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Crispr & Mitochondrial aging

tfam (transcription factor a mitochondrial) crispr & mitochondrial aging

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#1 dalack

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Posted 14 March 2018 - 08:41 PM


It seems that the technology for reversing mitochondrial aging without NAD+ has already been developed by Church's team. 

How long will it be before someone with the inexpensive equipment and knowledge try this on themselves?

I can see Crispr being the game changer that will solve aging in the near future.

 

 

 

https://www.nextbigf...st-comments-362


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#2 Nate-2004

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Posted 14 March 2018 - 09:58 PM

Thanks for the hope.

 

Looks promising. I really do plan on being a big participant in all this, I may even start saving up money now in order to get in with some of the first adopters.


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#3 sthira

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Posted 14 March 2018 - 11:29 PM

The interview is already more than a year old, so maybe we're down to T-Minus Nine Years Before Liftoff. I love George Church's optimism; if you wanna get up when you're down, I highly recommend Church's YouTube presentations. He's bright and playful, he seems to be having fun, and he's talking about genetically altering our species so we can eventually withstand the radiation and anti-gravity effects of indefinite space travel. Fucking bad ass.

Incidentally, Church's interlocutor in the above link is Greg Fahy. Fahy is also optimistic and plain-speaking -- recall that his lab is currently conducting the second cohort of thymus regeneration efforts. They're working hard with practically no funding in efforts to regrow the thymus for all of us -- which may help with aging reversal, or not -- your crystal ball is as clear as mine.

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#4 Turnbuckle

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Posted 15 March 2018 - 01:49 PM

The interview is already more than a year old, so maybe we're down to T-Minus Nine Years Before Liftoff. 

 

 

With something ten years in the future, it tends to stay ten years in the future.


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#5 dalack

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Posted 15 March 2018 - 02:35 PM

I think church is talking about 10 years for it to be fda approved.
He's already stated in another article that he has dozens of patents in the works to combat aging and he thinks he should be able to solve aging within 3-5 years with current tech.
If there's anyone that can solve it I think it's this genius.
Once he disloses his technology to enter clinical trials this will open up an path for self experimenters.

#6 QuestforLife

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Posted 15 March 2018 - 04:31 PM

George Church is surprising in that he has such an optimistic timeline, even by the standards of Aubrey de Grey and Ray Kurzweil, etc. I believe he has mentioned a trial in dogs first; but he's never elaborated on what that treatment would be, other than it being a gene therapy. I suspect he means that they'll have made real progress in defeating aging in 3-5 years, in the same way that Ray Kurzweil discusses various 'bridges' that allow us to live long enough to benefit from the next advance. Personally I expect some real progress within that time frame, but not a complete solution.



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#7 sthira

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Posted 15 March 2018 - 05:41 PM

We may contribute to acceleration of Church's efforts by signing up for his Harvard Personal Genome Project -- your genetic and other trait info would be then publicly available, though, which currently still feels freaky.

https://my.pgp-hms.org/signup

Freakiness won't last as privacy further degenerates. Just curious, what would be your privacy concerns about allowing any scientist to access to your publicly available whole sequenced genome?

Church doesn't sugarcoat the risks. He makes sure you are at least superficially aware of some shit. He's also formed another company, which I believe may offer to pay you if your generic contributions are accessed, and this model seems fair.

I'm more optimistic about Church's efforts than SENS; SENS has been long-talking beardedly for nearly two decades now, and in order to find out their progress we're still encouraged to read organizational reports.

to evaluate what the SENS foundation has done it may be more useful to go by their organizational reports


Senescent cell clearance by their spinoff companies seems promising, but does it also seem dwarfed by what Church appears to be envisioning?
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#8 Nate-2004

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Posted 15 March 2018 - 10:22 PM

What's so private about my genes? I mean, who cares? I find the betterment of health for all is far more important than some notion of privacy about genes. It's not like I'm sharing nude photos... or am I?


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#9 ceridwen

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Posted 15 March 2018 - 10:41 PM

Unfortunately they don't accept Brits

#10 sthira

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Posted 15 March 2018 - 11:11 PM

Unfortunately they don't accept Brits


I don't see why they wouldn't. If I were you (and battling stages of pre-dementia) I would reach out, begin a dialog, and see if they'll admit you: email jkaberry@hsph.harvard.edu.
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#11 Nate-2004

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Posted 15 March 2018 - 11:30 PM

There is a typo in the explanation about what DNA is, they said one of the four base pairs is adenosine, that's the neurotransmitter that caffeine mimics to block receptors, adenine is one of the four base pairs...



#12 sthira

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Posted 15 March 2018 - 11:51 PM

What's so private about my genes? I mean, who cares? I find the betterment of health for all is far more important than some notion of privacy about genes. It's not like I'm sharing nude photos... or am I?


I tend to agree. Have you signed up? It's $1,000.00 for your complete sequencing, and then they make it public, anyone can see you, click, and geneticists may use your sequence to study aging interventions. I'm still on the fence. One hesitation is that our personal data -- such as it is -- is far more valuable to us than, say, our credit scores. An open discussion of the pros and cons here would be helpful.

#13 Nate-2004

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Posted 16 March 2018 - 12:13 AM

I signed up btw.


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#14 sthira

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Posted 16 March 2018 - 12:28 AM

I signed up btw.


Sweet! What influenced your decision?
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#15 ceridwen

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Posted 16 March 2018 - 02:21 AM

@sthira I think the reason they don't accept Brits is because they want patients to commit themselves to taking part in the trial with weekly tests that go on each week. I probably wouldn't be able to stay for the length of time required anyway but did write to the email address you suggest just to see if they have anything on the back burner there that I could take advantage of.Many thanks

#16 ceridwen

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Posted 16 March 2018 - 02:25 AM

It would be wonderful to get paid for one's genetics. The money could be put towards other treatments in future perhaps?

#17 Nate-2004

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Posted 16 March 2018 - 12:19 PM

 

I signed up btw.


Sweet! What influenced your decision?

 

 

Mostly a desire to get things moving on the anti-aging front. The so called "privacy risks" seem more emotional, overly paranoid and silly than anything real or tangible, especially compared to the benefits to the whole world. You'd be more productive worrying about being struck by lightning during a shark attack than worrying about this. I don't know if I can afford $1000 right now but maybe soon.


Edited by Nate-2004, 16 March 2018 - 12:21 PM.


#18 sthira

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Posted 16 March 2018 - 02:23 PM

...I don't know if I can afford $1000 right now but maybe soon.


You said you signed up, apparently I misunderstood, and you didn't sign up. Unfortunately you can't currently get your entire genome sequenced yet from Church's project for less than $1,000. Eventually full sequencing will be less expensive. Note that when the project began in 2005, fewer than 20 people in the world had been sequenced, and the cost to sequence a new human genome was over $350,000.

I have nothing to do with this project yet -- still deciding -- and view it as a humanitarian effort. Concerns about privacy are real, though, and should not to be breezily dismissed. No one knows the future, and how your most personal, intimate data shall be used -- if at all -- in the future. It's a bit of a leap of faith.

This should probably be its own thread. Read more details about the project here:

https://pgp.med.harv...du/participate/

"The Harvard Personal Genome Project (PGP) provides an opportunity for individuals to help drive biological research. Each of us has different traits, genetics and environmental exposures – even identical twins.  The PGP uses an unconventional Open Science approach to provide a platform that allows scientific researchers to make connections between diseases, traits, environmental exposures and genetics. Through participation in the PGP, individuals publish data about themselves that can then be analyzed by researchers anywhere on the planet to understand human biology..."

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#19 Nate-2004

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Posted 16 March 2018 - 03:32 PM

I signed up and answered all the questions but they haven't reviewed it yet or asked to collect samples. I don't see anywhere on the site that I have to pay $1000 for a full sequencing. I guess they need me to do that myself with someone else? 






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