This was discussed last time around and has been an ongoing discussion over the last couple of years. The heart of the matter is cost. Will it cost too much to put the fat soluble nutrients into softgels, when most of us know to take multi's with fat. Has the cost of including a lipid carrier gone down? Please discuss.
Softgels, powder, fat soluble nutrients, discussion
#1
Posted 05 February 2012 - 03:02 PM
This was discussed last time around and has been an ongoing discussion over the last couple of years. The heart of the matter is cost. Will it cost too much to put the fat soluble nutrients into softgels, when most of us know to take multi's with fat. Has the cost of including a lipid carrier gone down? Please discuss.
#2
Posted 05 February 2012 - 03:44 PM
#3
Posted 05 February 2012 - 05:25 PM
There is, however, another possibility: Licaps are capable of holding lipid solutions, and they are assembled like an ordinary hard gelcap, then sealed in some way (probably heat-sealed). Because of these characteristics, I speculate that they might have lower minimums, and might be a possibility. I don't actually know the numbers though, so we'd need to check that out.
As far as I know softgels have a shelf life that is as good as, or perhaps better than capsules.
#4
Posted 05 February 2012 - 05:26 PM
From my experience, for example, I need double the amount of D3 in dry capsules than in oil to reach the same 25(OH)D serum level - even taken with the fattiest meal. So that's not economical either. But to place all the water-soluble nutrients in softgels too, would be a waste.The heart of the matter is cost. Will it cost too much to put the fat soluble nutrients into softgels, when most of us know to take multi's with fat.
#5
Posted 06 February 2012 - 02:22 AM
#6
Posted 09 February 2012 - 05:42 AM
Licaps are ok, but they have a fair amount of limitations. They aren't heat sealed, they sort of get a little bit of liquid applied to the capsule where the cap and body meet and capillary action wicks it in and sort of welds it together. But there are a fair number of leakers that have to get inspected out after putting them on trays in a vacuum chamber which makes the leakers apparent. But Licaps don't have to be dried like softgels so they can be made in smaller quantity. I believe they do tend to be a bit more expensive than softgels (ignoring the minimum quantity thing). I haven't costed any in a long time though.
#7
Posted 09 February 2012 - 09:19 PM
#8
Posted 13 February 2012 - 05:25 AM
#9
Posted 27 February 2012 - 03:21 AM
#11
Posted 29 February 2012 - 10:52 PM
Licaps already have quite a bit of MCT in it, so we can't put in too much.. maybe 400mg per 00 capsule, more when using a 000 capsule.
Minimum: Minimum is 100,000 capsules (however they did make it 300,000 at one point in time, then went down to 100k again.)
Cost. Compared to MRSpud, they appear to be 2-4 times more expensive per 1000 than softgels, but I would ask MrSpud to check price per softgel capsule size, and I will compare them better, when I know capsule size pricing of softgel.
I hope this helps.
A
Edited by Anthony_Loera, 29 February 2012 - 11:03 PM.
#12
Posted 29 February 2012 - 11:06 PM
I will say that using licaps or a softgel will increase the number of capsules one takes, which might make this a deterrent to taking capsules. The biggest complaint (other than price) I had from members and non-members here was... "why 6 capsules a day?"...
So, just keep that in mind...k ?
A
Edited by Anthony_Loera, 29 February 2012 - 11:08 PM.
#13
Posted 03 March 2012 - 04:29 PM
Back to the topic, a soft gel for the oils and oil soluble nutrients would be an excellent dosage form and delivery system. The blend would be kept under nitrogen during processing and encapsulation and this would keep them stable. Then a hard shell for the powders, even better a separate hard shell for the minerals than the other water soluble vitamins, and the use of coated vitamins for the ones that degrade easily and/or interact would be the ultimate. But now you would have 1 soft gel plus 2 hard shells and you would either have to sell them in separate bottles or put them in packets (3 different capsules in a cellophane type pouch) and it would be more expensive. It would be the best delivery system and would be the most stable this way though. You must make a compromise somewhere if you want to make 1 uniform blend of everything in one dosage form. I'm saying this because hygroscopic ingredients tend to pull moisture into the product and hydrolysis occurs and trace metals and or the minerals themselves catalyze the reactions that occur btw the actives leading to stability problems. For example, b vitamins and antioxidants like grapeseed extract can wick in moisture from the air or from the capsule shell, then the moisture makes the vitamin c degrade into furfural which is sped up if copper is present. You end up with a bunch of dark spots that look like mold but actually are usually furfural derivatives. There are other similar interactions going on all the time.
I don't know if this information helps you decide though.
#14
Posted 03 March 2012 - 05:00 PM
I've seen these interactions happen with tablets, hard shells and soft gels.
#16
Posted 03 March 2012 - 06:11 PM
Also tagged with one or more of these keywords: dry caps, powder, softgels, fat soluble nutrients
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