modified amylum, microcrystalline cellulose, Curcuma rhizome (titrated dried extract) Curcuma Longa L. maltodextrins 95%; Curcumin, anti-agglomerative, vegetal stearate magnesium; coating agents: hydroxyl-propyl-methyl cellulose, glycerol, titanium dioxide; Capsicum fruit (titrated dried extract) (capsicum frutescens, capsicum annum) 60% in capsaicin, Poligonum Cuspidatum root (dried extract) 98%, resveratrol.

[0031]In this testing, apart from a relevant anti-cancer action on hormone-insensible prostate neoplasia, an effect on some patients has also been the stop of the hair loss and the growth of hair, sometimes of the original color too. Therefore patients without any neoplastic disease, but affected by alopecia or hair loss, have been included to the testing.

[0032]Materials and Methods

[0033]The group treated only with resveratrol didn't show any relevant variation, except from two cases that showed a slight decrease.

[0034]Group treated with resveratrol: 5 patient, aged between 64 and 76 years old, affected by a hormone-independent prostate carcinoma have been treated with Resverage, 4 pills a day, for a period that ranged from 30 and 90 days. The basic PSA varied from 25/220 mg/ml and it has been monitored for the 15 days following the treatment period. The patients tolerated the therapy without showing any nuisance. Table n°1 shows the results obtained with the treatment with Resverage.

TABLE-US-00001 TABLE 1 Age Reason for Sex the treatment Dosage Duration Results 64 PROSTATE 4 CAPSULES NO VARIATION MAN CARCINOMA A DAY FOR ON PSA VALUE IN SITU 30 DAYS 70 PROSTATE 4 CAPSULES NO VARIATION MAN CARCINOMA A DAY FOR ON PSA VALUE 30 DAYS 72 PROSTATE 4 CAPSULES NO VARIATION MAN CARCINOMA A DAY FOR ON PSA VALUE 30 DAYS 75 PROSTATE NO VARIATION MAN CARCINOMA ON PSA VALUE 78 PROSTATE 4 CAPSULES SLIGTH MAN CARCINOMA A DAY FOR VARIATION ON 30 DAYS PSA VALUE

[0035]Group treated with curcumin e resveratrol: 20 patients, some of them affected by prostate neoplasia and/or by hair loss, treated with curcumin and resveratrol for a period ranging from 30 days to 6 months. The results are displayed on table n°2:

TABLE-US-00002 [0035]TABLE 2 Age Reason for Dosage Sex the treatment Duration Results 67 PROSTATE 4 CAPSULES/DAY REDUCTION OF PSA MAN CARCINOMA 2 CYCLES OF 60 VALUE. DAYS HAIR GROWTH IN BALD AREAS. 69 PROSTATE 4 CAPSULES/DAY REDUCTION OF PSA MAN CARCINOMA FOR 6 MONTHS VALUE. HAIR GROWTH OF THE ORIGINAL COLOUR IN BALD AREAS. 46 PROSTRATITIS 2 CAPSULES/DAY STOP OF HAIR LOSS, MAN FOR 6 MONTHS PSORIASIS DISAPPEARED. 71 PROSTATE 2 CAPSULES/DAY STOP OF HAIR LOSS, MAN CARCINOMA FOR 3 MONTHS PSORIASIS DISAPPEARED, REDUCTION OF PSA VALUE 54 HAIR LOSS 2 CAPSULES/DAY STOP OF HAIR LOSS MAN FOR 30 DAYS 64 PROSTRATITIS 6 CAPSULES/DAY STOP OF HAIR LOSS, MAN FOR 30 DAYS HAIR GROWTH, CLINIC CONDITIONS IMPROVEMENT, ANY VARIATION OF PSA VALUE 56 HAIR LOSS 1 CAPSULE/DAY STOP OF HAIR LOSS, MAN FOR 4 MONTHS HAIR GROWTH 32 HAIR LOSS 2 CAPSULES/DAY STOP OF HAIR LOSS, MAN FOR 2 MONTHS HAIR GROWTH 75 PROSTRATITIS 2 CAPSULES/DAY CLINIC CONDITIONS MAN FOR 3 MONTHS IMPROVEMENT, STOP OF HAIR LOSS, HAIR GROWTH 66 VOLOUNTEER 2 CAPSULES/DAY STOP OF HAIR LOSS, MAN FOR 4 MONTHS ORIGINAL COLOUR HAIR GROWTH 69 HAIR LOSS 2 CAPSULES/DAY HAIR GROWTH WOMAN FOR 4 MONTHS 39 HAIR LOSS 2 CAPSULES/DAY STOP OF HAIR LOSS, WOMAN 2 CYCLES OF 45 HAIR GROWTH DAYS 29 PROSTRATITIS 4 CAPSULES/DAY NOT VALUABLE MAN INTERRUPTION OF THE TREATMENT FOR INTOLERANCE 28 HAIR LOSS 2 CAPSULES/DAY NOT VALUABLE MAN FOR 10 DAYS INTERRUPTION OF THE TREATMENT FOR INTOLERANCE 64 HAIR LOSS 4 CAPSULES/DAY STOP OF HAIR LOSS, WOMAN FOR 2 MONTHS HAIR GROWTH 75 PROSTATE 2 CAPSULES/DAY REDUCTION OF PSA MAN CARCINOMA FOR 2 MONTHS VALUE, HAIR GROWTH 75 HAIR LOSS 2 CAPSULES/DAY STOP OF HAIR LOSS, WOMAN FOR 3 MONTHS HAIR GROWTH 80 PROSTATE 2 CAPSULES/DAY REDUCTION OF PSA MAN CARCINOMA AND FOR 4 MONTHS VALUE, INTOLERANCE TO ANY ACTION ON HAIR ANTI- ANDROGENICS 65 HAIR LOSS 2 CAPSULES/DAY STOP OF HAIR LOSS, WOMAN FOR 3 MONTHS HAIR GROWTH

[0036]We comment the most startling cases of table 2:

[0037]Case 2: 69 years old man operated of radical prostatectomy for carcinoma 10 years before starting the treatment with curcumin and resveratrol (Capsures). Anatomic-clinic stage at the moment of the intervention: T3; Gleason 5+4. During the period between the operation and our testing, the patient had had various treatments (total androgenic block, anti-androgens radiant therapy). Before the treatment with Capsures, the PSA value was at 3300 mg/ml, without answer to the traditional treatments. After the administration for 30 days of Capsures, 4 pills a day, the value of PSA decreased to 1500 and then to 700 after 60 days. Afterwards, the patient interrupted the treatment and his PSA value increased until the patient restarted the treatment with Capsures again.

[0038]Case 4: 71 years old man operated for a prostate and vesicle carcinoma 10 years before, with a PSA value at 62 mg/ml. The administration of a slight dose of antiandrogen for 5 days and then of Capsures of 4 pills a day let to a reduction in the level of PSA after 60 days to 7.4 and then to 6.80. The patient suffered also of psoriasis of the scalp, that disappeared after the treatment and that by now, after 8 months has not reappeared.

[0039]Case 6: 64 years old man affected by prostratitis that tried various treatments. After the treatment with Capsures, 6 capsules a day, after 30 days had no more perineal pain and had a hair growth.

[0040]Case 14: 75 years old man, operated 4 years before for radical prostatectomy, intolerant to hormonal treatment he has been treated with Capsures, 4 pills a day for 60 days. His PSA value reduced from 4.5 to 2.4.

[0041]In one case, the Capsures treatment caused an increase of PSA. He was a patient with spread metastasis but his clinic conditions improved.

[0042]As far as its action on hair is concerned, some patients, especially women that were considerably loosing their hair, after 20 days of treatment confirmed to have had a reduction in their hair loss. In bald patients, the hair, sometimes of the original color restarted to grow even after the ablation of the white hair.

CONSIDERATIONS AND CONCLUSIONS

[0043]The compound containing just resveratrol as active agent (Resverage) didn't cause a reduction of the PSA value and this can be due to the low bioavailability of the molecule. In the cases of prostate carcinoma the efficacy of the association of resveratrol with curcumin can be due to a higher concentration in the circulation and therefore in the tissues explained by the lipophilia of the active elements of curcumin.

[0044]The association of resveratrol and curcumin seems to have a synergic effect that enhances the anti-inflammatory power of the two active elements. It is an essential activity because in the prostate carcinoma there is a phlogistic action caused by hyperincretion of enzymes as the cyclooxygenase 1 and 2.

[0045]As far as the action on hair is concerned, it is unquestionably due to the administration of the two combined active elements, since in the compound with just resveratrol no result has been shown and in the many cases in India and in Europe where Curcumin has been employed, any effect on hair has never been reported. The most important aspect rarely highlighted is that curcuminoids are capsaicinoid substances.

[0046]It is demonstrated that hair has a sensory innervation defined capsaicin-sensitive, whose characteristic is that the C-amyelinated fibers have an afferent and efferent function (see scheme of picture n°1).

[0047]Those fibers, whose nerve cell is in the posterior roots, once stimulated release neuropeptides like the P substance, Neurokinin A and the Calcitonin Gene Related Peptide (CGRP). Experimental researches demonstrated that the desensibilization of those fibers leads to skin lesions localized in the cervical region of the rat. These experiments indicate the existence of a tropic function. It is probable that the loss of hair is a result of the deficit of neuropeptides released by the fibers that innervate the scalp.

[0048]Therefore it is possible that the administration of a substance that has as activity similar to capsaicin, as the Curcumin that metabolizes like an active curcumoid, can stimulate the sensorial fibers that have a tropic function, and that resveratrol has a vehicular function on the tissues. Therefore, the composition of the present invention is active on cases of hormone-insensible prostate carcinoma but in particular on hair, as our research has proven. The efficacy of the composition according to the present invention also depends on the great lyophilic properties of a capsaicinoid, curcumin on the anti-inflammatory effect of the two substances.

[0049]The interference of the hormonal action on hair loss is unquestionable, even if capsaicinoid-sensible sensory innervations are an ancestral phenomenon that does not depend on the hormonal mechanisms, but through a metabolic way different from the ordinary one. The growth and the pigmentation of the hair follicle seem to be controlled by epitelius-mesenchimoneuroechtodermmic interactions not very well known, but with an important role of the P substance on the hair growth in vivo.


Patents by YOUNG & THOMPSON

Edited by browser, 18 March 2010 - 02:35 AM.

[maxwatt]

Nutr Cancer. 2009;61(4):544-53.
Curcumin synergizes with resveratrol to inhibit colon cancer.
Majumdar AP, Banerjee S, Nautiyal J, Patel BB, Patel V, Du J, Yu Y, Elliott AA, Levi E, Sarkar FH.

John D. Dingell VA Medical Center, 4646 John R, Room B-4238, Detroit, MI 48201, USA. a.majumdar@wayne.edu
Development and progression of many malignancies, including colorectal cancer, are associated with activation of multiple signaling pathways. Therefore, inhibition of these signaling pathways with noncytotoxic natural products represents a logical preventive and/or therapeutic approach for colon cancer. Curcumin and resveratrol, both of which inhibit the growth of transformed cells and colon carcinogenesis, were selected to examine whether combining them would be an effective preventive and/or therapeutic strategy for colon cancer. Indeed, the combination of curcumin and resveratrol was found to be more effective in inhibiting growth of p53-positive (wt) and p53-negative colon cancer HCT-116 cells in vitro and in vivo in SCID xenografts of colon cancer HCT-116 (wt) cells than either agent alone. Analysis by Calcusyn software showed synergism between curcumin and resveratrol. The inhibition of tumors in response to curcumin and/or resveratrol was associated with the reduction in proliferation and stimulation of apoptosis accompanied by attenuation of NF-kappaB activity. In vitro studies have further demonstrated that the combinatorial treatment caused a greater inhibition of constitutive activation of EGFR and its family members as well as IGF-1R. Our current data suggest that the combination of curcumin and resveratrol could be an effective preventive/therapeutic strategy for colon cancer.

PMID: 19838927

There is increasing evidence that combinations of polyphenols are more effective than one alone against cancer, likely by targeting multiple pathways. But again, cancer is a catch-all term for many different disorders resulting in rapid or excessive cell growth. EGCG, genistein, capsicum are other's that have shown anti-neoplastic effects.

Edited by maxwatt, 19 March 2010 - 09:16 AM.
spellng

[bixbyte]

[0038]Case 4: 71 years old man operated for a prostate and vesicle carcinoma 10 years before, with a PSA value at 62 mg/ml. The administration of a slight dose of antiandrogen for 5 days and then of Capsures of 4 pills a day let to a reduction in the level of PSA after 60 days to 7.4 and then to 6.80. The patient suffered also of psoriasis of the scalp, that disappeared after the treatment and that by now, after 8 months has not reappeared.

The Resveratrol might have helped as Sinclair suggests.
But I would want to drop my PSA level down to 2.
As per my previous post, I suggest you ask your MD if he will dispense 1 milligram Propecia per day for 30 days.
Then have your PSA tested after 30 days.
If your PSA declines drastically, there is a good possibility that your cancer could be slowed down radically.
Plus if you can tolerate the minor side effects ask your MD to up the dose to 5 milligrams day?
Please, I am just trying to help you.

I am not an Oncologist or MD and this is my most humble opinion.
But, I studied this material.

[browser]

[0038]Case 4: 71 years old man operated for a prostate and vesicle carcinoma 10 years before, with a PSA value at 62 mg/ml. The administration of a slight dose of antiandrogen for 5 days and then of Capsures of 4 pills a day let to a reduction in the level of PSA after 60 days to 7.4 and then to 6.80. The patient suffered also of psoriasis of the scalp, that disappeared after the treatment and that by now, after 8 months has not reappeared.

The Resveratrol might have helped as Sinclair suggests.
But I would want to drop my PSA level down to 2.
As per my previous post, I suggest you ask your MD if he will dispense 1 milligram Propecia per day for 30 days.
Then have your PSA tested after 30 days.
If your PSA declines drastically, there is a good possibility that your cancer could be slowed down radically.
Plus if you can tolerate the minor side effects ask your MD to up the dose to 5 milligrams day?
Please, I am just trying to help you.

I am not an Oncologist or MD and this is my most humble opinion.
But, I studied this material.

I asked my doctor about Propecia. He said no and ordered more DIM into my bio-identical cream. Why are you so gung ho about Propecia? The abstract of the study you quoted said said that

These data suggest that the HER2/ERBB3 pathway is a critical target in hormone-refractory prostate cancer.

. I don't have hormone refractory PCa. I was on an herbal ADT like supplement for 3 months only last year while deciding what to do about my newly diagnosed PCa.

[bixbyte]

I asked my doctor about Propecia. He said no and ordered more DIM into my bio-identical cream. Why are you so gung ho about Propecia?

Why would your Doctor raise your Testosterone Levels with DIM Bio Identical Hormone Creams if you have Prostate Cancer?
Does not sound like a Doctor to me?
That would increase your PSA levels and increase the possibility that your PC might metastasize.
You told me your PSA test results were up?
Propecia in many males creates the opposite effect and reduce my PSA and lower my possibility of Cancer spread.

Good Luck with your Cancer.

[browser]

This is a somewhat surprising and very worrying development (given that my son is on resveratrol and docetaxel - a chemo drug related to pacitaxel):

Eur J Cancer. 2010 Mar 9.
Resveratrol attenuates the anticancer efficacy of paclitaxel in human breast cancer cells invitro and in vivo.

Fukui M, Yamabe N, Zhu BT.

Department of Pharmacology, Toxicology and Therapeutics, School of Medicine, University of Kansas Medical Center, Kansas City, KS 66160, USA.

It was reported recently that resveratrol could sensitise a number of cancer cell lines to the anticancer actions of several other cancer drugs, including paclitaxel. In the present study, we further investigated whether resveratrol could sensitise human breast cancer cells to paclitaxel-induced cell death. Unexpectedly, we found that resveratrol strongly diminished the susceptibility of MDA-MB-435s, MDA-MB-231 and SKBR-3 cells to paclitaxel-induced cell death in culture, although this effect was not observed in MCF-7 cells. Using MDA-MB-435s cells as a representative model, a similar observation was made in athymic nude mice. Mechanistically, the modulating effect of resveratrol was partially attributable to its inhibition of paclitaxel-induced G(2)/M cell cycle arrest, together with an accumulation of cells in the S-phase. In addition, resveratrol could suppress paclitaxel-induced accumulation of reactive oxygen species (ROS) and subsequently the inactivation of anti-apoptotic Bcl-2 family proteins. These observations suggest that the strategy of concomitant use of resveratrol with paclitaxel is detrimental in certain types of human cancers. Given the widespread use of resveratrol among cancer patients, this study calls for more preclinical and clinical testing of the potential benefits and harms of using resveratrol as a dietary adjuvant in cancer patients.

Comments, anyone?

In addition, resveratrol could suppress paclitaxel-induced accumulation of reactive oxygen species (ROS) and subsequently the inactivation of anti-apoptotic Bcl-2 family proteins.

This supposition tells me nothing about Resveratrol's effect on ROS produced by high dose IV Vitamin C, for which I'm paying a small fortune.

[ppp]

This is a somewhat surprising and very worrying development (given that my son is on resveratrol and docetaxel - a chemo drug related to pacitaxel):

Eur J Cancer. 2010 Mar 9.
Resveratrol attenuates the anticancer efficacy of paclitaxel in human breast cancer cells invitro and in vivo.

Fukui M, Yamabe N, Zhu BT.

Department of Pharmacology, Toxicology and Therapeutics, School of Medicine, University of Kansas Medical Center, Kansas City, KS 66160, USA.

It was reported recently that resveratrol could sensitise a number of cancer cell lines to the anticancer actions of several other cancer drugs, including paclitaxel. In the present study, we further investigated whether resveratrol could sensitise human breast cancer cells to paclitaxel-induced cell death. Unexpectedly, we found that resveratrol strongly diminished the susceptibility of MDA-MB-435s, MDA-MB-231 and SKBR-3 cells to paclitaxel-induced cell death in culture, although this effect was not observed in MCF-7 cells. Using MDA-MB-435s cells as a representative model, a similar observation was made in athymic nude mice. Mechanistically, the modulating effect of resveratrol was partially attributable to its inhibition of paclitaxel-induced G(2)/M cell cycle arrest, together with an accumulation of cells in the S-phase. In addition, resveratrol could suppress paclitaxel-induced accumulation of reactive oxygen species (ROS) and subsequently the inactivation of anti-apoptotic Bcl-2 family proteins. These observations suggest that the strategy of concomitant use of resveratrol with paclitaxel is detrimental in certain types of human cancers. Given the widespread use of resveratrol among cancer patients, this study calls for more preclinical and clinical testing of the potential benefits and harms of using resveratrol as a dietary adjuvant in cancer patients.

Comments, anyone?

And just to complicate matters even further...This has just arrived:

Oncol Rep. 2010 Jan;23(1):279-86.
Resveratrol down-regulates survivin and induces apoptosis in human multidrug-resistant SPC-A-1/CDDP cells.

Zhao W, Bao P, Qi H, You H.

Department of Respiratory Medicine, The Second Affiliated Hospital of Chinese PLA General Hospital, Beijing, P.R. China. zhaowg2008@qq.com

We studied the effect of resveratrol treatment on multidrug-resistant human non-small cell lung cancer cells. Human multidrug-resistant SPC-A-1/CDDP cells were treated with resveratrol at a concentration of 25, 50, or 100 microM in in vitro studies and nude mice were implanted with multidrug-resistant SPC-A-1/and fed a special diet that included resveratrol at a dose of either 1 g/kg/day or 3 g/kg/day in in vivo studies. No adverse toxicological effects of resveratrol treatment were observed. The rate of cell proliferation, apoptosis ratio, cell cycle phase distribution, IC50 values of cisplatin, gefitinib, and paclitaxel, implanted tumour volume, and expression of survivin in resveratrol-treated and control mice were then determined. Resveratrol significantly inhibited the proliferation of SPC-A-1/CDDP cells, induced apoptosis, arrested the cell cycle phase between G0-G1 and S phase or at the G2/M phase, decreased the IC50 values of multiple chemotherapeutic drugs, and showed anti-tumour effects in nude mice that had been implanted with SPC-A-1/CDDP cells. In additional, resveratrol affected the proliferation of SPC-A-1/CDDP cells in a dose- and time-dependent manner. Expression of survivin in SPC-A-1/CDDP cells decreased after they were treated with all concentrations of resveratrol and resveratrol was also found to have a dose-dependent effect on survivin expression. Resveratrol can induce apoptosis in multidrug-resistant human NSCLC SPC-A-1/CDDP cells by down-regulating the expression of survivin.

If anyone has access to the full paper I'd be really grateful for a pdf...

[niner]

And just to complicate matters even further...This has just arrived:

Oncol Rep. 2010 Jan;23(1):279-86.
Resveratrol down-regulates survivin and induces apoptosis in human multidrug-resistant SPC-A-1/CDDP cells.

Zhao W, Bao P, Qi H, You H.

Department of Respiratory Medicine, The Second Affiliated Hospital of Chinese PLA General Hospital, Beijing, P.R. China. zhaowg2008@qq.com

We studied the effect of resveratrol treatment on multidrug-resistant human non-small cell lung cancer cells. Human multidrug-resistant SPC-A-1/CDDP cells were treated with resveratrol at a concentration of 25, 50, or 100 microM in in vitro studies and nude mice were implanted with multidrug-resistant SPC-A-1/and fed a special diet that included resveratrol at a dose of either 1 g/kg/day or 3 g/kg/day in in vivo studies. No adverse toxicological effects of resveratrol treatment were observed. The rate of cell proliferation, apoptosis ratio, cell cycle phase distribution, IC50 values of cisplatin, gefitinib, and paclitaxel, implanted tumour volume, and expression of survivin in resveratrol-treated and control mice were then determined. Resveratrol significantly inhibited the proliferation of SPC-A-1/CDDP cells, induced apoptosis, arrested the cell cycle phase between G0-G1 and S phase or at the G2/M phase, decreased the IC50 values of multiple chemotherapeutic drugs, and showed anti-tumour effects in nude mice that had been implanted with SPC-A-1/CDDP cells. In additional, resveratrol affected the proliferation of SPC-A-1/CDDP cells in a dose- and time-dependent manner. Expression of survivin in SPC-A-1/CDDP cells decreased after they were treated with all concentrations of resveratrol and resveratrol was also found to have a dose-dependent effect on survivin expression. Resveratrol can induce apoptosis in multidrug-resistant human NSCLC SPC-A-1/CDDP cells by down-regulating the expression of survivin.

The IC50 value of a drug is the concentration of the drug that inhibits 50% of the activity in question. Assuming that the activity in question is the growth or survival of these tumor cells, a reduction of the IC50 value of a chemotherapeutic agent is a good thing, not a bad thing. It means the drug is more potent. Do note that they used quite enormous doses of resveratrol here.

[ppp]

And just to complicate matters even further...This has just arrived:

Oncol Rep. 2010 Jan;23(1):279-86.
Resveratrol down-regulates survivin and induces apoptosis in human multidrug-resistant SPC-A-1/CDDP cells.

Zhao W, Bao P, Qi H, You H.

Department of Respiratory Medicine, The Second Affiliated Hospital of Chinese PLA General Hospital, Beijing, P.R. China. zhaowg2008@qq.com

We studied the effect of resveratrol treatment on multidrug-resistant human non-small cell lung cancer cells. Human multidrug-resistant SPC-A-1/CDDP cells were treated with resveratrol at a concentration of 25, 50, or 100 microM in in vitro studies and nude mice were implanted with multidrug-resistant SPC-A-1/and fed a special diet that included resveratrol at a dose of either 1 g/kg/day or 3 g/kg/day in in vivo studies. No adverse toxicological effects of resveratrol treatment were observed. The rate of cell proliferation, apoptosis ratio, cell cycle phase distribution, IC50 values of cisplatin, gefitinib, and paclitaxel, implanted tumour volume, and expression of survivin in resveratrol-treated and control mice were then determined. Resveratrol significantly inhibited the proliferation of SPC-A-1/CDDP cells, induced apoptosis, arrested the cell cycle phase between G0-G1 and S phase or at the G2/M phase, decreased the IC50 values of multiple chemotherapeutic drugs, and showed anti-tumour effects in nude mice that had been implanted with SPC-A-1/CDDP cells. In additional, resveratrol affected the proliferation of SPC-A-1/CDDP cells in a dose- and time-dependent manner. Expression of survivin in SPC-A-1/CDDP cells decreased after they were treated with all concentrations of resveratrol and resveratrol was also found to have a dose-dependent effect on survivin expression. Resveratrol can induce apoptosis in multidrug-resistant human NSCLC SPC-A-1/CDDP cells by down-regulating the expression of survivin.

The IC50 value of a drug is the concentration of the drug that inhibits 50% of the activity in question. Assuming that the activity in question is the growth or survival of these tumor cells, a reduction of the IC50 value of a chemotherapeutic agent is a good thing, not a bad thing. It means the drug is more potent. Do note that they used quite enormous doses of resveratrol here.

That's why I said that it complicates things further - it's a result in the opposite direction to the previous one.

[browser]

This is a somewhat surprising and very worrying development (given that my son is on resveratrol and docetaxel - a chemo drug related to pacitaxel):

Eur J Cancer. 2010 Mar 9.
Resveratrol attenuates the anticancer efficacy of paclitaxel in human breast cancer cells invitro and in vivo.

Fukui M, Yamabe N, Zhu BT.

Department of Pharmacology, Toxicology and Therapeutics, School of Medicine, University of Kansas Medical Center, Kansas City, KS 66160, USA.

It was reported recently that resveratrol could sensitise a number of cancer cell lines to the anticancer actions of several other cancer drugs, including paclitaxel. In the present study, we further investigated whether resveratrol could sensitise human breast cancer cells to paclitaxel-induced cell death. Unexpectedly, we found that resveratrol strongly diminished the susceptibility of MDA-MB-435s, MDA-MB-231 and SKBR-3 cells to paclitaxel-induced cell death in culture, although this effect was not observed in MCF-7 cells. Using MDA-MB-435s cells as a representative model, a similar observation was made in athymic nude mice. Mechanistically, the modulating effect of resveratrol was partially attributable to its inhibition of paclitaxel-induced G(2)/M cell cycle arrest, together with an accumulation of cells in the S-phase. In addition, resveratrol could suppress paclitaxel-induced accumulation of reactive oxygen species (ROS) and subsequently the inactivation of anti-apoptotic Bcl-2 family proteins. These observations suggest that the strategy of concomitant use of resveratrol with paclitaxel is detrimental in certain types of human cancers. Given the widespread use of resveratrol among cancer patients, this study calls for more preclinical and clinical testing of the potential benefits and harms of using resveratrol as a dietary adjuvant in cancer patients.

Comments, anyone?

I have prostate cancer. I'm getting Vitamin C IVs to stimulate my immune system and also create ROS to kill cancer cells. I'm also taking at least 3 grams of Resveratrol a day in the form of Nitro 250 plus buccal Resveratrol powder. Bill Sardi of Longev* started me off on Resveratrol. Bill told me the mechanism by which Resveratrol at higher doses would kill cancer is oxidation, i.e. ROS. The literature shows Bill's statement was wrong. Bill told me to take 10 grams of fish oil daily to aid in the oxidation and that the IVC would help in the oxidation. Well, it looks as though Resveratrol is actually preventing the IVC from killing cancer cells with ROS. Dr. Snuffy Myers, the prostate cancer survivor and expert prostate cancer prostate cancer oncologist tells his patients to take 500-1000 mg. each of Resveratrol and Quercetin in the form of Nitro 250 and MCT Quercetin but that prostate cancer patients should only take Resveratrol while under the care of a physician who knows all the medical implications of Resveratrol. This is better said than done since use of Resveratrol is very new and scarcely researched.

Thanks for the very helpful post. More things to ponder.

The thing about Quercetin is that it's a very strong inducer of Nrf2 - which drives the anti-oxidant response that protects the cell from oxidative damage...

Which is why, despite my math mistake where the IC50 inhibition in the liver of Resveratrol by quercetin is in the picoMole range and the IC50 for salicilic acid is in the micro Mole range, I'm going to avoid the Quercetin and take a few adult sized aspirins before I take myResveratrol.