Health

Tracking A Biomarker Of Neurodegeneration (22-Test Analysis)

Sun, 12 Apr 2026 17:18:51 +0000

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Does Insulin Sensitivity Cause Hashimotos & is this reversable?

Fri, 10 Apr 2026 19:44:52 +0000

Hi,

So I did a few blood tests recently and the findings were:

Abnormal / Key Findings

High fasting insulin: 13.5 mIU/L
High fasting insulin resistance index (HOMA-IR): 2.2
High Thyroid Peroxidase Antibodies (TPOAb)
High Thyroglobulin Antibodies (TgAb)
Low SHBG
Slightly elevated CRP
Slightly elevated afternoon cortisol
Low Vitamin D

Relevant Symptoms / Correlated Issues

Brain fog
Fatigue / low energy
Hair thinning / dry skin
Skin issues (psoriasis-type)
Light sensitivity
Difficulty losing fat
Bloating
Depression, anxiety.

What I wanted to know is what changes would you recommend I make, is this hashimotos? Or are the anti-bodies reversable through diet?

Normal / Reassuring Results

Fasting glucose: 4.1 mmol/L
TSH
Free T4
Free T3
Testosterone
Prolactin
Oestradiol
Ferritin
Full Blood Count
Calprotectin (low = no gut inflammation)

Is Running Overrated?

Thu, 09 Apr 2026 02:19:51 +0000

Running has sharply diminishing returns — about 30 minutes a week captures most of the longevity benefit. Beyond that, you’re not gaining much.
Walking is the standout: 12,000 steps/day is associated with a ~75% reduction in all-cause mortality. Running 10,000 steps doesn’t come close to walking 10,000 steps.
There’s four-pillars of exercise for longevity: aerobic, HIIT, strength training, walking. Total required time: about 60–90 minutes/week for the structured exercise.
Sleep’s longevity data is weaker than most people assume — it didn’t make the top tier of habits when ranked by mortality reduction.
Biological age clocks are evolving fast (PhenoAge → BortzAge), but I don’t find them useful for choosing habits compared with all-cause mortality studies.

https://www.unaging.com/videos/is-running-overrated/

Infammation theory of depression and implications for treatment

Sat, 04 Apr 2026 09:01:43 +0000

Hi All,

One of the better known theories of depression is the idea that there is a chronic, low-grade (low intensity) inflammatory process in the brain. The time it takes to gradually resolve or ameliorate this inflammation may be the reason why so many drugs (and other substances) take a relatively long time (often 4 weeks or more) to produce substantial results.

This may have important implication for the treatment of depression. The hypothesis that logically follows, is that anti-inflammatory substances, as long as they cross the brain-blood-barrier, can ameliorate, if not eliminate, the inflammation, thus treating the depression.

The question, therefore, is what substances (herbs, vitamins, drugs, etc.) have the strongest anti-inflammatory action?

What substances have you taken that mitigated your depression, but took 1 week or longer to do so?

Allopregnanolone source

Sun, 29 Mar 2026 20:17:44 +0000

Hi, I need a source for allopregnenolone. It is for late alzheimer's/dementia. Pregnenolone was good as an anxiolytic. Hoping this can help with paranoia, anxiety, and irritability, along with being neuro supportive.

Please reply or message me with any sources. Willing to purchase from someone that has some, it is a desperate situation.

Thank you !

Ryan