10 replies to this topic

[kurdishfella]

I was sleepy but instead of sleeping I went to the gym becuase it was like 10am anyway so might aswell be awake the whole day too. But I noticed I felt more happy and confident and less anxiety when I went out . What happens why did I feel less social anxiety? Does cortisol reduce when you dont go to sleep or something?

[Galaxyshock]

Two things came to mind immediately

 

- Sleep deprivation increases PDE-4 leading to impaired cAMP levels and synaptic plasticity

- Increased adenosinergic signaling

 

Adenosine is an inhibitory neurotransmitter so perhaps that calmed you down.

[kurdishfella]

What about cortisol? isnt cortisol high in the morning then keep on reducing until you go to sleep? Also why did I feel more happy? I read dopamine increases somewhere when you dont go to sleep or something.

Edited by farshad, 11 March 2018 - 12:29 PM.

[ta5]

Maybe this will give you some ideas:

https://mosaicscienc...eat-depression/

[justmodz]

sleep deprivation is supposed to reduce cognitive impairment but for me all it means is that I am even worse at typing and my spelling is shot to pieces.  I does mean though that my ability to deal with people who are fools or who piss me off or who doubt my abilities is almost non existent and I am given to verbally reducing them into small pieces whereas normally I would tend to be polite (while wishing them on another planet) .   Other brain function is fine in fact I feel that when mildly sleep deprived I am better at working on abstracts.   What is sleep deprivation for one person is not for another as people need different amounts of sleep - for instance the elderly.  For people with depression sleep deprivation can be a winner https://mosaicscienc...eat-depression/

 

 

[Nate-2004]

You're very concerned about cortisol. This hormone is popularized as the stress hormone but really it's just the flip side of melatonin. Cortisol has about 3 different peaks during the day, starting with the largest one at around 8am and another smaller one around noon. Cortisol increases with light exposure just as melatonin increases in the absence of light, specifically in the blue/green spectrum.

 

Some cortisol is good, too much is bad, same goes for melatonin and well, just about everything.

 

If you're following good sleep hygiene guidelines (see the section on sleep here) and getting plenty of exercise, your cortisone levels should be optimal. I would start there before spending any money on anything. This is free.

 

Sleep deprivation can result in brain atrophy and symptoms quite similar to heavy alcohol intoxication. Trump is a good example of someone who is so obviously sleep deprived. Other examples are most lawyers. Do not let anyone or anything take priority over your sleep, or exercise for that matter. Make room for getting these things in order and you will be all good.

[kurdishfella]

You're very concerned about cortisol. This hormone is popularized as the stress hormone but really it's just the flip side of melatonin. Cortisol has about 3 different peaks during the day, starting with the largest one at around 8am and another smaller one around noon. Cortisol increases with light exposure just as melatonin increases in the absence of light, specifically in the blue/green spectrum.

 

Some cortisol is good, too much is bad, same goes for melatonin and well, just about everything.

 

If you're following good sleep hygiene guidelines (see the section on sleep here) and getting plenty of exercise, your cortisone levels should be optimal. I would start there before spending any money on anything. This is free.

 

Sleep deprivation can result in brain atrophy and symptoms quite similar to heavy alcohol intoxication. Trump is a good example of someone who is so obviously sleep deprived. Other examples are most lawyers. Do not let anyone or anything take priority over your sleep, or exercise for that matter. Make room for getting these things in order and you will be all good.

do you know any drugs that block CRF1 that you can get from doctor?

Edited by farshad, 13 March 2018 - 07:49 PM.

[Nate-2004]

Supposedly drug discovery and development for CRF1 antagonists is underway for the treatment of generalized anxiety disorders but for now, there's nothing that passes through the blood brain barrier, making anything that might do it in vitro pretty much useless.

 

Given what you're aiming for, I would seriously, highly recommend starting with that guide I linked, there are many lifestyle adjustments around sleep, exercise and nutrition you can make that will help considerably. Also try doing things that scare you, get on stage, perform, do sketch or stand-up or improv, and if you're on the younger end, pick up an extreme sport of some kind.

Edited by Nate-2004, 14 March 2018 - 12:44 PM.

[justmodz]

Supposedly drug discovery and development for CRF1 antagonists is underway for the treatment of generalized anxiety disorders but for now, there's nothing that passes through the blood brain barrier, making anything that might do it in vitro pretty much useless.

 

Given what you're aiming for, I would seriously, highly recommend starting with that guide I linked, there are many lifestyle adjustments around sleep, exercise and nutrition you can make that will help considerably. Also try doing things that scare you, get on stage, perform, do sketch or stand-up or improv, and if you're on the younger end, pick up an extreme sport of some kind.

go to New Zealand the land of extreme sports then you can find out what you want to do.  

[justmodz]

had eight of hours of sleep last night - usually it is four to five hours  - and I feel like I have a hangover and I am shaking.  I have decided that eight hours of sleep are not for me I need far less to function as I am never like this and the non melike feeling is causing stress as i hate feeling like crap.  Totally an advocate of less sleep.  I guess we all need differing amounts of sleep and mine is not eight hours

[CWF1986]

had eight of hours of sleep last night - usually it is four to five hours  - and I feel like I have a hangover and I am shaking.  I have decided that eight hours of sleep are not for me I need far less to function as I am never like this and the non melike feeling is causing stress as i hate feeling like crap.  Totally an advocate of less sleep.  I guess we all need differing amounts of sleep and mine is not eight hours

 

I knew a woman like this too.  She only needed 4 hours of sleep a night.  I'm one of those that does best with 9.  And lack of sleep hits me harder than most.  I can't go more than a couple weeks of 6 or fewer hours a night or I just start falling apart.  

 

A little tangential, but there is a rare genetic prion disease of the brain called fatal familial insomnia.  From the first symptoms, the survival time is only about a year and a half.  

 

From the Wiki Page: https://en.wikipedia...milial_insomnia

 

 

 As the disease progresses, the patient will become stuck in a state of pre-sleep limbo, or hypnagogia, which is the state just before sleep in healthy individuals.

 

It sounds like one the worst ways to go.  Not something I'd wish on my worst enemies.